Common variants of xeroderma pigmentosum genes and prostate cancer risk

Mirecka, A.; Paszkowska-Szczur, Katarzyna; Scott, Rodney J.; Górski, Bohdan; Wetering, Thierry van de; Wokołorczyk, Dominika; Gromowski, Tomasz; Serrano-Fernández, Pablo; Cybulski, Cezary; Kashyap, Aniruddh; Gupta, Satish; Gołąb, Adam; Słojewski, Marcin; Sikorski, Andrzej; Lubiński, Jan; Dębniak, Tadeusz

doi:10.1016/j.gene.2014.06.026

Cited by 21 publications

(20 citation statements)

References 38 publications

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“…The final meta-analysis included 47 articles. There were 22 articles with 12,833 cases and 151,86 controls for rs1047768 T>C [7–9, 12, 14–31], 14 studies with 11,327 cases and 12,684 controls for rs2296147 T>C [9–11, 13, 18, 24, 26–28, 32–37], 11 studies with 5,898 cases and 7,448 controls for rs2227869 G>C [8, 9, 14, 17, 18, 20, 22, 25, 38–40], 17 studies with 9,826 cases and 10,552 controls for rs2094258 C>T [10, 11, 18, 24, 26–28, 34–37, 41–46], 21 studies with 10,369 cases and 11,207 controls for rs751402 C>T [10, 13, 24, 26–29, 31, 32, 36, 37, 42–45, 47–52], and 14 studies with 10,873 cases and 12,535 controls for rs873601 G>A [9–11, 18, 24, 26–28, 32, 34, 36, 52–54]. A flow chart summarizing the process of relevant study identification is shown in Figure 1, and the study characteristics are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

XPGgene polymorphisms and cancer susceptibility: evidence from 47 studies

et al. 2017

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Xeroderma pigmentosum group G (XPG) is a single-strand-specific DNA endonuclease that functions in the nucleotide excision repair pathway. Genetic variations in XPG gene can alter the DNA repair capacity of this enzyme. We evaluated the associations between six single nucleotide polymorphisms (SNPs) in XPG (rs1047768 T>C, rs2296147 T>C, rs2227869 G>C, rs2094258 C>T, rs751402 C>T, and rs873601 G>A) and cancer risk. Forty-seven studies were identified in searches of the PubMed, Scopus, Web of Science, China National Knowledge Infrastructure, and WanFang databases. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a fixed or random effects model. We found that rs873601 G>A was associated with an increased overall cancer risk (AA vs. GG: OR = 1.14, 95% CI = 1.06–1.24; GA/AA vs. GG: OR = 1.08, 95% CI = 1.02–1.15; A vs. G: OR = 1.06, 95% CI = 1.02–1.10). In a stratified analysis, rs1047768 T>C was associated with an increased risk of lung cancer, rs2227869 G>C was associated with a decreased risk of cancer in population-based studies, and rs751402 C>T and rs873601 G>A were associated with the risk of gastric cancer. Our data indicate that rs873601 G>A is associated with cancer susceptibility.

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Section: Resultsmentioning

confidence: 99%

XPGgene polymorphisms and cancer susceptibility: evidence from 47 studies

et al. 2017

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“…For example, Mirecka et al investigated 15 SNPs in seven XP genes ( XPA-XPG ) in a case-control study of 720 PCa patients and 1,121 cancer-free controls, and they found an increased risk of PCa was associated with the XPD SNP, rs1799793 (Asp312Asn) AG and AA genotypes [25]. In another study conducted by Hooker S et al, the homozygous variant genotype of XPG/ERCC5 -72C/T promoter polymorphism was found to be associated with a significantly decreased risk of PCa [26].…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations

Wang

et al. 2016

Oncotarget

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Genetic variants of nucleotide excision repair (NER) genes have been extensively investigated for their roles in the development of prostate cancer (PCa); however, the published results have been inconsistent. In a hospital-based case-control study of 1,004 PCa cases and 1,055 cancer-free controls, we genotyped eight potentially functional single nucleotide polymorphisms (SNPs) of NER genes (i.e., XPC, rs2228001 T>G and rs1870134 G>C; XPD, rs13181 T>G and rs238406 G>T; XPG, rs1047768 T>C, rs751402 C>T, and rs17655 G>C; and XPF, rs2276464 G>C) and assessed their associations with risk of PCa by using logistic regression analysis. Among these eight SNPs investigated, only XPC rs1870134 CG/CC variant genotypes were associated with a decreased risk of prostate cancer under a dominant genetic model (adjusted odds ratio [OR] = 0.77, 95% confidence interval [CI] = 0.64–1.91, P = 0.003). Phenotype-genotype analysis also suggested that the XPC rs1870134 CG/CC variant genotypes were associated with significantly decreased expression levels of XPC mRNA in a mix population of different ethnicities. These findings suggested that XPC SNPs may contribute to risk of PCa in Eastern Chinese men.

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“…Previous studies have reported that XPG gene polymorphisms are associated with different kinds of cancers (Liu et al, 2014;Mirecka et al, 2014;Steck et al, 2014;Xu et al, 2014;Paszkowska-Szczur et al, 2015). In this paper, we conducted a casecontrol study to investigate the role of three common single nucleotide polymorphisms (SNPs) in the XPG gene (rs2094258, rs751402 and rs17655) in the development of gastric cancer in a Chinese population.…”

Section: Introductionmentioning

confidence: 99%

Association between XPG gene polymorphisms and development of gastric cancer risk in a Chinese population

Dq²,

J³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms (SNPs) in the xeroderma pigmentosum complementation group G (XPG) gene (rs2094258, rs751402 and rs17655) in the development of gastric cancer in a Chinese population. Between January 2012 and December 2014, samples from a total of 177 patients with gastric cancer and 237 control subjects were collected from the Ankang City Central Hospital. XPG rs2094258, rs751402 and rs17655 polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism. Using logistic regression analysis, we found that the CC genotype of rs17655 was associated with an elevated risk of gastric cancer, and the adjusted odds ratio (OR) and 95% confidence intervals (95%CI) were 1.91 and 1.07-3.41, respectively. Moreover, individuals carrying the GC + CC genotype of rs17655 had an increased susceptibility to gastric cancer (OR = 1.61, 95%CI = 1.03-2.54). However, we did not observe a significant association between XPG rs2094258 and rs751402 polymorphisms and development of gastric cancer. In conclusion, our study suggests that the rs17655 polymorphism in XPG is associated with an increased risk of gastric cancer. The results of our findings should be further validated by further large sample size studies.

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Common variants of xeroderma pigmentosum genes and prostate cancer risk

Cited by 21 publications

References 38 publications

XPGgene polymorphisms and cancer susceptibility: evidence from 47 studies

XPGgene polymorphisms and cancer susceptibility: evidence from 47 studies

Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations

Association between XPG gene polymorphisms and development of gastric cancer risk in a Chinese population

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