Community‐acquired methicillin‐resistant <i>Staphylococcus aureus</i> skin infections: Report of a local outbreak and implications for emergency department care

Fleming, Scott W.; Brown, Lauren Hinson; Tice, Sarah E.

doi:10.1111/j.1745-7599.2006.00129.x

Cited by 12 publications

(6 citation statements)

References 8 publications

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“…Clinicians should be aware of the major high-risk groups for CA-MRSA. Outbreaks of any pyoderma, soft tissue abscesses, and recurrent skin infections justify the investigation for PVLpositive S. aureus/CA-MRSA (Fleming et al, 2006), especially with the patient's history containing information as mentioned above. Although there is no definite proof for PVL being the ultimate cause of deep skin infections, it seems to be a highly informative epidemiological marker for severe infections and, in some cases, CA-MRSA.…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus in Dermatology Outpatients with Special Emphasis on Community-Associated Methicillin-Resistant Strains

Jappe

Heuck

Strommenger

et al. 2008

Journal of Investigative Dermatology

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Methicillin-resistant Staphylococcus aureus (MRSA) emerged as a community-associated pathogen (CA-MRSA) in the past 6 years. This prospective study investigated dermatology outpatients with inflammatory skin diseases, leg ulcers, and skin infections for Panton-Valentine leukocidin (PVL)-positive S. aureus, often associated with deep skin infection. In case of PVL positivity, molecular typing and PCR demonstration of resistance genes were performed. Out of 248 patients, 130 carried S. aureus, 24 being lukS-PV lukF-PV positive. Eighteen were MRSA, 11 of them belonging to the multilocus sequence typing clonal complex (CC)5, 1 to CC45, and 2/18 to CC8. Out of 18 patients, 4 were CA-MRSA containing lukS-PV lukF-PV as an important trait of CA-MRSA. Out of four CA-MRSA isolates, two were of type ST080 containing far-1 coding for fusidic acid (FUS) resistance and two were FUS sensitive (ST152 and ST001). The FUS-sensitive CA-MRSA, which corresponded to the CA-MRSA of ST001 from the United States, was detected in Germany for the first time, indicating that dermatologists are first in line to detect CA-MRSA. In contrast to CA-MRSA from other continents, far-1-coded FUS resistance represents a typical marker for the widespread CA-MRSA ST080 in Europe, especially in Germany. The significant risk factor for the acquisition of CA-MRSA was visits to foreign countries and/or professional or private contacts with foreigners.

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Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus in Dermatology Outpatients with Special Emphasis on Community-Associated Methicillin-Resistant Strains

Jappe

Heuck

Strommenger

et al. 2008

Journal of Investigative Dermatology

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“…In one report, an emergency department (ED) patient recently released from a correctional setting with a CA‐MRSA SSTI led a group of NPs to perform a retrospective chart review to identify a point‐prevalence of CA‐MRSA within their ED and outpatient clinics. These practitioners noted a 10‐week CA‐MRSA prevalence of 16.3% among tissue or wound cultures (Fleming, Brown, & Tice, 2006).…”

Section: Np Researchmentioning

confidence: 99%

Epidemiology, clinical manifestations, and treatment options for skin and soft tissue infection caused by community‐acquired methicillin‐resistant Staphylococcus aureus

Farley

2008

Journal of the American Academy of Nurse Practitioners

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Purpose: This article reviews the evolving epidemiology of community-acquired methicillinresistant Staphylococcus aureus (CA-MRSA) and the appropriate outpatient management of CA-MRSA skin and soft tissue infection. Further, the paper will provide the basis upon which an individualized patient educational plan may be developed. Data Sources:To complete this review, a search of English language publications was conducted through Medline and CINAHL databases . Conclusions:The epidemiology of CA-MRSA is becoming increasingly complex. Research that addresses the impact of this organism in high-risk populations and within families is urgently needed. Implications for Practice:Nurse practitioners must remain informed of the epidemiology of common and emerging drug-resistant organisms in their patient populations.

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“…In the early 2000s, a rapid increase in the detection of CA-MRSA isolates occurred globally, including Brazil and a number of clones were documented ( Naas et al 2005 , Ribeiro et al 2005 , Takizawa et al 2005 , Fleming et al 2006 , Klevens et al 2006 ) (Table II). In the USA, the ST1-SCC mec IV isolates spread over different regions and the MW2 clone was renamed USA400.…”

mentioning

confidence: 99%

The multifaceted resources and microevolution of the successful human and animal pathogen methicillin-resistant Staphylococcus aureus

Figueiredo

Ferreira

2014

Mem. Inst. Oswaldo Cruz

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Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important bacterial pathogens based on its incidence and the severity of its associated infections. In addition, severe MRSA infections can occur in hospitalised patients or healthy individuals from the community. Studies have shown the infiltration of MRSA isolates of community origin into hospitals and variants of hospital-associated MRSA have caused infections in the community. These rapid epidemiological changes represent a challenge for the molecular characterisation of such bacteria as a hospital or community-acquired pathogen. To efficiently control the spread of MRSA, it is important to promptly detect the mecA gene, which is the determinant of methicillin resistance, using a polymerase chain reaction-based test or other rapidly and accurate methods that detect the mecA product penicillin-binding protein (PBP)2a or PBP2’. The recent emergence of MRSA isolates that harbour a mecA allotype, i.e., the mecC gene, infecting animals and humans has raised an additional and significant issue regarding MRSA laboratory detection. Antimicrobial drugs for MRSA therapy are becoming depleted and vancomycin is still the main choice in many cases. In this review, we present an overview of MRSA infections in community and healthcare settings with focus on recent changes in the global epidemiology, with special reference to the MRSA picture in Brazil.

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Community‐acquired methicillin‐resistant Staphylococcus aureus skin infections: Report of a local outbreak and implications for emergency department care

Cited by 12 publications

References 8 publications

Staphylococcus aureus in Dermatology Outpatients with Special Emphasis on Community-Associated Methicillin-Resistant Strains

Staphylococcus aureus in Dermatology Outpatients with Special Emphasis on Community-Associated Methicillin-Resistant Strains

Epidemiology, clinical manifestations, and treatment options for skin and soft tissue infection caused by community‐acquired methicillin‐resistant Staphylococcus aureus

The multifaceted resources and microevolution of the successful human and animal pathogen methicillin-resistant Staphylococcus aureus

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