2019
DOI: 10.1186/s13227-019-0124-7
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Common themes in tetrapod appendage regeneration: a cellular perspective

Abstract: Complete and perfect regeneration of appendages is a process that has fascinated and perplexed biologists for centuries. Some tetrapods possess amazing regenerative abilities, but the regenerative abilities of others are exceedingly limited. The reasons underlying these differences have largely remained mysterious. A great deal has been learned about the morphological events that accompany successful appendage regeneration, and a handful of experimental manipulations can be reliably applied to block the proces… Show more

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Cited by 13 publications
(6 citation statements)
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“…Copyright 2011, American Association for Anatomy. (F,G) Reproduced with permission . Copyright 2019, Springer Nature.…”
Section: Bioelectric Flatworms: Permanent But Stochastic Re‐writing Omentioning
confidence: 99%
“…Copyright 2011, American Association for Anatomy. (F,G) Reproduced with permission . Copyright 2019, Springer Nature.…”
Section: Bioelectric Flatworms: Permanent But Stochastic Re‐writing Omentioning
confidence: 99%
“…The simultaneous regeneration of multiple tissues is a complex process and requires the presence of different cell phenotypes that are able to maintain their relative physiological functions and phenotypic characteristics within one complex and heterogeneous environment to enable the regeneration of the distinct multi-tissue units 3,4 . However, one of the current major challenges during the regeneration of multiple tissues is the ability to maintain the physiological functions and phenotypic characteristics of distinct types of cells in one milieu.…”
Section: Robust Phenotypic Maintenance Of Limb Cells During Heterogenmentioning
confidence: 99%
“…Contemporary vertebrate appendage regeneration models follow a similar order of events: epithelial closure of the wound site, establishment of a wound epithelium, dedifferentiation or activation of cells leading to epimorphic blastema formation, and proliferation and redifferentiation of progenitor cells to regenerate various appendage cell types in a lineage‐restricted manner (or what appears to be lineage‐restricted in species thoroughly investigated thus far) 12 . The model is not all‐encompassing: morphologically simpler vertebrates can fully regenerate appendages, while more complex vertebrates generally possess extremely limited appendage regeneration.…”
Section: Introduction To Regeneration In the Animal Kingdommentioning
confidence: 99%