Community-acquired group B streptococcal meningitis in adults

Kassel, Merel N van; Haeringen, Koen J. van; Brouwer, Matthijs C.; Bijlsma, Merijn W.; Beek, Diederik van de

doi:10.1016/j.jinf.2019.12.002

Cited by 17 publications

(20 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This points to an increased susceptibility of older adults to invasive disease given colonization through loss of protective antibodies or loss of barrier protection in a chronically colonized site. Indeed, we previously found that GBS meningitis in adults mainly occurs in those with underlying conditions such as diabetes and CSF leakage [121].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of group B streptococcal colonization in the healthy non-pregnant population: a systematic review and meta-analysis

Kassel

Janssen

Kofman

et al. 2021

Clinical Microbiology and Infection

Self Cite

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of group B streptococcal colonization in the healthy non-pregnant population: a systematic review and meta-analysis

Kassel

Janssen

Kofman

et al. 2021

Clinical Microbiology and Infection

Self Cite

View full text Add to dashboard Cite

show abstract

“…Jackson et al reported 8 cases of GBS meningitis out of a total of 219 observed invasive GBS infections (8%) [ 8 ]. These studies suggest that patients who are immunocompromised, elderly, diabetic, or with endocarditis are at particular risk of GBS meningitis [ 6 , 9 , 10 ]. A large outbreak of GBS meningitis in Asia was reported after consumption of raw fish [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Group B Streptococcus Meningitis Associated with Acute Otitis Media in an Adult Patient

2021

View full text Add to dashboard Cite

Patient: Female, 55-year-old Final Diagnosis: Streptococcus agalactiae meningitis Symptoms: Altered mental status • seizures Medication: — Clinical Procedure: — Specialty: Infectious Diseases Objective: Unusual clinical course Background: We present a case of Group B Streptococcus ( Streptococcus agalactiae or GBS) meningitis in a non-pregnant woman that likely originated from acute otitis media. Although invasive Group B Streptococcal infections are increasing in the United States, GBS meningitis is still rare in non-pregnant adults. At the end, we discuss risk factors for this disease and data that suggest that invasive GBS infection is increasing in the adult and elderly populations of the United States. Case Report: Our patient was a 55-year-old woman with a history of juvenile rheumatoid arthritis who presented with altered mental status after failure of outpatient treatment of otitis media with oral doxycycline and steroids. Upon admission, she was initially afebrile and hemodynamically stable, but she had a rapid decline and required emergent intubation. Blood cultures grew GBS. CSF PCR analysis performed by BioFire ® FilmArray® Meningitis/Encephalitis Panel revealed GBS. Middle-ear fluid and CSF cultures drawn after 1 day of antibiotic therapy did not grow any organisms. Treatment was achieved with high-dose intravenous ceftriaxone for 14 days, and tympanoplasty. At the end of 14 days of antibiotic therapy, the patient had full neurological recovery, without any residual neurological deficits. Conclusions: GBS meningitis is classically associated with neonatal disease, but invasive GBS infection is fairly common in adults and appears to be increasing in incidence secondary to increasing populations living with diabetes, immunosuppressed conditions, and advanced age. Central nervous system infection with this organism is still rare. In this case report we describe a non-pregnant woman who presented with GBS meningitis.

show abstract

“…[2][3][4] In terms of treatment, the majority of GBS infections are fortunately still sensitive to the penicillin group of antibiotics, as well as cephalosporins and vancomycin as the alternatives. 6 Therefore, a high index of suspicion among clinicians in order to initiate the appropriate treatment timely is the key to successful treatment of GBS meningitis.…”

Section: Discussionmentioning

confidence: 99%

<p>Group B Streptococcal Meningitis in a Healthy Young Woman: A Case Report</p>

Payus¹,

Clarence²,

Ali³

2020

IJGM

View full text Add to dashboard Cite

Group B streptococcus (GBS) is a rare cause of meningitis in adults that commonly affects patients with multiple underlying comorbidities. Although it is uncommon, it typically progresses very rapidly and has a high mortality rate as compared to other causes of bacterial meningitis. Here, we report a patient with GBS meningitis who had no underlying medical illness and presented with multiple episodes of seizure within hours of developing fever. Cerebrospinal fluid analysis results were consistent with bacterial meningitis, and blood cultures grew GBS. She was treated with intravenous ceftriaxone for 2 weeks and made a great recovery without any sequalae. In conclusion, although GBS meningitis is uncommon in adults, it is a serious medical disease and associated with a high mortality rate. To the best of our knowledge, this patient represents one of the few reported cases of GBS meningitis in a previously healthy young adult.

show abstract

Community-acquired group B streptococcal meningitis in adults

Cited by 17 publications

References 72 publications

Prevalence of group B streptococcal colonization in the healthy non-pregnant population: a systematic review and meta-analysis

Prevalence of group B streptococcal colonization in the healthy non-pregnant population: a systematic review and meta-analysis

Group B Streptococcus Meningitis Associated with Acute Otitis Media in an Adult Patient

<p>Group B Streptococcal Meningitis in a Healthy Young Woman: A Case Report</p>

Contact Info

Product

Resources

About