Common pathomechanism of migraine and depression

Wachowska, Katarzyna; Bliźniewska-Kowalska, Katarzyna; Sławek, Jarosław; Adamczyk-Sowa, Monika; Szulc, Agata; Maes, Michaël; Su, Kuan-Pin; Gałecki, Piotr

doi:10.12740/pp/onlinefirst/143982

Cited by 5 publications

(3 citation statements)

References 51 publications

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“…Many studies have shown that the inflammatory response is an independent factor leading to MDD after AMI [8,9]. The number of monocytes and neutrophils were increased in the blood of AMI patients.…”

Section: Inflammatory Responsementioning

confidence: 99%

Pathophysiological Mechanisms and Pharmaceutical Interventions of Myocardial Infarction with Depression

Xu,

Wei,

Wang

et al. 2023

IJDDP

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Review Pathophysiological Mechanisms and Pharmaceutical Interventions of Myocardial Infarction with Depression Mingyang Xu 1, Yinxiang Wei 2, Zhenhui Wang 1, Yaohui Wang 2, Xiaoming Zhong 3,*, and Qiying Chen 4,* 1 School of medicine, Henan University, Kaifeng 475000, China. 2 Joint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng 475004, China. 3 Department of Cardiology, Huaihe Hospital of Henan University, Kaifeng 475000, China. 4 Department of Cardiology, Huashan Hospital, Fudan University, Shanghai 200040, China. * Correspondence: Xiaoming Zhong (zxm10020202@126.com); Qiying Chen (chenqiying@huashan.org.cn) Received: 23 March 2023 Accepted: 10 May 2023 Abstract: The strong association between acute myocardial infarction (AMI) and major depression disorder（MDD）is a universally accepted. Patients with AMI complicated by MDD often have poor prognosis. Most early studies focused on how AMI leads to MDD, but there are few reports on depression-induced AMI. In terms of mechanism, inflammation, the hypothalamic-pituitary-adrenal axis (HPA axis) and brain-gut axis may be involved in the occurrence and development of MDD after AMI. The inflammatory injury, abnormal sympathetic and vagal nerve activity, HPA axis overactivation, overeating and some therapeutic medicine administration in patients with MDD can also be risk factors for AMI. Both behavioral and pharmaceutical interventions are important for the treatment of AMI with MDD. More drugs are being developed and tested. At present, there are still many issues, needing to be addressed, in the diagnosis, pathogenesis, intervention strategies and therapeutic drugs for AMI with MDD. To aid clinical diagnosis and treatment, this review classifies the existing studies on AMI complicated with MDD, and also includes some of our considerations.

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Section: Inflammatory Responsementioning

confidence: 99%

Pathophysiological Mechanisms and Pharmaceutical Interventions of Myocardial Infarction with Depression

Xu,

Wei,

Wang

et al. 2023

IJDDP

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“…It is responsible for meningeal vasodilation and an increase in vascular permeability, favoring the influx of inflammatory cells that would ultimately lead to the activation of microglia, resulting in a neuroinflammatory process. Similarly, in depression, exposure to chronic stress is commonly linked to chronic inflammation, with a pronounced increase in proinflammatory cytokines crossing the blood-brain barrier (BBB), which, in turn, activates the microglia and induces a neuroinflammatory state [390]. Hence, this section aims to recapitulate the main findings about the inflammatory processes shared by migraine and depression.…”

Section: Immune Systemmentioning

confidence: 99%

Understanding the Biological Relationship between Migraine and Depression

Viudez-Martínez,

Torregrosa,

Navarrete

et al. 2024

Biomolecules

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Migraine is a highly prevalent neurological disorder. Among the risk factors identified, psychiatric comorbidities, such as depression, seem to play an important role in its onset and clinical course. Patients with migraine are 2.5 times more likely to develop a depressive disorder; this risk becomes even higher in patients suffering from chronic migraine or migraine with aura. This relationship is bidirectional, since depression also predicts an earlier/worse onset of migraine, increasing the risk of migraine chronicity and, consequently, requiring a higher healthcare expenditure compared to migraine alone. All these data suggest that migraine and depression may share overlapping biological mechanisms. Herein, this review explores this topic in further detail: firstly, by introducing the common epidemiological and risk factors for this comorbidity; secondly, by focusing on providing the cumulative evidence of common biological aspects, with a particular emphasis on the serotoninergic system, neuropeptides such as calcitonin-gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP), substance P, neuropeptide Y and orexins, sexual hormones, and the immune system; lastly, by remarking on the future challenges required to elucidate the etiopathological mechanisms of migraine and depression and providing updated information regarding new key targets for the pharmacological treatment of these clinical entities.

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“…A study revealed that patients with MDD have a two‐fold risk of migraine compared with non‐MDD individuals (Castelnuovo et al., 2016). The coexistence of migraine and depression constitutes the complexity of treatment, and more research on the comorbid mechanisms appears to be worth considering (Wachowska et al., 2023). There are differences in brain volume among patients with MDD and migraine (Ma et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

Alterations of amygdala volume and functional connectivity in migraine patients comorbid with and without depression

Chen,

Gui,

et al. 2024

Brain and Behavior

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ObjectiveThe comorbid relationship between migraine and depression has been well recognized, but its underlying pathophysiology is unclear. Here, we aimed to explore the structural changes of the amygdala and the abnormal functional connectivity of the centromedial amygdala (CMA) in migraineurs with depression.MethodsHigh‐resolution T1‐weighted and functional magnetic resonance images were acquired from 22 episodic migraineurs with comorbid depression (EMwD), 21 episodic migraineurs without depression (EM), and 17 healthy controls (HC). Voxel‐based morphometry and resting‐state functional connectivity (rsFC) were applied to examine the intergroup differences in amygdala volume.ResultsThe bilateral amygdala volume was increased in the EMwD and EM groups compared with the HC group, but there were no differences between the EMwD and EM groups. The right CMA exhibited decreased rsFC in the left dorsolateral prefrontal cortex (DLPFC) in the EMwD group compared with the EM group, while rsFC increased between the CMA and the contralateral DLPFC in the EM group compared with the HC group. In addition, the EM group showed decreased rsFC between the left CMA and the left pallidum compared with the HC group.ConclusionsEnlarged amygdala is an imaging feature of EM and EMwD. The inconsistency of rsFC between CMA and DLPFC between migraineurs with and without depression might indicate that decreased rsFC between CMA and DLPFC is a neuropathologic marker for the comorbidity of migraine and depression. The core regions might be a potential intervention target for the treatment of EMwD in the future.

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Common pathomechanism of migraine and depression

Cited by 5 publications

References 51 publications

Pathophysiological Mechanisms and Pharmaceutical Interventions of Myocardial Infarction with Depression

Pathophysiological Mechanisms and Pharmaceutical Interventions of Myocardial Infarction with Depression

Understanding the Biological Relationship between Migraine and Depression

Alterations of amygdala volume and functional connectivity in migraine patients comorbid with and without depression

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