Communicative deficits in agenesis of the corpus callosum: Nonliteral language and affective prosody

Paul, Lynn K.; Lancker-Sidtis, Diana Van; Schieffer, Beatrix; Dietrich, R B; Brown, Warren S.

doi:10.1016/s0093-934x(03)00062-2

Cited by 145 publications

(112 citation statements)

References 60 publications

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“…As of yet, the pattern of consistent cognitive deficits in ACC has not been fully described. However, our results thus far, and those appearing in the research literature, suggest that high-functioning adults with ACC typically have moderate but detectable deficits in the following areas: interhemispheric transfer of complex sensory information and learning [15][16][17][18][19][20]; bimanual motor coordination [18,21,22]; complex novel problem-solving [13,14,[23][24][25][26]; processing of subtle phonetic and semantic aspects of language [13,[27][28][29][30][31][32]; comprehension of second-order meanings of language [33][34][35]; and psychosocial understanding and behavior [14,35]. Since the individuals with ACC that we have studied have complete ACC, normal IQs, and few, if any, other structural brain abnormalities, we refer to this form of ACC as Primary ACC.…”

Section: Introductionmentioning

confidence: 79%

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Social and Behavioral Problems of Children with Agenesis of the Corpus Callosum

Badaruddin

Andrews

Bölte

et al. 2007

Child Psychiatry Hum Dev

136

115

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Archival data from a survey of parent observations was used to determine the prevalence of social and behavioral problems in children with agenesis of the corpus callosum (ACC). Parent observations were surveyed using the Child Behavior Checklist (CBCL) for 61 children with ACC who were selected from the archive based on criteria of motor development suggesting a relatively high general level of functioning. Younger children with ACC (ages 2-5) were rated as primarily having problems with sleep. Older children with ACC (ages 6-11) manifested problems in attention, social function, thought, and somatic complaints. The older children with ACC were also compared to CBCL data from 52 children with autism who were selected from a previous study. Children with ACC were generally less impaired than children with autism on nearly all scales, with significantly less severe problems in the areas of attention, anxiety/depression, social function, and unusual thoughts. A further questionnaire related to diagnostic criteria for autism indicated that some children with ACC had traits that are among those that contribute to the diagnosis of autism within the domains of social interaction and social communication, but fewer who manifest repetitive and restricted behaviors.

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Section: Introductionmentioning

confidence: 79%

“…A number of studies have demonstrated that individuals with ACC have difficulty on tasks involving complex novel problem solving [13,14,[23][24][25][26][67][68][69]. In addition, individuals with ACC have deficits in comprehension of the second-order meanings of language [33][34][35].…”

Section: Cbcl Resultsmentioning

confidence: 99%

Social and Behavioral Problems of Children with Agenesis of the Corpus Callosum

Badaruddin

Andrews

Bölte

et al. 2007

Child Psychiatry Hum Dev

136

115

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“…In contrast, executive functions, reading and spelling skills were relatively preserved. Studies examining social functioning in individuals with AgCC report a range of impairments, such as reduced understanding of jokes and humor (Brown, Paul, Symington, & Dietrich, 2005), proverb and non-literal items (Paul, Van Lancker-Sidtis, Schieffer, Dietrich, & Brown, 2003), complex social scenes (Brown & Paul, 2000;Paul, Schieffer, & Brown, 2004;Turk, Brown, Symington, & Paul, 2010), integration of social information from multiple sources (e.g., paralinguistic cues, nonliteral language; Symington, Paul, Symington, Ono, & Brown, 2010), story-generation skills (Paul et al, 2004), and difficulties experiencing and thinking about complex but not basic emotions in the context of social interactions (L. B. Anderson, Paul, & Brown, 2017).…”

Section: [Insert Figure 1 Here]mentioning

confidence: 99%

A Neuropsychological Profile for Agenesis of the Corpus Callosum? Cognitive, Academic, Executive, Social, and Behavioral Functioning in School-Age Children

Siffredi

Anderson

McIlroy

et al. 2018

J Int Neuropsychol Soc

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Re: A neuropsychological profile for agenesis of the corpus callosum? Cognitive, academic, executive, social and behavioral functioning in school-age children JINS#-17- RR-108Thank you for accepting our manuscript for publication with minor revisions.We would like to thank again the reviewers for their positive and constructive comments.Below we provide responses to each reviewer comment. The associated amendments in the manuscript are highlighted in red (and the amendments related to the previous revisions are highlighted in yellow). Best wishes, Dr Vanessa Siffredi and Dr Megan Spencer-Smith Reviewer 1Comment: The authors have been very responsive to feedback provided by the Reviewers and Action Editor. I have no further suggestions for revision.Response: Thank you. Reviewer 2Comment: You have been very diligent in responding to the questions I raised in my earlier review-thank you! Response: Thank you.Comment: My only lingering concern is whether this report will be really useful, and to whom. The heterogeneity of callosal agenesis both behaviorally and genetically makes it difficult to use the data with reference to particular individuals, although suppose the study can at least indicate the likely range of presentation. You suggest that heterogeneity is a positive feature, although even the heterogeneity is limited given the source of the data. Even so, this study is perhaps a useful contrast with the Quebec studies, where there was relative homogeneity, especially genetically.Response: This report provides crucial information for clinicians (neonatologists, neurologists, and neuropsychologists) Comment: From my perspective, the most useful observation was the even distribution of handedness, ignored in the first version and skipped over here. There is quite a lot of evidence that handedness is random in the absence of any congenital bias, and the data now seem to suggest that it is indeed random among those with agenesis of the corpus callosum. Could this mean that handedness itself depends on normal development of the corpus callosum? To me at least, this is something that does need further comment. (Raymond, Pontier, Dufour, Moller, 1996) 56% (e.g., Lábadi & Beke, 2017;Sauerwein & Lassonde, 1994;Chiarello, 1980) Response: In the general population, the percentage of left-handedness is around 10 to 13%

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“…For example, Bridgman, Brown, Spezio, Leonard, Adolphs, and Paul (2014) found that AgCC patients performed poorly when asked to name the emotion displayed in a series of faces. Similarly, AgCC patients perform worse than control subjects in understanding emotional-prosodic cues (Paul, Van Lancker-Sidtis, Schieffer, Dietrich & Brown, 2003), in understanding and discussing socially complex scenes (Paul, Schieffer & Brown, 2004), and understanding humour (Brown, Paul, Symington & Dietrich, 2005) --despite having equivalent IQs to control participants.…”

Section: Discussionmentioning

confidence: 96%

Social responsiveness to inanimate entities: Altered white matter in a ‘social synaesthesia’

et al. 2016

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, M (2016) Social responsiveness to inanimate entities: altered white matter in a 'social synaesthesia '. Neuropsychologia, This version is available from Sussex Research Online: http://sro.sussex.ac.uk/64745/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. 1 Social responsiveness to inanimate entities:Alte ed hite atte i a so ial s aesthesia ABSTRACTJudgments about personalities and social traits can be made by relatively brief exposure to animate living things. Here we show that unusual architecture in the microstructure of the human brain is related to atypical mental projections of personality and social structure onto things that are neither living nor animate. Our participants experience automatic, life-long and consistent crossmodal associations between language sequences (e.g., letters, numbers and days) and complex personifications (e.g., A is a businessman; 7 a good-atu ed o a . Pa ti ipa ts ith this O di al Li guisti Pe so ifi atio "i e & Hu a d, hi h e des i e he e as a fo of so ial synaesthesia, showed lower fractional anisotropy (FA) values in five clusters at whole-brain significance, compared with non-synaesthetes (in the pre-postcentral gyrus/ dorsal corticospinal tract, left superior corona radiata, and the genu, body and left side of the corpus callosum). We found no regions of the brain with increased FA in synaesthetes. A number of these regions with reduced FA play a role in social responsiveness, and our study is the first to show that unusual differences in white matter microstructure in these regions is associated with compelling feelings of social cohesion and personality towards non-animate entities. We show too that altered patterns of connectivity known to t pif s aesthesia a e ot li ited to a ia ts i ol i g a e gi g of the se ses , ut also e te d to 2 what might be thought of as a cogno-social variant of synaesthesia, linking language and personality attributes in this surprising way.

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Communicative deficits in agenesis of the corpus callosum: Nonliteral language and affective prosody

Cited by 145 publications

References 60 publications

Social and Behavioral Problems of Children with Agenesis of the Corpus Callosum

Social and Behavioral Problems of Children with Agenesis of the Corpus Callosum

A Neuropsychological Profile for Agenesis of the Corpus Callosum? Cognitive, Academic, Executive, Social, and Behavioral Functioning in School-Age Children

Social responsiveness to inanimate entities: Altered white matter in a ‘social synaesthesia’

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