Community acquired Acinetobacter baumannii in pediatric patients under 1 year old with a clinical diagnosis of whooping cough in Lima, Peru

Peña-Tuesta, Isaac; Valle-Vargas, Cristina del; Petrozzi-Helasvuo, Verónica; Aguilar-Luis, Miguel Ángel; Carrillo-Ng, Hugo; Silva-Caso, Wilmer; Valle-Mendoza, Juana del

doi:10.1186/s13104-021-05826-y

Cited by 6 publications

(3 citation statements)

References 28 publications

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“…A consistent minimum of about 70% of species were recovered from adult patients, while pediatric samples declined from 2016 till the end of the study to reach about 12%. Reports of resistant Acinetobacter infections in children in different hospital settings have been previously published ( 56 – 58 ), even in children under 1 year with community acquisition of A. baumanni in their upper respiratory tract ( 59 ). This indicates possible epidemiological insights into the existence of Acinetobacter not only in critical settings, but also in non-serious community-based infections in the pediatric population.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and antimicrobial resistance trends of Acinetobacter species in the United Arab Emirates: a retrospective analysis of 12 years of national AMR surveillance data

Thomsen,

Abdulrazzaq,

AlRand

2024

Front. Public Health

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IntroductionAcinetobacter spp., in particular A. baumannii, are opportunistic pathogens linked to nosocomial pneumonia (particularly ventilator-associated pneumonia), central-line catheter-associated blood stream infections, meningitis, urinary tract infections, surgical-site infections, and other types of wound infections. A. baumannii is able to acquire or upregulate various resistance determinants, making it frequently multidrug-resistant, and contributing to increased mortality and morbidity. Data on the epidemiology, levels, and trends of antimicrobial resistance of Acinetobacter spp. in clinical settings is scarce in the Gulf Cooperation Council (GCC) and Middle East and North Africa (MENA) regions.MethodsA retrospective 12-year analysis of 17,564 non-duplicate diagnostic Acinetobacter spp. isolates from the United Arab Emirates (UAE) was conducted. Data was generated at 317 surveillance sites by routine patient care during 2010–2021, collected by trained personnel and reported by participating surveillance sites to the UAE National AMR Surveillance program. Data analysis was conducted with WHONET.1ResultsSpecies belonging to the A. calcoaceticus-baumannii complex were mostly reported (86.7%). They were most commonly isolated from urine (32.9%), sputum (29.0%), and soft tissue (25.1%). Resistance trends to antibiotics from different classes during the surveillance period showed a decreasing trend. Specifically, there was a significant decrease in resistance to imipenem, meropenem, and amikacin. Resistance was lowest among Acinetobacter species to both colistin and tigecycline. The percentages of multidrug-resistant (MDR) and possibly extensively drug-resistant (XDR) isolates was reduced by almost half between the beginning of the study in 2010 and its culmination in 2021. Carbapenem-resistant Acinetobacter spp. (CRAB) was associated with a higher mortality (RR: 5.7), a higher admission to ICU (RR 3.3), and an increased length of stay (LOS; 13 excess inpatient days per CRAB case), as compared to Carbapenem-susceptible Acinetobacter spp.ConclusionCarbapenem-resistant Acinetobacter spp. are associated with poorer clinical outcomes, and higher associated costs, as compared to carbapenem-susceptible Acinetobacter spp. A decreasing trend of MDR Acinetobacter spp., as well as resistance to all antibiotic classes under surveillance was observed during 2010 to 2021. Further studies are needed to explore the reasons and underlying factors leading to this remarkable decrease of resistance over time.

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Section: Discussionmentioning

confidence: 99%

Epidemiology and antimicrobial resistance trends of Acinetobacter species in the United Arab Emirates: a retrospective analysis of 12 years of national AMR surveillance data

Thomsen,

Abdulrazzaq,

AlRand

2024

Front. Public Health

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“…(2, 27) El gen OXA-58 no es muy frecuente en Latinoamérica, aunque se han reportado aislamientos en Brasil y Chile, no obstante en Chile se reporta el gen OXA-219 proveniente de una cepa ST15, el cual podría contribuir a la resistencia intrínseca del microorganismo. (9,21,25) En México, se ha identificado el gen OXA-214 que se encuentra en el cromosoma de Acinetobacter sp y se han reportado nuevas variantes: OXA-215, OXA-264, OXA-265 y OXA-575 pertenecientes A. haemolyticus, es importante destacar que el gen OXA-575 guarda una alta simlitud del 97,85 % con OXA-214.…”

Section: Discussionunclassified

Carbapenem-resistant Acinetobacter baumannii complex: a review in Latin America

Manobanda Nata,

Jaramillo Ruales

2023

Salud, Ciencia y Tecnología

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Introducción: Acinetobacter baaumannii complex es un patógeno capaz de producir infecciones intrahospitalarias, en pacientes inmunodeprimidos, el microorganismo es resistente a los carbapenémicos y dentro de las unidades de salud es difícil de controlarlo. Métodos: Es un estudio de revisión bibliográfica tipo documental sobre la resistencia a los carbapenémicos de Acinetobacter baaumannii complex en Latinoamérica, utilizando diferentes bases de datos: Pubmed, Google Académico, Scielo, Dialnet y Redalyc para la selección de artículos se aplicó los criterios de inclusión y exclusión, además para encontrar valores significativos se realizó la prueba t-Student. Resultados: La resistencia a los carbapenémicos en A. baumannii complex se reporta en todos los países de Latinoamérica, predominando el grupo de genes de familia de las oxacilinas (OXA-23 y OXA-51), a diferencia de las metalo- beta-lactamasas no son muy frecuentes y se ha identificado en menor cantidad de aislamientos, no obstante, Perú y Argentina mostraron altos porcentajes de resistencia, además la mayoría de los aislamientos positivos del microorganismo proviene de aspirados traqueales. Conclusiones: La revisión permite conocer la situación de la resistencia a los carbapenémicos en Latinoamérica, los diferentes genes identificados han otorgado gran variedad de resistencia al microorganismo, es necesario mantener la vigilancia de este microorganismo con el fin de investigar nuevas alternativas terapéuticas frente a este patógeno.

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“…The reaction mixture was 7.6 µL of nuclease-free water, 2.4 µL of buffer solution with 25 mM of Mg 2+ , 2.0 µL of Faststart Enzyme, 1 µL of each OXA-51-specific primer in 1 mM concentration, 1 µL of probe, and 5 µL of DNA. The amplification conditions were 95 • C for 10 min, followed by 55 cycles at 95 • C for 5 s, 60 • C for 5 s, and 72 • C for 15 s. LightCycler 2.0 was used, and data were analyzed with LightCycler 4.1 software (Roche Diagnostics, Mannheim, Germany) [44].…”

Section: Pcr Amplification Real-time Polymerase Chain Reaction (Real-...mentioning

confidence: 99%

Identification and Clinical Characteristics of Community-Acquired Acinetobacter baumannii in Patients Hospitalized for Moderate or Severe COVID-19 in Peru

Silva-Caso,

Pérez-Lazo,

Aguilar-Luis

et al. 2024

Antibiotics

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Acinetobacter baumannii has been described as a cause of serious community-acquired infections in tropical countries. Currently, its implications when simultaneously identified with other pathogens are not yet adequately understood. A descriptive study was conducted on hospitalized patients with a diagnosis of moderate/severe SARS-CoV-2-induced pneumonia confirmed via real-time RT-PCR. Patients aged > 18 years who were admitted to a specialized COVID-19 treatment center in Peru were selected for enrollment. A. baumannii was detected via the PCR amplification of the blaOXA-51 gene obtained from nasopharyngeal swabs within 48 h of hospitalization. A total of 295 patients with COVID-19 who met the study inclusion criteria were enrolled. A. baumannii was simultaneously identified in 40/295 (13.5%) of COVID-19-hospitalized patients. Demographic data and comorbidities were comparable in both Acinetobacter-positive and -negative subgroups. However, patients identified as being infected with Acinetobacter were more likely to have received outpatient antibiotics prior to hospitalization, had a higher requirement for high-flow nasal cannula and a higher subjective incidence of fatigue, and were more likely to develop Acinetobacter-induced pneumonia during hospitalization. Conclusions: The group in which SARS-CoV-2 and A. baumannii were simultaneously identified had a higher proportion of fatigue, a higher frequency of requiring a high-flow cannula, and a higher proportion of superinfection with the same microorganism during hospitalization.

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Community acquired Acinetobacter baumannii in pediatric patients under 1 year old with a clinical diagnosis of whooping cough in Lima, Peru

Cited by 6 publications

References 28 publications

Epidemiology and antimicrobial resistance trends of Acinetobacter species in the United Arab Emirates: a retrospective analysis of 12 years of national AMR surveillance data

Epidemiology and antimicrobial resistance trends of Acinetobacter species in the United Arab Emirates: a retrospective analysis of 12 years of national AMR surveillance data

Carbapenem-resistant Acinetobacter baumannii complex: a review in Latin America

Identification and Clinical Characteristics of Community-Acquired Acinetobacter baumannii in Patients Hospitalized for Moderate or Severe COVID-19 in Peru

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