Communication between circadian clusters: The key to a plastic network

Beckwith, Esteban J.; Ceriani, M. Fernanda

doi:10.1016/j.febslet.2015.08.017

Cited by 35 publications

(34 citation statements)

References 98 publications

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“…This view was recently challenged, as several groups showed that the morning oscillator is not capable of coherently resetting free-running rhythms when its clock speed is genetically altered and revealed that clock neurons other than the morning oscillator (e.g., the evening oscillator) have independent control over free-running rhythms (Beckwith and Ceriani, 2015; Guo et al, 2014; Yao and Shafer, 2014). It remains unaddressed whether there is a minimal set of clock neurons that can function as a master pacemaker for the entire clock network, driving behavioral rhythms with their endogenous rhythm, despite discrepant timekeeping in the remaining neuronal oscillators.…”

Section: Resultsmentioning

confidence: 99%

The Drosophila Clock Neuron Network Features Diverse Coupling Modes and Requires Network-wide Coherence for Robust Circadian Rhythms

et al. 2016

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Summary In animals, networks of clock neurons containing molecular clocks orchestrate daily rhythms in physiology and behavior. How various types of clock neurons communicate and coordinate with one another to produce coherent circadian rhythms is not well understood. Here, we investigate clock neuron coupling in the brain of Drosophila and demonstrate that the fly’s various groups of clock neurons display unique and complex coupling relationships to core pacemaker neurons. Furthermore, we find that coordinated free-running rhythms require molecular clock synchrony not only within the well-characterized lateral clock neuron classes, but also between lateral clock neurons and dorsal clock neurons. These results uncover unexpected patterns of coupling in the clock neuron network and reveal that robust free-running behavioral rhythms require a coherence of molecular oscillations across most of the fly’s clock neuron network.

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Section: Resultsmentioning

confidence: 99%

The Drosophila Clock Neuron Network Features Diverse Coupling Modes and Requires Network-wide Coherence for Robust Circadian Rhythms

et al. 2016

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“…The six groups of PER‐TIM‐expressing neurons include the large and small ventral lateral neurons (l‐LNvs and s‐LNvs), the dorsal lateral neurons (LNds), the lateral posterior neurons (LPNs) and three groups of dorsal neurons (DN1s, DN2s and DN3s) (Figure ) (Helfrich‐Förster et al., ; Kaneko & Hall, ). Clock neurons between and within groups use a heterogenous set of neuropeptides and neurotransmitters for signaling (reviewed in Beckwith & Ceriani, ).…”

Section: The Circadian Clock Network In Drosophila Brainmentioning

confidence: 99%

Molecular and circuit mechanisms mediating circadian clock output in the Drosophila brain

King

Sehgal

2018

Eur J of Neuroscience

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A central question in the circadian biology field concerns the mechanisms that translate ~24-hr oscillations of the molecular clock into overt rhythms. Drosophila melanogaster is a powerful system that provided the first understanding of how molecular clocks are generated and is now illuminating the neural basis of circadian behavior. The identity of ~150 clock neurons in the Drosophila brain and their roles in shaping circadian rhythms of locomotor activity have been described before. This review summarizes mechanisms that transmit time-of-day signals from the clock, within the clock network as well as downstream of it. We also discuss the identification of functional multisynaptic circuits between clock neurons and output neurons that regulate locomotor activity.

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“…Neural plasticity, broadly described as the changes in neuronal morphology 1 , cell-cell interaction 2 , and gene expression 3 , allows neurons to efficiently respond and adapt to those environmental challenges. The uniqueness of neurons is highlighted by their exceptionally complex compartmental diversity.…”

Section: Introductionmentioning

confidence: 99%

Aberrant plasticity of peripheral sensory axons in a painful neuropathy

Hirai

Mulpuri

Cheng

et al. 2017

Sci Rep

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Neuronal cells express considerable plasticity responding to environmental cues, in part, through subcellular mRNA regulation. Here we report on the extensive changes in distribution of mRNAs in the cell body and axon compartments of peripheral sensory neurons and the 3′ untranslated region (3′UTR) landscapes after unilateral sciatic nerve entrapment (SNE) injury in rats. Neuronal cells dissociated from SNE-injured and contralateral L4 and L5 dorsal root ganglia were cultured in a compartmentalized system. Axonal and cell body RNA samples were separately subjected to high throughput RNA sequencing (RNA-Seq). The injured axons exhibited enrichment of mRNAs related to protein synthesis and nerve regeneration. Lengthening of 3′UTRs was more prevalent in the injured axons, including the newly discovered alternative cleavage and polyadenylation of NaV1.8 mRNA. Alternative polyadenylation was largely independent from the relative abundance of axonal mRNAs; but they were highly clustered in functional pathways related to RNA granule formation in the injured axons. These RNA-Seq data analyses indicate that peripheral nerve injury may result in highly selective mRNA enrichment in the affected axons with 3′UTR alterations potentially contributing to the mechanism of neuropathic pain.

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Communication between circadian clusters: The key to a plastic network

Cited by 35 publications

References 98 publications

The Drosophila Clock Neuron Network Features Diverse Coupling Modes and Requires Network-wide Coherence for Robust Circadian Rhythms

The Drosophila Clock Neuron Network Features Diverse Coupling Modes and Requires Network-wide Coherence for Robust Circadian Rhythms

Molecular and circuit mechanisms mediating circadian clock output in the Drosophila brain

Aberrant plasticity of peripheral sensory axons in a painful neuropathy

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