Common SNPs of <i>AmelogeninX (AMELX)</i> and Dental Caries Susceptibility

Gasse, Barbara; Grabar, Sophie; Lafont, Anne Gaëlle; Quinquis, Laurent; Vital, Sibylle; Davit-Béal, Tiphaine; Moulis, Estelle; Chabadel, Olivier; Hennequin, Martine; Courson, Frédéric; Droz, Dominique; Vaysse, F.; Laboux, O.; Tassery, Hervé; Al-Hashimi, Nawfal; Boillot, A; Carel, Jean Claude; Tréluyer, Jean‐Marc; Jeanpierre, Marc; Beldjord, Chérif; Sire, Jean‐Yves; Miller, Catherine

doi:10.1177/0022034513482941

Cited by 33 publications

(32 citation statements)

References 22 publications

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“…5 There were also no associations between amelogenin genetic variants and dental caries experience in other studies performed on Polish, French, Caucasian, and Japanese populations. [6][7][8]12 However, studied SNPs for AMELX gene and the age of children were different from those chosen for our study, also the studied populations were heterogeneous regarding demographic origins and cultural diversity.…”

Section: Discussionmentioning

confidence: 90%

“…1,[4][5][6][7][8][9][10][11][12] The present study is limited to Polish Caucasian children and, to the best of our knowledge, our study is the first one concerning the genetic aspect of dental caries to be performed on such a homogenous population in Poland. It is well established that multiple environmental as well as genetic factors contribute to caries.…”

Section: Discussionmentioning

confidence: 99%

“…Literature data describes possible association between the genes responsible for production of different enamel proteins and dental caries occurrence. 1,[4][5][6][7][8][9][10][11][12][13] Mature tooth enamel consists almost completely of inorganic material (above 90%). However, during the development it is composed of organic matrix, which is mostly replaced by mineral compounds.…”

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confidence: 99%

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Chosen single nucleotide polymorphisms (SNPs) of enamel formation genes and dental caries in a population of Polish children

Gerreth¹,

Zaorska²,

Zabel³

et al. 2017

Adv Clin Exp Med

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The authors thank the children who participated in the study for agreement and cooperation, their parents for the informed consent and the staff of the day nurseries for help in carrying out the patients' examination. AbstractBackground. It is increasingly emphasized that the influence of a host's factors in the etiology of dental caries are of most interest, particularly those concerned with genetic aspect.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Chosen single nucleotide polymorphisms (SNPs) of enamel formation genes and dental caries in a population of Polish children

Gerreth¹,

Zaorska²,

Zabel³

et al. 2017

Adv Clin Exp Med

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“…Genetic characteristics of the host were shown to influence dental hard tissue properties [Gasse et al, 2013], as well as saliva [Ozturk et al, 2010] and immune system [de Soet et al, 2008] and even the behavior of the individual, e.g. taste preference [Wendell et al, 2010].…”

Section: Healthy Oral Ecosystemmentioning

confidence: 99%

Towards Understanding Oral Health

Zaura

Cate

2015

Caries Res

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During the last century, dental research has focused on unraveling the mechanisms behind various oral pathologies, while oral health was typically described as the mere absence of oral diseases. The term ‘oral microbial homeostasis' is used to describe the capacity of the oral ecosystem to maintain microbial community stability in health. However, the oral ecosystem itself is not stable: throughout life an individual undergoes multiple physiological changes while progressing through infancy, childhood, adolescence, adulthood and old age. Recent discussions on the definition of general health have led to the proposal that health is the ability of the individual to adapt to physiological changes, a condition known as allostasis. In this paper the allostasis principle is applied to the oral ecosystem. The multidimensionality of the host factors contributing to allostasis in the oral cavity is illustrated with an example on changes occurring in puberty. The complex phenomenon of oral health and the processes that prevent the ecosystem from collapsing during allostatic changes in the entire body are far from being understood. As yet individual components (e.g. hard tissues, microbiome, saliva, host response) have been investigated, while only by consolidating these and assessing their multidimensional interactions should we be able to obtain a comprehensive understanding of the ecosystem, which in turn could serve to develop rational schemes to maintain health. Adapting such a ‘system approach' comes with major practical challenges for the entire research field and will require vast resources and large-scale multidisciplinary collaborations.

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“…Polymorphisms in the LTF gene were reported to be associated with herpes simplex keratitis [Keijser et al, 2008], aggressive periodontitis , and caries [Azevedo et al, 2010]. However, there are few studies investigating the association of polymorphisms in salivary protein genes with caries susceptibility [Jonasson et al, 2007;Peres et al, 2010;Schlafer et al, 2012;Gasse et al, 2013;Krasone et al, 2014].…”

Section: Introductionmentioning

confidence: 99%

Lactotransferrin Gene Polymorphism Associated with Caries Experience

et al. 2015

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Dental caries is a common multifactorial disease, resulting from the interaction of biofilm, cariogenic diet and host response over time. Lactotransferrin (LTF) is a main salivary glycoprotein, which modulates the host immune-inflammatory and antibacterial response. Although a genetic component for caries outcome has been identified, little is known over the genetic aspects underlying its susceptibility. Thus, the aim of this study was to investigate the association between LTF polymorphisms and caries susceptibility. Six hundred seventy seven 12-year-old students were selected: 346 with (DMFT ≥ 1) and 331 without caries experience (DMFT = 0). Also, individuals concentrating higher levels of disease (polarization group, DMFT ≥ 2, n = 253) were tested against those with DMFT ≤ 1 (n = 424). Along with clinical parameters, three representative LTF tag SNPs (rs6441989, rs2073495, rs11716497) were genotyped and the results were evaluated using univariate and multivariate analyses. Allele A for tag SNP rs6441989 was found to be significantly less frequent in the polarization group, conferring a protective effect against caries experience [AA + AG × GG (OR: 0.710, 95% CI: 0.514-0.980, p = 0.045)], and remained significantly associated with caries protection in the presence of gingivitis (p = 0.020) and plaque (p = 0.035). These results might contribute to the understanding of the genetic control of caries susceptibility in humans.

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Common SNPs of AmelogeninX (AMELX) and Dental Caries Susceptibility

Cited by 33 publications

References 22 publications

Chosen single nucleotide polymorphisms (SNPs) of enamel formation genes and dental caries in a population of Polish children

Chosen single nucleotide polymorphisms (SNPs) of enamel formation genes and dental caries in a population of Polish children

Towards Understanding Oral Health

Lactotransferrin Gene Polymorphism Associated with Caries Experience

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