Common single nucleotide polymorphisms in the FNDC5 gene and serum irisin levels in acute myocardial infarction

Etem, Ebru Önalan; Diş, Özge; Tektemur, Ahmet; Korkmaz, Hasan; Kavuran, İlay Buran

doi:10.5152/anatoljcardiol.2021.36214

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…To complement the assessment of irisin at the protein level, we also assessed whether the observed differences resulted from genetic variability. Although previous research has reported contradictory findings on this association [29], irisin polymorphisms have been associated with obesity and related comorbidities [30]. The rs3480 noncoding polymorphism of FNDC5 is of interest here, given its association with blood pressure and lipid profiles [31].…”

Section: Discussionmentioning

confidence: 93%

Irisin as a Novel Biomarker of Subclinical Atherosclerosis in Severe Obesity

Carmona-Maurici

Rosa

Azcona-Granada

et al. 2023

IJMS

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Severe obesity (SO) can accelerate atherosclerosis and the onset of acute cardiovascular events. The diagnosis of atherosclerosis in the context of a high body mass index (BMI) can be challenging, making the identification of biomarkers clinically relevant. We aimed to assess the usefulness of irisin as a biomarker for subclinical atherosclerosis in participants with SO. This prospective observational study included 61 participants undergoing bariatric surgery for SO, defined as a BMI >40 kg/m2 or >35 kg/m2 with at least one comorbidity. Atherosclerotic plaques were detected by ultrasound. Plasma samples were obtained 1 month before and at 6 and 12 months after bariatric surgery to measure irisin by ELISA. Additionally, subcutaneous samples of adipose tissue were taken and genotyped to identify irisin polymorphism rs3480. Irisin levels were positively correlated with BMI (r = 0.23, p = 0.0064), negatively correlated with atheroma-related parameters (e.g., carotid intima-media thickness), and lower in subjects with atheroma (p < 0.0002). Irisin also showed good overall accuracy for discriminating plaque presence (AUC, 0.81; 95% CI, 0.6956–0.9156). However, the rs3480 polymorphism correlated with neither the irisin levels nor the presence of atheromas. Iirisin could identify subclinical atherosclerosis in SO and might facilitate clinical diagnosis.

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Section: Discussionmentioning

confidence: 93%

Irisin as a Novel Biomarker of Subclinical Atherosclerosis in Severe Obesity

Carmona-Maurici

Rosa

Azcona-Granada

et al. 2023

IJMS

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“…Fourth, the combination of radiomics characteristics and genomic data is described as radiogenomics (11). Gene regulation plays an important role in the occurrence of MI and cardiac remodeling after MI (72,73). In the future, combinations of TA features and genomic data may have potential clinical application value in MI.…”

Section: Prospectsmentioning

confidence: 99%

Magnetic Resonance Texture Analysis in Myocardial Infarction

Peng

Zheng

Tang

et al. 2021

Front. Cardiovasc. Med.

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Texture analysis (TA) is a newly arisen field that can detect the invisible MRI signal changes among image pixels. Myocardial infarction (MI) is cardiomyocyte necrosis caused by myocardial ischemia and hypoxia, becoming the primary cause of death and disability worldwide. In recent years, various TA studies have been performed in patients with MI and show a good clinical application prospect. This review briefly presents the main pathogenesis and pathophysiology of MI, introduces the overview and workflow of TA, and summarizes multiple magnetic resonance TA (MRTA) clinical applications in MI. We also discuss the facing challenges currently for clinical utilization and propose the prospect.

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“… 7 Irisin is encoded by the fibronectin type III domain containing protein 5 ( FNDC 5) gene. 8 , 9 As a precursor of irisin, FNDC5 is highly expressed in the heart, brain, liver and skeletal muscle, and is essential for maintaining metabolic homeostasis. 10 , 11 It has been reported that the levels of FNDC5 mRNA in adipose tissue and circulating irisin negatively correlated with hyperglycaemia, triglycerides, visceral adiposity and extramyocellular lipid deposition.…”

Section: Introductionmentioning

confidence: 99%

An Association Between FNDC5, PGC-1α Genetic Variants and Obesity in Chinese Children: A Case-Control Study

Wang¹,

Zhang²,

Wu³

et al. 2023

DMSO

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Background Fibronectin type III domain containing protein 5 ( FNDC5 ) gene encodes irisin that regulates adipose tissue metabolism. Peroxide-proliferator-activated receptor γ coactivator 1α ( PGC-1α ) is a powerful promoter of mitochondrial biosynthesis and oxidative metabolism, which plays an important role in inducing heat production and energy consumption of brown fat. PGC1-α expression stimulated an increase in expression of FNDC5 . Purpose The aims of this study were to analyze the association between FNDC5, PGC-1α genetic variants and overweight or obesity in Chinese children and adolescents. Methods A total of 198 children and adolescents with overweight or obesity and 198 children and adolescents with normal weight were screened according to gender and age 1:1. The healthy eating behaviors, moderate-to-vigorous physical activity time were surveyed using food frequency questionnaire and CLASS questionnaire, respectively. Genotypes of FNDC5 and PGC-1α gene were detected using SNaPshot method. Results GT genotype of FNDC 5 (rs16835198) increased the risk of overweight or obesity in boys (OR (95% CI): 1.68 (1.00, 2.93)) based on overdominant model; GG genotype of FNDC 5 (rs16835198) decreased the risk of overweight or obesity in girls and boys (OR (95% CI): 0.45 (0.21,0.97), 0.45 (0.24, 0.83), respectively) based on dominant model; TT genotype of FNDC 5 (rs16835198) increased the risk of overweight or obesity in girls based on recessive model (OR (95% CI): 2.46 (1.19, 5.05)), and based on the additive model (OR (95% CI): 3.82 (1.49, 9.80)). There was significant interaction between FNDC 5 (rs16835198) and PGC -1α (rs3755863, rs8192678), healthy eating behaviors, moderate-to-vigorous physical activity time, interaction between PGC-1α (rs8192678) and moderate-to-vigorous physical activity time in the occurrence of overweight or obesity in Chinese children and adolescents. Conclusion FNDC5 (rs16835198) played an independent or interactive role with PGC -1α (rs3755863, rs8192678), healthy eating behaviors, moderate-to-vigorous physical activity time in the occurrence of overweight or obesity in Chinese children and adolescents.

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Common single nucleotide polymorphisms in the FNDC5 gene and serum irisin levels in acute myocardial infarction

Cited by 3 publications

References 36 publications

Irisin as a Novel Biomarker of Subclinical Atherosclerosis in Severe Obesity

Irisin as a Novel Biomarker of Subclinical Atherosclerosis in Severe Obesity

Magnetic Resonance Texture Analysis in Myocardial Infarction

An Association Between FNDC5, PGC-1α Genetic Variants and Obesity in Chinese Children: A Case-Control Study

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