Community-acquired Pneumonia and Hospital-acquired Pneumonia

Lanks, Charles; Musani, Ali I.; Hsia, David

doi:10.1016/j.mcna.2018.12.008

Cited by 197 publications

(193 citation statements)

References 58 publications

Supporting

Mentioning

147

Contrasting

Unclassified

Order By: Relevance

“…Globally, pneumonia is one of the leading causes of morbidity and mortality and accounted for 3 million deaths worldwide in 2016 [1], and imparts an enormous financial burden to the medical system [2]. The coronavirus disease 2019 (COVID- 19) pneumonia has been declared a pandemic by the World Health Organization (WHO) on March 11, 2020 [3].…”

Section: Introductionmentioning

confidence: 99%

Network pharmacology to dissect the mechanisms of Yinlai Decoction for pneumonia

Bai

Huang

et al. 2020

BMC Complement Med Ther

View full text Add to dashboard Cite

Background: Pneumonia is a common respiratory disorder, which brings an enormous financial burden to the medical system. However, the current treatment options for pneumonia are limited because of drug resistance and side effects. Our previous study preliminarily confirmed that Yinlai Decoction (YD), a common prescription for pneumonia in clinical practice, can regulate the expression of inflammatory factors, but the mechanisms are unknown yet. Methods: In our work, a method named network pharmacology was applied, which investigated the underlying mechanisms of herbs based on a variety of databases. We obtained bioactive ingredients of YD on TCMSP database and collected potential targets of these ingredients by target fishing. Then the pneumonia-related targets database was built by TTD, Drugbank, HPO, OMIM, and CTD. Based on the matching targets between YD and pneumonia, the PPI network was built by STRING to analyze the interactions among these targets and then input into Cytoscape for further topological analysis. DAVID and KEGG were utilized for GO and pathway enrichment analysis. Then rat model based on LPS stimulated pneumonia was used to verify the possible mechanism of YD in treating pneumonia. Results: Sixty-eight active ingredients, 103 potential targets and 8 related pathways, which likely exert a number of effects, were identified. Three networks were constructed using Cytoscape, which were herb-component-network, YD-pneumonia target network, and herb-component-YD target-pneumonia network. YD was verified to treat LPSinduced pneumonia by regulating the inflammatory factor IL-6, which was a predicted target. Conclusion: Network analysis indicated that YD could alleviate the symptoms and signs of pneumonia through regulating host immune inflammatory response, angiogenesis and vascular permeability, the barrier function of the airway epithelial cells, hormone releasing and cell growth, proliferation, and apoptosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Network pharmacology to dissect the mechanisms of Yinlai Decoction for pneumonia

Bai

Huang

et al. 2020

BMC Complement Med Ther

View full text Add to dashboard Cite

show abstract

“…Pneumonia is a group of viral or bacterial infectioninduced lung disorders that can cause the symptoms of fever, cough, shortness of breath and fatigue [1][2][3]. There are various types of pneumonia, such as idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), idiopathic interstitial pneumonia (IIP) [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Association between FCGR2A rs1801274 and MUC5B rs35705950 variations and pneumonia susceptibility

Shi

et al. 2020

BMC Med Genet

View full text Add to dashboard Cite

Background: Herein, we collected currently published data to comprehensively evaluate the impact of the FCGR2A (Fc fragment of IgG receptor IIa) rs1801274 and MUC5B (mucin 5B, oligomeric mucus/gel-forming) rs35705950 variations on susceptibility to pneumonia diseases. Methods: We retrieved case-control studies from three online databases and applied the statistical approach of meta-analysis for a series of pooling analyses. Results: A total of fourteen case-control studies were included for FCGR2A rs1801274; while thirty-one case-control studies were included for MUC5B rs35705950. No significant difference between pneumonia cases and controls for FCGR2A rs1801274 was found. However, MUC5B rs35705950 was significantly associated with pneumonia susceptibility in the whole population under the genetic models of allelic T vs. G [OR (odds ratio) =3.78], carrier T vs. G (OR = 3.31), TT vs. GG (OR = 13.66), GT vs. GG (OR = 4.78), GT + TT vs. GG (OR = 5.05), and TT vs. GG + GT (OR = 6.47) (all P < 0.001, Bonferroni-adjusted P < 0.006; false discovery rate-adjusted P < 0.0010). Furthermore, we observed a similar positive result for subgroup analyses of "Caucasian", "Asian", "population-based control", and "idiopathic pulmonary fibrosis". Conclusions: MUC5B rs35705950, but not FCGR2A rs1801274, increases susceptibility to clinical pneumonia, especially to idiopathic pulmonary fibrosis, in both the Caucasian and Asian populations.

show abstract

“…Bacteria population in the lung microbiota, its impact in the number of variable species and composition, depends on the ability of bacteria to migrate from nose and mouth via the mucociliary clearance mechanisms and the local immunity, so depending on both the external room microenvironment with its sepsis and one's own competent immunity. Many bacteria or fungi from nosocomial origin may alter the pulmonary microbiome, which is usually represented by species from the genus Streptococcus, Prevotella and Veillonella, whereas in IPF patients pathogenic strains from the genus Haemophilus, Streptociccus and Neisseria may replace resident bacterial species usually tolerated by the local immunity [16,[23][24][25]. The ethiopathogenesis of COVID19 in this circumstance can be quite exclusively speculated on the basis of SARS-mediated ARDS [26].…”

Section: Introductionmentioning

confidence: 99%

Wheat and chaffs in the interpretation of the current COVID19 outbreak in Italy

Chirumbolo

Bjørklund

2020

VirusDis.

View full text Add to dashboard Cite

The COVID19 outbreak in Italy is still a big concern. The Italian Government has recommended citizens to respect faithfully any compulsory legal disposition in order to stay home and so contributing in escaping viral contacts and slowing down epidemic. Emergency has raised a widely animated debate about how to read and comprehend the daily case numbers, the medical and caregivers availability, the needs to swab asymptomatic subjects. In this review the authors discuss about the many wheat and chaffs of how this virus disease is addressed .

show abstract

Community-acquired Pneumonia and Hospital-acquired Pneumonia

Cited by 197 publications

References 58 publications

Network pharmacology to dissect the mechanisms of Yinlai Decoction for pneumonia

Network pharmacology to dissect the mechanisms of Yinlai Decoction for pneumonia

Association between FCGR2A rs1801274 and MUC5B rs35705950 variations and pneumonia susceptibility

Wheat and chaffs in the interpretation of the current COVID19 outbreak in Italy

Contact Info

Product

Resources

About