Common variable immunodeficiency—an independent risk factor for atherosclerotic cardiovascular diseases
Juho Mattila,
Niina Pitkänen,
Hannu Järveläinen
Abstract:Atherosclerosis, a disease of chronic inflammation of the arterial wall, is the main cause of most cardiovascular diseases (CVDs). Common variable immunodeficiency (CVID), a group of diseases characterized by frequent infections due to defective antibody production and lack of human immunoglobulins, plays a role in immune activation and inflammation. Thus, it can be hypothesized that CVID increases the risk for atherosclerotic CVDs. On the other hand, it is also possible that CVID patients are protected from a… Show more
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