Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat

Zetola, Nicola M.; Francis, J. Sullivan; Nuermberger, Eric L.; Bishai, William R.

doi:10.1016/s1473-3099(05)70112-2

Cited by 716 publications

(589 citation statements)

References 123 publications

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“…The SCCmec type IVA strains were more resistant than type IV in our setting. In contrast to the study results of USA, we had only one PVL positive strain [11]. This may be due to the predominance of colonized patients in our data set, exclusion of outpatients or differences between the rates of different countries or the time frame of data collection [29].…”

Section: Discussionmentioning

confidence: 92%

“…About 43.9% of HA-MRSA and 36.4% of CA-MRSA were of SCCmec type IV/IVA. In USA, HA-MRSA primarily harbors SCCmec types I, II, III, and occasionally IV and CA-MRSA are predominantly of the SCCmec type IV [11]. In Geneva, another Swiss town, the most frequent MRSA strains were of SCCmec type I (86%) followed by type IV (11%), whereas other types were detected only on rare occasions [25].…”

Section: Discussionmentioning

confidence: 99%

“…Type IV is present in many more genetic backgrounds than other types suggesting an enhanced mobility [7][8][9]. In contrast to HA-MRSA, community-associated MRSA (CA-MRSA) strains are commonly susceptible to the majority of non-b-lactam antibiotics, frequently expressing genes encoding for PVL and are predominantly of the SCCmec types IV and V, and present multiple patterns by pulsedfield gel electrophoresis [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Emergence of SCCmec Type IV as the Most Common Type of Methicillin-Resistant Staphylococcus aureus in a University Hospital

et al. 2008

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Emergence of SCCmec Type IV as the Most Common Type of Methicillin-Resistant Staphylococcus aureus in a University Hospital

et al. 2008

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“…Moreover, presence of toxins and virulence factors may mediate greater degrees of airway inflammation. 29,30 The present study is unprecedented in Brazil. It determined the relationship between clinical data and chronic colonization with MRSA, an emergent bacterium in CF cases for which greater understanding of the impact of chronic infection is needed.…”

Section: Discussionmentioning

confidence: 99%

Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study

et al. 2017

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CONTEXT AND OBJECTIVE: The prevalence of a variety of potentially pathogenic microorganisms in cystic fibrosis patients, such as methicillin-resistant Staphylococcus aureus (MRSA), has increased over the past decade. Given the increasing prevalence of MRSA and the few data available in the literature, better understanding of the clinical repercussions of colonization by this bacterium in cystic fibrosis patients becomes essential. This study aimed to evaluate the repercussions of chronic colonization by MRSA in cystic fibrosis patients. DESIGN AND SETTING: Retrospective cohort study from January 2004 to December 2013 in a cystic fibrosis reference center. METHODS: Each patient with cystic fibrosis was evaluated for nutritional status (body mass index, BMI, and BMI percentile), pulmonary function and tomographic abnormalities (modified Bhalla scores) at the time of chronic colonization by MRSA or methicillin-susceptible Staphylococcus aureus (MSSA) and throughout the study period. RESULTS: Twenty pairs of patients were included. There were no significant differences between the groups regarding nutritional characteristics. Spirometric data showed a trend towards greater obstruction of the airways in patients with MRSA. Patients with MRSA presented greater structural damage to their lungs, demonstrated not only by the total Bhalla score but also by its parameters individually. CONCLUSIONS: Patients colonized by MRSA presented greater functional and structural respiratory impairment at the time of chronic colonization. Disease progression was also faster in patients chronically colonized by MRSA than in those with MSSA. This was shown through comparisons that avoided possible confounding variables.

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“…However, some Staphylococcus strains resistant to glycopeptides have been reported in Brazil and other countries. Community-acquired MRSA is also increasing (Zetola et al, 2005). The proportion of enterococci resistant to vancomycin continues to rise in hospital settings, with the overwhelming majority of infections due to Enterococcus faecium (NNIS, 2004).…”

Section: Introductionmentioning

confidence: 99%

Antibiotic-resistant bacteria inhibited by extracts and fractions from Brazilian marine sponges

Marinho¹,

Muricy²,

Silva³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Bactérias resistentes a antibióticos inibidas por extratos e frações de esponjas marinhas do Brasil". O número crescente de bactérias resistentes aos antibióticos tem se tornado um sério problema médico nos últimos anos. As esponjas marinhas são uma fonte rica em compostos bioativos e muitas espécies podem ser úteis para o desenvolvimento de novos antimicrobianos. Esse estudo descreve uma triagem in vitro de esponjas para a pesquisa de novas substâncias contra bactérias resistentes. Os extratos de esponjas foram testados sobre 44 estirpes bacterianas, incluindo quatorze resistentes a antibióticos. Dez entre doze espécies de esponjas apresentaram atividade em um ou mais bioensaios. Os extratos aquosos de Cinachyrella sp. e Petromica citrina apresentaram um amplo espectro de ação sobre estirpes bacterianas resistentes, tais como, Staphylococcus aureus, Staphylococcus coagulase-negativos e Enterococcus faecalis. O extrato aquoso de P. citrina foi fracionado e a fração aquosa apresentou atividade inibitória sobre estirpes de Staphylococcus. Esta fração, na concentração do CMI (16 μg/mL), demonstrou efeito bactericida sobre células de S. aureus na fase exponencial de crescimento. O mecanismo de ação da fração ainda não foi elucidado, mas nós observamos que esta afeta a síntese protéica de Staphylococcus. Nossos resultados demonstraram pela primeira vez que Petromica citrina é uma fonte potencial de novas drogas para o tratamento de infecções causadas por bactérias resistentes. Unitermos: atividade antibacteriana, bactéria resistente a antibióticos, esponjas marinhas, Petromica citrina. ABSTRACT:The growing number of bacterial strains resistant to conventional antibiotics has become a serious medical problem in recent years. Marine sponges are a rich source of bioactive compounds, and many species can be useful for the development of new antimicrobial drugs. This study reports the in vitro screening of marine sponges in the search for novel substances against antibiotic-resistant bacteria. Sponge extracts were tested against 44 bacterial strains, including fourteen antibiotic-resistant strains. Ten out of the twelve sponge species studied showed activity in one or more of the bioassays. Aqueous extracts of Cinachyrella sp. and Petromica citrina showed a large action spectrum over resistant-bacteria such as Staphylococcus aureus, coagulase-negative staphylococci and Enterococcus faecalis. Aqueous extract of P. citrina was fractioned and aqueous fraction showed a greatest inhibitory activity on Staphylococcus strains. In addition, this fraction demonstrated a bactericidal effect on exponentially growing S. aureus cells at the MIC (16 µg/ mL). The mechanism of action of bioactive fraction is still unclear, but we showed that it affect protein biosynthesis of Staphylococcus. Our results demonstrated for the first time that P. citrina is a potential source of new drugs for the treatment of infections by antibiotic-resistant bacteria.

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Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat

Cited by 716 publications

References 123 publications

Emergence of SCCmec Type IV as the Most Common Type of Methicillin-Resistant Staphylococcus aureus in a University Hospital

Emergence of SCCmec Type IV as the Most Common Type of Methicillin-Resistant Staphylococcus aureus in a University Hospital

Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study

Antibiotic-resistant bacteria inhibited by extracts and fractions from Brazilian marine sponges

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