Common single nucleotide polymorphisms in the FNDC5 gene are associated with glucose metabolism but do not affect serum irisin levels in Japanese men with low fitness levels

Tanisawa, Kumpei; Taniguchi, Hirokazu; Sun, Xiaomin; Ito, Tomoko; Cao, Zhen-Bo; Sakamoto, Shizuo; Higuchi, Mitsuru

doi:10.1016/j.metabol.2014.01.005

Cited by 47 publications

(46 citation statements)

References 23 publications

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“…Here, we failed to detect any significant association between the two FNDC5 SNPs we studied and EL, suggesting that other factors (e.g., maybe physical activity levels throughout lifespan, nutritional habits or complex gene-environment associations that are yet to be determined) might have a stronger influence on irisinemia, despite the potential functional consequence of at least one of the two SNPs we studied (i.e., rs726344). In fact, we found no FNDC5 genotype effect on the irisin levels of the Italian cohort, which is in line with recent data on the rs16835198 SNP and serum irisin in Japanese men aged 21-79 years) (Tanisawa et al 2014). On the other hand, the role of epigenetic factors in irisinemia remains to be determined.…”

Section: Discussionsupporting

confidence: 90%

FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs

Sanchís-Gomar

Garatachea

et al. 2014

AGE

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Irisin might play an important role in reducing the risk of obesity, insulin resistance, or several related diseases, and high irisin levels may contribute to successful aging. Thus, the irisin precursor (FNDC5) gene is a candidate to influence exceptional longevity (EL), i.e., being a centenarian. It has been recently shown that two single-nucleotide polymorphisms (SNPs) in the FNDC5 gene, rs16835198 and rs726344, are associated with in vivo insulin sensitivity in adults. We determined luciferase gene reporter AGE (2014) 36:9733 DOI 10.1007 Fabian Sanchis-Gomar and Nuria Garatachea contributed equally to this paper activity in the two above-mentioned SNPs and studied genotype distributions among centenarians (n=175, 144 women) and healthy controls (n=347, 142 women) from Spain. We also studied an Italian [79 healthy centenarians (40 women) and 316 healthy controls (156 women)] and a Japanese cohort [742 centenarians (623 women) and 499 healthy controls (356 women)]. The rs726344 SNP had functional significance, as shown by differences in luciferase activity between the constructs of this SNP (all P≤0.05), with the variant A-allele having higher luciferase activity compared with the G-allele (P = 0.04). For the rs16835198 SNP, the variant T-allele tended to show higher luciferase activity compared with the G-allele (P=0.07). However, we found no differences between genotype/allele frequencies of the two SNPs in centenarians versus controls in any cohort, and no significant association (using logistic regression adjusted by sex) between the two SNPs and EL. Further research is needed with different cohorts as well as with additional variants in the FNDC5 gene or in other genes involved in irisin signaling.

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Section: Discussionsupporting

confidence: 90%

FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs

Sanchís-Gomar

Garatachea

et al. 2014

AGE

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“…However, there are discrepancies regarding the relation of irisin especially with obesity and T2DM. In some studies, a positive association was detected between irisin levels and BMI (24,25,26), while others reported null (27,28).In agreement with Tanisawa et al (29) showed that the Gallele of rs3480 was associated with increased insulin resistance and its complications. In contrast to our results, Nasser M et al ., (30) reported that The rs3480 GG associates with decreased risk of obesity (p = 0.005; odds ratio: 0.48) and lower body mass index (BMI).while rs1746661 variant is associated with elevated triglycerides.…”

Section: Discussionsupporting

confidence: 58%

“…Furthermore, our study showed that Patients with GG genotype showed higher levels of TC, TG, LDL-c and BMI, while HDL-c was higher in patients with AA genotype. Staiger et al, (33) and Tanisawa et al, (29) did not detect any association between rs3480 and HDL-C. However, Tang et al, (34) have reported that rs3480 has a trend towards association with HDL-C and LDL-C levels in overweight subjects.…”

Section: Discussionmentioning

confidence: 93%

Irisin Gene Polymorphism Rs3480 and Rs1746661and Obesity in Egyptian Populations

Allah¹,

Gayed²,

Hammoudah³

et al. 2017

IOSR JBB

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and genotyping of rs3480 (A/G) and rs1746661 (G/T) gene polymorphisms. There was a significant statistical difference between the two groups regarding genotype frequency of FNDC5 (Irisin precursor) rs3480 (A/G) and rs 174661 (G/T). Regarding rs3480 (A/G), there was a high frequency of AA genotype and A allele among the control group, while GG genotype and G allele had the highest frequency among obese group. Regarding rs1746661 (G/T), there was a high frequency of GG genotype and G allele among the control group, while TT genotype and T allele had the highest frequency among obese group. Multivariate logistic regression for risk of obesity showed that the most common risk factor is

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“…Tanisawa (2014) [28] Humans; cross-sectional Association between FNDC5 SNPs, serum irisin, cardiorespiratory fitness and glucose metabolism in men.…”

Section: Study Aim Main Findingsmentioning

confidence: 99%

“…Tanisawa et al [28] studied also rs3480 SNP, as well as rs16835198 in relation to cardiorespiratory fitness and glucose metabolism. Although neither SNP was associated with indices of cardiorespiratory fitness or physical activity, carriers of G allele of rs3480 had higher insulin levels and insulin resistance.…”

Section: Study Aim Main Findingsmentioning

confidence: 99%

Irisin: A true, circulating hormone

2015

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Common single nucleotide polymorphisms in the FNDC5 gene are associated with glucose metabolism but do not affect serum irisin levels in Japanese men with low fitness levels

Cited by 47 publications

References 23 publications

FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs

FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs

Irisin Gene Polymorphism Rs3480 and Rs1746661and Obesity in Egyptian Populations

Irisin: A true, circulating hormone

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