Common Variant in Glycoprotein Ia Increases Long‐Term Adverse Events Risk After Coronary Artery Bypass Graft Surgery

Abstract

BackgroundThis study was aimed to investigate the clinical relevance between glycoprotein Ia (GPIA) rs1126643C/T polymorphism and the outcome of coronary artery disease after coronary artery bypass graft (CABG) surgery and explore the involved potential mechanisms.Methods and ResultsWe genotyped GPIA rs1126643 polymorphism of 1592 patients who underwent CABG and followed up for a median period of 72.8 months. Patients who are GPIA rs1126643 T‐allele carriers have a higher major adverse cardiac or cerebrovascular events risk post‐CABG than those who are CC homozygotes (hazard ratio [HR]=1.29; P=0.022). The clinical association between the risk allele (T) carriage and major adverse cardiac or cerebrovascular events was confirmed in another cohort study, which included 646 CABG patients from various health centers across China. Meanwhile, rs1126643 T allele was also linked with increased risk of major adverse cardiac or cerebrovascular events (HR=1.73; P=0.019). To explore the underlying mechanisms, we prospectively recruited 131 coronary artery disease patients, assessed their platelet aggregation function, and focused on detecting their GPIA mRNA level and protein expression. Results showed that patients with rs1126643 T allele have elevated platelet aggregation activity (P=0.029) when protein expression is increased (P<0.001) and not affected by glycoprotein Ia mRNA level.ConclusionsThe synonymous common variant, GPIA rs1126643, increases the long‐term adverse events risk of CABG by augmenting GPIa protein expression and enhancing platelet aggregation function. This finding can serve as the implication of improving secondary prevention of CABG patients.

The metabolic score for insulin resistance in the prediction of major adverse cardiovascular events in patients after coronary artery bypass surgery: a multicenter retrospective cohort study

“…Preventing recurrent cardiovascular events in patients who underwent CABG is a signi cant challenge [22]. The previous study reported that the incidence of 5-year MACE in individuals with post-CABG is around 11.8% to 31.0% [23], indicating early identi cation of patients prone to MACE after having CABG is essential. However, most previous studies focused on the effect of traditional risk factors.…”

The metabolic score for insulin resistance in the prediction of major adverse cardiovascular events in patients after coronary artery bypass surgery: a multicenter retrospective cohort study

“…Preventing recurrent cardiovascular events in patients who underwent CABG is a significant challenge [ 24 ]. The previous study reported that the incidence of 5-year MACE in individuals with post-CABG is around 11.8 to 31.0% [ 25 ], indicating that early identification of patients prone to MACE after having CABG is essential. However, most previous studies focused on the effect of traditional risk factors [ 6 , 7 ].…”

GPla Polymorphisms Are Associated with Outcomes in Patients at High Cardiovascular Risk

“…The patient collective in this study suffered to a large extent of 3-vessel disease (88%) and several cardiovascular risk factors (hypertension 67%, hyperlipidemia 68%, and diabetes mellitus 33%), which predestines them for future cardiovascular events. Patients with hypertension showed a significantly increased rate of major adverse cardiovascular events when compared to patients without hypertension ( 29 ). Heeschen et al have previously shown that elevated levels of soluble CD40 ligand (sCD40L), which is released after platelet activation, are associated with increased risk of cardiovascular events in patients with CAD ( 30 ).…”