Common Programming Strategies for Deep Brain Stimulation

Salinas, Meagen

doi:10.1093/med/9780190647209.003.0001

Cited by 2 publications

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“…Current rTMS treatments are efficacious in approximately 30% of patients which is in line with our results. Further work comparing DBS programming strategies in bigger data sets [64] and electrical field modelling [65,66] is needed to improve the interpretability of the results and reduce the wide interindividual differences regarding the ideal stimulation site relative to the cortex.…”

Section: Discussionmentioning

confidence: 99%

Enhancing neuronal plasticity through intracranial theta burst stimulation in the human sensorimotor cortex

Herrero

Smith

Mishra

et al. 2021

Preprint

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The progress of therapeutic neuromodulation greatly depends on improving stimulation parameters to most efficiently induce neuroplasticity effects. Intermittent Theta Burst stimulation (iTBS), a form of electrical stimulation that mimics the natural brain activity patterns, has shown efficacy in inducing such effects in animal studies and rhythmic Transcranial Magnetic Stimulation (rTMS) studies in humans. However, little is known about the potential neuroplasticity effects of iTBS applied through intracranial electrodes in humans which could have implications for deep brain stimulation therapies. This study characterizes the physiological effects of cortical iTBS in the human cortex and compare them with single pulse alpha stimulation, another frequently used paradigm in rTMS research. We applied these stimulation paradigms to well-defined regions in the sensorimotor cortex which elicited contralateral hand or arm muscle contractions during electrical stimulation mapping in epilepsy patients implanted with intracranial electrodes. Treatment effects were evaluated using effective connectivity and beta oscillations coherence measures in areas connected to the treatment site as defined with cortico-cortical evoked potentials. Our results show that iTBS increases beta band synchronization within the sensorimotor network indicating a potential neuroplasticity effect. The effect is specific to the sensorimotor system, the beta frequency band and the stimulation pattern (no effect was found with single-pulse alpha stimulation). The effects outlasted the stimulation by three minutes. By characterizing the neurophysiological effects of iTBS within well-defined cortical networks, we hope to provide an electrophysiological framework that allows clinicians and researchers to optimize brain stimulation protocols which may have translational value.

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Section: Discussionmentioning

confidence: 99%

Enhancing neuronal plasticity through intracranial theta burst stimulation in the human sensorimotor cortex

Herrero

Smith

Mishra

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Inducing neuroplasticity through intracranial θ-burst stimulation in the human sensorimotor cortex

Herrero

Smith

Mishra

et al. 2021

Journal of Neurophysiology

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The progress of therapeutic neuromodulation greatly depends on improving stimulation parameters to most efficiently induce neuroplasticity effects. Intermittent Theta Burst stimulation (iTBS), a form of electrical stimulation that mimics natural brain activity patterns, has proved to efficiently induce such effects in animal studies and rhythmic Transcranial Magnetic Stimulation studies in humans. However, little is known about the potential neuroplasticity effects of iTBS applied through intracranial electrodes in humans. This study characterizes the physiological effects of intracranial iTBS in humans and compare them with alpha frequency stimulation, another frequently used neuromodulatory pattern. We applied these two stimulation patterns to well-defined regions in the sensorimotor cortex, which elicited contralateral hand muscle contractions during clinical mapping, in epilepsy patients implanted with intracranial electrodes. Treatment effects were evaluated using oscillatory coherence across areas connected to the treatment site, as defined with cortico-cortical evoked potentials. Our results show that iTBS increases coherence in the beta frequency band within the sensorimotor network indicating a potential neuroplasticity effect. The effect is specific to the sensorimotor system, the beta-band and the stimulation pattern, and outlasted the stimulation period by ~3 minutes. The effect occurred in 4/7 subjects depending on the build-up of the effect during iTBS treatment and other patterns of oscillatory activity related to ceiling effects within the beta-band and to pre-existent coherence within the alpha-band. By characterizing the neurophysiological effects of iTBS within well-defined cortical networks, we hope to provide an electrophysiological framework that allows clinicians/researchers to optimize brain stimulation protocols which may have translational value.

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Common Programming Strategies for Deep Brain Stimulation

Cited by 2 publications

References 0 publications

Enhancing neuronal plasticity through intracranial theta burst stimulation in the human sensorimotor cortex

Enhancing neuronal plasticity through intracranial theta burst stimulation in the human sensorimotor cortex

Inducing neuroplasticity through intracranial θ-burst stimulation in the human sensorimotor cortex

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