Common variations in estrogen-related genes are associated with severe large-joint osteoarthritis: a multicenter genetic and functional study

Riancho, José A.; García-Ibarbia, Carmen; Gravani, Athanasia; Raine, E.V.; Rodríguez-Fontenla, Cristina; Soto‐Hermida, Angel; Rego‐Pérez, Ignacio; Dodd, Andrew; Gómez-Reino, Juan J.; Zarrabeitia, Marı́a T.; Garcés, Carlos; Carr, Andrew; Blanco, Francisco J.; González, Antonio G.; Loughlin, John

doi:10.1016/j.joca.2010.04.002

Cited by 35 publications

(29 citation statements)

References 43 publications

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“…The rs1062033 genotype associated with higher OA risk was also associated with reduced expression of the aromatase gene in bone. These results are consistent with the hypothesis that estrogen activity may influence the development of large-joint OA (Riancho et al, 2010).…”

Section: Modulation Of Osteocyte or Chondrocyte Differentiationsupporting

confidence: 92%

The Genetics of Osteoarthritis

Miranda‐Duarte¹

2012

Principles of Osteoarthritis- Its Definition, Character, Derivation and Modality-Related Recognition

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Section: Modulation Of Osteocyte or Chondrocyte Differentiationsupporting

confidence: 92%

The Genetics of Osteoarthritis

Miranda‐Duarte¹

2012

Principles of Osteoarthritis- Its Definition, Character, Derivation and Modality-Related Recognition

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“…Several studies have examined the role of estrogens on knee OA. While results support a contribution to knee OA 39–41 , the evidence is not definitive. BMI has been found to be highly predictive of both knee OA 42, 43 and knee pain 44 and, similar to our study, BMI is generally greater in women than in men.…”

Section: Discussionmentioning

confidence: 73%

Examining sex differences in knee pain: the Multicenter Osteoarthritis Study

Glass

Segal

Sluka

et al. 2014

Osteoarthritis and Cartilage

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Objective To determine whether women experience greater knee pain severity than men at equivalent levels of radiographic knee osteoarthritis (OA). Design and Methods A cross-sectional analysis of 2712 individuals (60% women) without knee replacement or a recent steroid injection. Sex differences in pain severity at each KL grade were assessed by knee using VAS scale and WOMAC with and without adjustment for age, analgesic use, BMI, clinic site, comorbid conditions, depression score, education, race, and widespread pain (WSP) using generalized estimating equations. Effect sizes (Cohen’s d) were also calculated. Analyses were repeated in those with and without patellofemoral OA (PFOA). Results Women reported higher VAS pain at all KL grades in unadjusted analyses (d=0.21–0.31, p<0.0001–0.0038) and in analyses adjusted for all covariates except WSP (d=0.16–0.22, p<0.0001–0.0472). Pain severity differences further decreased with adjustment for WSP (d=0.10–0.18) and were significant for KL grade ≤2 (p=0.0015) and 2 (p=0.0200). Presence compared with absence of WSP was associated with significantly greater knee pain at all KL grades (d=0.32–0.52, p<0.0001–0.0008). In knees with PFOA, VAS pain severity sex differences were greater at each KL grade (d=0.45–0.62, p=0.0006–0.0030) and remained significant for all KL grades in adjusted analyses (d=0.31–0.57, p=0.0013–0.0361). Results using WOMAC were similar. Conclusions Women reported greater knee pain than men regardless of KL grade, though effect sizes were generally small. These differences increased in the presence of PFOA. The strong contribution of WSP to sex differences in knee pain suggests that central sensitivity plays a role in these differences.

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“…Another study investigating the association of four ESR1 SNPs with knee OA reported that the TAGA haplotype consisting of rs2234693, rs827421, rs1801132 and rs2228480 SNPs is associated with an increased risk of knee OA in women [87]. Recently, the CC genotype of the ESR1 rs2234693 SNP was associated with reduced knee and hip OA risk in women, but with increased risk of hip OA in men [88]. …”

Section: Genetic Determinants Of Osteoarthritismentioning

confidence: 99%

Occupational and genetic risk factors for osteoarthritis: A review

Yücesoy

Charles

Baker

et al. 2015

Work

121

111

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BACKGROUND Osteoarthritis (OA) is a multifactorial disease with strong genetic and occupational components. Although published studies have described several risk factors for OA, very few studies have investigated the occupational and genetic factors that contribute to this debilitating condition. OBJECTIVE To describe occupational and genetic factors that may contribute to the risk of developing (OA). METHODS A literature search was conducted in PubMed using the search terms osteoarthritis, occupation, work, and genetics. RESULTS Heavy physical work load was the most common occupational risk factor for OA in several anatomical locations. Other factors include kneeling and regular stair climbing, crawling, bending and whole body vibration, and repetitive movements. Numerous studies have also shown the influence of genetic variability in the pathogenesis of OA. Genetic variants of several groups of genes e.g., cartilage extracellular matrix structural genes and the genes related to bone density have been implicated in disease pathogenesis. CONCLUSION This review shows that occupational factors were extensively studied in knee OA unlike OA of other anatomical regions. Although genetic association studies performed to date identified a number of risk variants, some of these associations have not been consistently replicated across different studies and populations. Therefore, more research is needed.

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Common variations in estrogen-related genes are associated with severe large-joint osteoarthritis: a multicenter genetic and functional study

Abstract: Common genetic variations of the aromatase and ER genes are associated with the risk of severe OA of the large joints of the lower limb in a sex-specific manner. These results are consistent with the hypothesis that estrogen activity may influence the development of large-joint OA.

Cited by 35 publications

References 43 publications

The Genetics of Osteoarthritis

The Genetics of Osteoarthritis

Examining sex differences in knee pain: the Multicenter Osteoarthritis Study

Occupational and genetic risk factors for osteoarthritis: A review

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