Community-acquired MRSA: A Notable Adversary

Francis, J. Sullivan; Carroll, Karen C.

doi:10.1097/01.smj.0000184802.96994.62

Cited by 2 publications

(5 citation statements)

References 20 publications

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“…The studies, performed at medical centers in Springfield, MA [13], Denver, CO [14], and Morristown, NJ [15], were found to vary significantly with respect to both the average fraction of CA-MRSA among all S. aureus (ranging from 28% to 54% of infections), as well as with respect to the estimated plateau: the peak proportion of CA-MRSA among all S. aureus infections in the study from Denver, CO was estimated at 83%, in Morristown, NJ at 50%, and in Springfield, MA at 78%. Based on these results, the meta-analytic plateau for the fraction of CA-MRSA out of all S. aureus infections is estimated to be 65% (standard error: 11%).…”

Section: Resultsmentioning

confidence: 99%

“…The individual studies vary with respect to this limiting fraction: in Springfield, MA [13], it was estimated at 78%, in Denver, CO [14] at 83% and in Morristown, NJ [15] at 50%.…”

Section: Resultsmentioning

confidence: 99%

“…[27], differences among the three studies of CA-MRSA infections as a proportion of all S. aureus infections (Figure 3) may relate, in part, to differences in patient populations and case definitions. The case series in Morristown, NJ [15] and Springfield, MA [13] only included children while the study from Denver, CO [14] included both children and adults. Similarly, the New Jersey study was restricted to patients in the emergency department (ED) and the denominator was all SSTI ED patients; this was deemed appropriate as the vast majority of SSTIs in an ED are in fact caused by S. aureus .…”

Section: Resultsmentioning

confidence: 99%

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Epidemics of Community-Associated Methicillin-Resistant Staphylococcus aureus in the United States: A Meta-Analysis

et al. 2013

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Staphylococcus aureus is the most frequent cause of skin and soft tissue infections in humans. Methicillin-resistant strains of S. aureus (MRSA) that emerged in the 1960s presented a relatively limited public health threat until the 1990s, when novel community-associated (CA-) MRSA strains began circulating. CA-MRSA infections are now common, resulting in serious and sometimes fatal infections in otherwise healthy people. Although some have suggested that there is an epidemic of CA-MRSA in the U.S., the origins, extent, and geographic variability of CA-MRSA infections are not known. We present a meta-analysis of published studies that included trend data from a single site or region, and derive summary epidemic curves of CA-MRSA spread over time. Our analysis reveals a dramatic increase in infections over the past two decades, with CA-MRSA strains now endemic at unprecedented levels in many US regions. This increase has not been geographically homogeneous, and appears to have occurred earlier in children than adults.

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Section: Resultsmentioning

confidence: 99%

“…The individual studies vary with respect to this limiting fraction: in Springfield, MA [13], it was estimated at 78%, in Denver, CO [14] at 83% and in Morristown, NJ [15] at 50%.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Epidemics of Community-Associated Methicillin-Resistant Staphylococcus aureus in the United States: A Meta-Analysis

et al. 2013

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“…Community-acquired MRSA (CA-MRSA) strains have recently become more virulent (10), causing life-threatening diseases such as necrotizing pneumonia, necrotizing fasciitis, purpura fulminans, and pyomyositis (11,12). CA-MRSA is showing a propensity not only to spread rapidly in communities but also to spread into hospitals.…”

Section: Introductionmentioning

confidence: 99%

“…Since the identification of nosocomial MRSA in the 1960s (8), strategies to prevent the spread of MRSA via hospitals has failed because most traditional antistaphylococcal agents are no longer highly effective against MRSA (9). Community-acquired MRSA (CA-MRSA) strains have recently become more virulent (10), causing life-threatening diseases such as necrotizing pneumonia, necrotizing fasciitis, purpura fulminans, and pyomyositis (11,12). CA-MRSA is showing a propensity not only to spread rapidly in communities but also to spread into hospitals.…”

Section: Introductionmentioning

confidence: 99%

Community-Acquired Methicillin-Resistant Staphylococcus aureus (CA-MRSA) Colonization and Infection in Intravenous and Inhalational Opiate Drug Abusers

El-Sharif

2008

Exp Biol Med (Maywood)

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Methicillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen in hospital-acquired and community-acquired infections. We hypothesized that drug abuse is a risk factor for community-acquired MRSA (CA-MRSA) infection, and we employed a rapid multiplex PCR technique for MRSA identification. The study was conducted on MRSA isolates from 60 opiate addicts (intravenous and inhalational drug users) to detect the rate and location of MRSA colonization and infection among them in comparison to 60 non-addict patients and 15 healthy volunteer controls. The proportion of addicts with MRSA colonization (and/or infection) was significantly higher than non-addict patients with MRSA colonization. MRSA colonization was associated with infection in 58% of MRSA-colonized addicts. The MRSA nasal carriage in the addicts was significantly higher than MRSA carriage elsewhere, whether in the addicts group or in the non-addict patients group. Moreover, the nasopharyngeal carriage rate of MRSA among addicts was significantly higher than among the non-addict patients. Increasing the duration of addiction resulted in a significant increase in CA-MRSA colonization in opiate addicts. Both inhalational and intravenous drug use led to significant MRSA colonization in the addict population. In conclusion, this study demonstrated how drug abusers, a high-risk group for infections with MRSA, could be a source or a reservoir of CA-MRSA infection in the non-addict population.

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Community-acquired MRSA: A Notable Adversary

Cited by 2 publications

References 20 publications

Epidemics of Community-Associated Methicillin-Resistant Staphylococcus aureus in the United States: A Meta-Analysis

Epidemics of Community-Associated Methicillin-Resistant Staphylococcus aureus in the United States: A Meta-Analysis

Community-Acquired Methicillin-Resistant Staphylococcus aureus (CA-MRSA) Colonization and Infection in Intravenous and Inhalational Opiate Drug Abusers

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