Common variable immunodeficiency syndrome in an adult

Lourdes, Laura S.; Daily, Karen

doi:10.1016/s0140-6736(14)60415-3

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…It is defined by low amounts of IgG and IgA or IgM, corresponding to a lack of proper seroconversion and insufficient response to polysaccharide vaccines without other causes for hypogammaglobulinemia [ 110 ]. Only a few cases have linked CVID to HSE or other severe manifestation of HSV infection, and the association remains weak [ 95 , 111 ].…”

Section: Inborn Errors Of Lymphocyte Functionmentioning

confidence: 99%

Inborn Errors of Immunity Predisposing to Herpes Simplex Virus Infections of the Central Nervous System

2023

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Herpesvirus infections can lead to a number of severe clinical manifestations, particularly when involving the central nervous system (CNS), causing encephalitis and meningitis. However, understanding of the host factors conferring increased susceptibility to these diseases and their complications remains incomplete. Previous studies have uncovered defects in the innate Toll-like receptor 3 pathway and production of type I interferon (IFN-I) in children and adults that predispose them to herpes simplex encephalitis. More recently, there is accumulating evidence for an important role of IFN-independent cell-autonomous intrinsic mechanisms, including small nucleolar RNAs, RNA lariat metabolism, and autophagy, in restricting herpesvirus replication and conferring protection against CNS infection. The present review first describes clinical manifestations of HSV infection with a focus on neurological complications and then summarizes the host–pathogen interactions and innate immune pathways responsible for sensing herpesviruses and triggering antiviral responses and immunity. Next, we review the current landscape of inborn errors of immunity and the underlying genetic defects and disturbances of cellular immune pathways that confer increased susceptibility to HSV infection in CNS. Ultimately, we discuss some of the present outstanding unanswered questions relating to inborn errors of immunity and HSV CNS infection together with some perspectives and future directions for research in the pathogenesis of these severe diseases in humans.

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Section: Inborn Errors Of Lymphocyte Functionmentioning

confidence: 99%

Inborn Errors of Immunity Predisposing to Herpes Simplex Virus Infections of the Central Nervous System

2023

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“…Be particularly careful if you are not accustomed to SI units but are converting to them for the purpose of publication. Thus it is incorrect to say that a patient's blood count showed a ‘raised white blood cell count of 1·3 × 10⁹/l’ (Lourdes & Daily, ). Similarly, a patient does not have ‘thrombocytosis (platelets 71·0 × 10 9 /l)’ (Falcini et al , ).…”

Section: Writing a Scientific Articlementioning

confidence: 99%

The finer points of writing and refereeing scientific articles

2016

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Writing scientific papers is a skill required by all haematologists. Many also need to be able to referee papers submitted to journals. These skills are not often formally taught and as a result may not be done well. We have reviewed published evidence of errors in these processes. Such errors may be ethical, scientific or linguistic, or may result from a lack of understanding of the processes. The objective of the review is, by highlighting errors, to help writers and referees to avoid them.

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Common variable immunodeficiency syndrome in an adult

Cited by 2 publications

References 5 publications

Inborn Errors of Immunity Predisposing to Herpes Simplex Virus Infections of the Central Nervous System

Inborn Errors of Immunity Predisposing to Herpes Simplex Virus Infections of the Central Nervous System

The finer points of writing and refereeing scientific articles

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