Commonly Consumed Beverages in Daily Life: Do They Cause Atrial Fibrillation?

Turagam, Mohit K.; Velagapudi, Poonam; Kocheril, Abraham G.; Alpert, Martin A.

doi:10.1002/clc.22385

Cited by 18 publications

(14 citation statements)

References 58 publications

(95 reference statements)

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“…Other ingredients in EDs including "energy blends" and herbs could potentially trigger arrhythmias as well [15]. Atrial fibrillation has been observed following acute ingestion of EDs in young adults [50]. It is unknown whether these individuals had a genetic predisposition towards arrhythmia or if ingredients in the EDs triggered the events [50].…”

Section: Supraventricular Arrhythmiamentioning

confidence: 99%

“…Atrial fibrillation has been observed following acute ingestion of EDs in young adults [50]. It is unknown whether these individuals had a genetic predisposition towards arrhythmia or if ingredients in the EDs triggered the events [50]. It is important to note that atrial fibrillation is extremely rare in the pediatric population and it almost always occurs in association with structural heart disease [51].…”

Section: Supraventricular Arrhythmiamentioning

confidence: 99%

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Cardiovascular Complications of Energy Drinks

2015

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Energy drinks (EDs) are gaining popularity every year with a broad consumer base including athletes, amateur competitors, and even those experiencing work-related fatigue. Evidence indicates that a significant number of individuals who consume EDs experience resultant morbidity and/or mortality, with a preponderance of cases involving teenagers and young adults. Adverse effects of ED consumption may occur in healthy persons, however certain individuals may be particularly susceptible to complications. At-risk populations include those of young age, the caffeine-naï ve, or caffeine-sensitive, pregnant women, competitive athletes, and those with underlying cardiovascular disease. This paper summarizes the cardiovascular complications associated with ED use and provides suggestions on consumption of these drinks in various populations.

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Section: Supraventricular Arrhythmiamentioning

confidence: 99%

Section: Supraventricular Arrhythmiamentioning

confidence: 99%

Cardiovascular Complications of Energy Drinks

2015

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“…Rather, the physician advised, not against cold drinks, but against coffee, although this was not the precipitant of the patient’s headache or dysrhythmia. Though it might be prudent for a patient with paroxysmal AF to limit caffeine ingestion, the relationship between coffee ingestion and incident AF has been called into question by a number of studies [ 34 ]. Just as in our case report, none of the five emergency physicians caring for the patients with cold-induced AF from our Pharm CAFÉ Study reported advising their patients to avoid re-exposure to ice-cold drinks.…”

Section: Discussionmentioning

confidence: 99%

Paroxysmal Atrial Fibrillation and Brain Freeze: A Case of Recurrent Co-Incident Precipitation From a Frozen Beverage

Lugovskaya

Vinson

2016

Am J Case Rep

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Patient: Male, 29Final Diagnosis: Paroxysmal atrial fibrillation • cold-stimulus headacheSymptoms: Palpitations • headacheMedication: Diltiazem • IbutilideClinical Procedure: NoneSpecialty: Emergency Medicine • Internal MedicineObjective:Unknown ethiology • Rare diseaseBackground:Episodes of paroxysmal atrial fibrillation may be precipitated by the rapid ingestion of ice-cold foods and beverages. This condition has received little research attention, and its true prevalence is poorly described. Treating physicians may not identify cold ingestion as a causal factor of paroxysmal atrial fibrillation, thus compromising both history taking and patient education.Case Report:We report a case of a healthy young-adult man who drank a slushed ice beverage that immediately induced atrial fibrillation and a brain freeze headache simultaneously. This occurred on two separate occasions, years apart. During both episodes, the acute brain freeze self-resolved quickly, but the new-onset palpitations occasioned a visit to the emergency department for diagnosis and treatment. The emergency physicians failed to make the causal link between the cold drink and the atrial dysrhythmia. Though the brain freeze headache and paroxysmal atrial fibrillation were both precipitated by rapid ingestion of an ice-cold beverage, the mediating mechanisms are distinct. We review these two cold-induced conditions, their prevalence, and their probable mechanisms.Conclusions:The recurrent simultaneous occurrence of brain-freeze headache with paroxysmal atrial fibrillation identifies the ingestion of a frozen beverage as the precipitant of the atrial dysrhythmia. Increasing physician awareness of cold ingestion as a cause of paroxysmal atrial fibrillation will improve history taking and patient education.

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“…Epidemiological evidence over the last decade has identified that metabolic syndrome, prehypertension, obesity, obstructive sleep apnea, exercise, and dietary intake of stimulants are major risk factors for AF [4,6]. However, only a small proportion of exposed individuals eventually developed AF, suggesting that a strong genetic component might be a risk factor contributing to the susceptibility of AF.…”

Section: Introductionmentioning

confidence: 99%

Identification of Potential Crucial Genes in Atrial Fibrillation: A Bioinformatic Analysis

Zhang

Huang

Wang

et al. 2020

Preprint

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Background Atrial fibrillation (AF) is clearly heritable, affecting 2-3% of the population in Europe and the USA. However, a substantial proportion of heritability is still lacking. In the present study, we aim to identify potential crucial genes associated with AF through bioinformatic analyses of public datasets.Methods Microarray data sets of GSE115574, GSE31821, GSE79768, GSE41177 and GSE14975 from the Gene Expression Omnibus (GEO) database were enrolled. After merging all microarray data and adjusted batch effect, differentially expressed genes (DEGs) were identified. Functional enrichment analyses based on Gene Ontology (GO) resource, Kyoto Encyclopedia of Genes and Genomes (KEGG) resource, Gene Set Enrichment Analysis (GSEA), Reactome Pathway Database and Disease Ontology (DO) were carried out for DEGs. Protein-protein interaction (PPI) network was constructed using the STRING database. Combined with aforementioned significant bioinformatics information, potential crucial genes were subsequently selected. The potential crucial genes coupled with corresponding predicted microRNAs involved in AF were then assessed.Result We identified 27 of DEGs with gene expression fold change (FC) ≥ 1.5 and 5 with FC ≥ 2 of AF patients compared with sinus rhythm controls. The most significantly enriched pathway was regulation of insulin-like growth factor transport and uptake by insulin-like growth factor binding proteins. IGFBP2, C1orf105, FHL2, CHGB, ATP1B4, IGFBP3, SLC26A9, CXCR4 and HTR2B were considered the potential crucial genes. Sixteen corresponding predicted microRNAs, of which 5 targeting IGFBP3 and 8 FHL2, might be associated with AF. The comparative toxicogenomics database (CTD) database showed CXCR4, IGFBP2, IGFBP3 and FHL2 had higher scores with AF.Conclusions The 9 potential crucial genes, especially CXCR4, IGFBP2, IGFBP3 and FHL2, may be associated with risk of AF. MicroRNAs targeting IGFBP3 and FHL2 may be potential biomarkers or therapeutic targets for AF. Our study provided new insights of AF into genetics, molecular pathogenesis and new therapeutic targets.

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Commonly Consumed Beverages in Daily Life: Do They Cause Atrial Fibrillation?

Cited by 18 publications

References 58 publications

Cardiovascular Complications of Energy Drinks

Cardiovascular Complications of Energy Drinks

Paroxysmal Atrial Fibrillation and Brain Freeze: A Case of Recurrent Co-Incident Precipitation From a Frozen Beverage

Identification of Potential Crucial Genes in Atrial Fibrillation: A Bioinformatic Analysis

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