Common polymorphisms in CYP2C9, subclinical atherosclerosis and risk of ischemic vascular disease in 52 000 individuals

Kaur-Knudsen, Diljit; Bojesen, Stig E.; Nordestgaard, Børge G.

doi:10.1038/tpj.2009.34

Cited by 20 publications

(15 citation statements)

References 26 publications

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“…However, for ischemic heart disease, a decreased risk was detected in a cross-sectional study with a hazard ratio of 0.9 (0.8-1.0), which remained significant after multifactorial adjustment. However, the finding could not be confirmed in a large prospective study or in a large case-control study with enough power to exclude even minor changes of risk with 90% power [78]. The lack of association between CYP2C9 and risk of ischemic vascular disease in this study is in accordance with other studies [79][80][81][82].…”

Section: Cyp2c9 and Risk Of Ischemic Vascular Diseasecontrasting

confidence: 49%

“…Atherosclerosis is a key process in the development of ischemic vascular disease such as ischemic heart disease, myocardial infarction, ischemic cerebrovascular disease and ischemic stroke. Kaur-Knudsen et al [78] found no difference in subclinical atherosclerosis across CYP2C9*2 and CYP2C9*3 genotype when comparing ankle brachial blood pressure index as a marker for peripheral arterial disease, or in plasma concentration of C-reactive protein as a marker of inflammation. Kaur-Knudsen et al also did not detect any change of risk of myocardial infarction, ischemic cerebrovascular disease, or ischemic stroke across CYP2C9 genotype in two large population studies (Fig.…”

Section: Cyp2c9 and Risk Of Ischemic Vascular Diseasementioning

confidence: 98%

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Cytochrome P450 1B1 and 2C9 Genotypes and Risk of Ischemic Vascular Disease, Cancer, and Chronic Obstructive Pulmonary Disease

Kaur-Knudsen

Bojesen²,

Nordestgaard³

2012

CVP

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The aim of this review is to summarize present knowledge of genetic variation in cytochrome P450 1B1 (CYP1B1) and 2C9 (CYP2C9) genes and risk of tobacco-related cancer, female cancer, chronic obstructive pulmonary disease and ischemic vascular disease. The CYP1B1 and CYP2C9 enzymes metabolize polycyclic aromatic hydrocarbons found in tobacco smoke and thereby generate disease-causing metabolites suggested to be important in tobacco-related diseases. Furthermore, CYP1B1 also metabolizes estrogen while CYP2C9 metabolizes arachidonic acid, both creating metabolites potentially important in risk of female cancer or ischemic vascular disease. Genetic variation in genes coding for CYP1B1 and CYP2C9 enzymes have shown altered enzyme activity affecting levels of metabolites and thus potentially risk of disease. So far, however, findings have been inconsistent. Recently, large studies on the association between genetic variation in CYP1B1 and CYP2C9 and risk of disease with considerable statistical power rebutted the hypotheses that these genetic variants affect risk of tobacco-related cancer, female cancer, chronic obstructive pulmonary disease and ischemic vascular disease.

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Section: Cyp2c9 and Risk Of Ischemic Vascular Diseasecontrasting

confidence: 49%

Section: Cyp2c9 and Risk Of Ischemic Vascular Diseasementioning

confidence: 98%

Cytochrome P450 1B1 and 2C9 Genotypes and Risk of Ischemic Vascular Disease, Cancer, and Chronic Obstructive Pulmonary Disease

Kaur-Knudsen

Bojesen²,

Nordestgaard³

2012

CVP

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“…The use of CYP2C9 substrates and inhibitors was associated with a significant increase in the risk of myocardial infarction especially in female harbouring a variant allele (CYP2C8*2, CYP2C9*3) [60]. No association between CYP2C9*2 and CYP2C9*3 polymorphisms and risk of subclinical atherosclerosis, ischemic vascular disease (ischemic heart disease, myocardial infarction, ischemic cerebrovascular disease and ischemic stroke) or cardiovascular death was found in a very large Danish study [61]. Similarly, an association with coronary atherosclerosis, detected by angiography, was found in a small study performed in Turky [62].…”

Section: Cyp2c8 Cyp2c9 Hypertension and Cardiovascular Diseasesmentioning

confidence: 93%

Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?

Fava

Ricci

Melander

et al. 2012

Prostaglandins & Other Lipid Mediators

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“…19 Sex hormones such as estrogens protect against oxidative stress and are known to be vasoprotective. [20][21][22] In recent years, several studies have investigated the association between CYP17A1 heritable variation and CAD. 7,23 However, the relationship between CYP 17A1 genetic polymorphisms and CAD in the Uygur population remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Haplotype analyses of CYP17A1 genetic polymorphisms and coronary artery disease in a Uygur population

Dai

Xie

et al. 2015

J Renin Angiotensin Aldosterone Syst

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Background: The relationship between CYP17A1 genetic polymorphisms and coronary artery disease (CAD) remains unclear. The aim of the present study was to assess the association between CYP17A1 gene polymorphism and CAD in a Chinese Uygur population. Methods: A total of 493 people including 266 patients and 227 controls were selected for the present study. All CAD patients and controls were genotyped for the same five single nucleotide polymorphisms (SNPs) (rs4919686, rs1004467, rs4919687, rs10786712, and rs2486758) by a real-time PCR method. Results: The rs4919686, rs1004467, and rs4919687 polymorphisms were found to be associated with CAD in genotypes, dominant model, recessive model, and allele frequency (rs4919686: all p<0.05, rs1004467: all p≤0.001, rs4919687: all p<0.001); the significant difference was retained (all p<0.05) after adjustment for the major confounding factors. The overall distribution of haplotypes established by SNP1-SNP4 (in total subjects and men) and SNP1-SNP4-SNP5 (in total subjects) were significantly different between the CAD patients and the control subjects (p=0.006, men: p=0.026, and p=0.030, respectively). Conclusion: Polymorphisms rs4919686, rs4919687 and rs1004467 were found to be associated with CAD in this Uygur population.

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Common polymorphisms in CYP2C9, subclinical atherosclerosis and risk of ischemic vascular disease in 52 000 individuals

Cited by 20 publications

References 26 publications

Cytochrome P450 1B1 and 2C9 Genotypes and Risk of Ischemic Vascular Disease, Cancer, and Chronic Obstructive Pulmonary Disease

Cytochrome P450 1B1 and 2C9 Genotypes and Risk of Ischemic Vascular Disease, Cancer, and Chronic Obstructive Pulmonary Disease

Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?

Haplotype analyses of CYP17A1 genetic polymorphisms and coronary artery disease in a Uygur population

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