Commonality in the microarchitecture of trabecular bone: A preliminary study

Zhang, Feng; Kirby, Matthew; Roy, Anuradha; Hu, Yizhong; Guo, X. Edward; Wang, Xiaodu

doi:10.1016/j.bone.2018.03.003

Cited by 15 publications

(7 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Natural bone is composed of trabecular bone surrounded by cortical bone, which creates a porous environment with 50-90% porosity and pore sizes of 1 mm. 4 An ideal bone scaffold should mimic the microenvironment of trabecular bone for cell-cell/cell-matrix interaction and have excellent space maintaining capacity to provide structural support for new bone ingrowth. It is generally accepted that the pore geometry of scaffold, including pore size, pore shape, porosity, and pore interconnecting pattern, plays an important role in cell adhesion, proliferation, and migration as well as tissue ingrowth.…”

Section: Introductionmentioning

confidence: 99%

Osteogenesis of 3D printed macro-pore size biphasic calcium phosphate scaffold in rabbit calvaria

Fan

Liu

et al. 2019

J Biomater Appl

View full text Add to dashboard Cite

To investigate the osteogenesis of macro-pore sized bone scaffolds, biphasic calcium phosphate scaffolds with accurately controlled macro-pore size (0.8, 1.2, and 1.6 mm) and identical porosity of 70% were fabricated by the 3D printing technology. Eight New Zealand rabbits were selected in the present study, while four 8-mm-diameter calvarial defects were created in each rabbit to place BCP scaffolds with different macro-pore size. The harvested specimens of four and eight weeks were used to evaluate the bone forming ability by micro CT and histological examination. All 3D-printed BCP scaffolds exhibited excellent mechanical properties and had better bone-forming ability than the control at both four and eight weeks. Among them, scaffold with 0.8 mm pore size was superior for initial bone formation and maturation, resulting in the highest value of total bone formation.

show abstract

Section: Introductionmentioning

confidence: 99%

Osteogenesis of 3D printed macro-pore size biphasic calcium phosphate scaffold in rabbit calvaria

Fan

Liu

et al. 2019

J Biomater Appl

View full text Add to dashboard Cite

show abstract

“…The implementation of 3D printing technology allowed the precise control of pore size while the morphology within the printed PCL and composite scaffolds was accomplished. As it is known, the natural bone consists of trabecular bone encircled by cortical bone, which creates a porous environment characterized by 50-90% porosity and 1 mm pore size [37,38]. Only when the microenvironment of the trabecular bone in respect of the respective cell-cell/cell-matrix interaction [38] (Fig.…”

Section: Discussionmentioning

confidence: 99%

Investigation of bone reconstruction using an attenuated immunogenicity xenogenic composite scaffold fabricated by 3D printing

et al. 2020

View full text Add to dashboard Cite

Bone is known to have a natural function to heal itself. However, if the bone damage is beyond a critical degree, intervention such as bone grafting may be imperative. In this work, the fabrication of a novel bone scaffold composed of natural bone components and polycaprolactone (PCL) using 3D printing is put forward. α1, 3-galactosyltransferase deficient pigs were used as the donor source of a xenograft. Decellularized porcine bone (DCB) with attenuated immunogenicity was used as the natural component of the scaffold with the aim to promote bone regeneration. The 3D printed DCB-PCL scaffolds combined essential advantages such as uniformity of the interconnected macropores and high porosity and enhanced compressive strength. The biological properties of the DCB-PCL scaffolds were evaluated by studying cell adhesion, viability, alkaline phosphatase activity and osteogenic gene expression of human bone marrow-derived mesenchymal stem cells. The in vitro results demonstrated that the DCB-PCL scaffolds exhibit an enhanced performance in promoting bone differentiation, which is correlated to the DCB content. Furthermore, critical-sized cranial rat defects were used to assess the effect of DCB-PCL scaffolds on bone regeneration in vivo. The results confirm that in comparison with PCL scaffolds, the DCB-PCL scaffolds can significantly improve new bone formation in cranial defects. Thus, the proposed 3D printed DCB-PCL scaffolds emerge as a promising regeneration alternative in the clinical treatment of large bone defects.

show abstract

“…Secondly, Equation 5 is tested in the design for a 3D Voronoi structure of a patient's trabecular bone, which may be used to examine the structural fragility resulting from osteoporosis 44 . As Voronoi structures have been shown to accurately model the bone microenvironment 16,24 , a Voronoi structure is designed to model a patient's trabecular bone derived from E calculated in a segment of the patient's bone microenvironment (1388 edges) 44 . However, a more detailed model would require further parameters, such as anisotropy and inhomogeneity, to increase accuracy.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…The edge length of the cubic design space has been abbreviated to L. The images of the 3D Voronoi structures have been converted to scaffolds (had a mesh wrapped around them) for illustration purposes. The environmental images displayed are from the following papers, for the lymphnodes (a) 43 , bone (b) 17,44 and kidney tumour (c) 13 .…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Two conjectures on 3D Voronoi structures: a toolkit with biomedical case studies

Todd,

Chin,

Coppens

2024

Mol. Syst. Des. Eng.

View full text Add to dashboard Cite

show abstract

Commonality in the microarchitecture of trabecular bone: A preliminary study

Cited by 15 publications

References 54 publications

Osteogenesis of 3D printed macro-pore size biphasic calcium phosphate scaffold in rabbit calvaria

Osteogenesis of 3D printed macro-pore size biphasic calcium phosphate scaffold in rabbit calvaria

Investigation of bone reconstruction using an attenuated immunogenicity xenogenic composite scaffold fabricated by 3D printing

Two conjectures on 3D Voronoi structures: a toolkit with biomedical case studies

Contact Info

Product

Resources

About