Common Pacemaker Problems: Lead and Pocket Complications

Gül, Enes Elvin; Kayrak, Mehmet

doi:10.5772/12965

Cited by 5 publications

(2 citation statements)

References 70 publications

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“…First, we can contactlessly stimulate the cardiac muscle without pacing leads. Pacing leads attached to inside of the right atrium and the right ventricle in major conventional artificial pacemakers occasionally cause complications such as disconnection, cardiac perforation, or venous stenosis ( Hirschl et al, 2007 ; Gul and Kayrak, 2011 ; Sadamatsu, 2011 ). Lead replacement surgery is required to address these complications, which has its own potential risks.…”

Section: Discussionmentioning

confidence: 99%

The physiological response during optogenetic-based cardiac pacing in awake freely moving mice

Kaminosono,

Kambe,

Tanimoto

et al. 2023

Front. Physiol.

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There are several methods to control a heart rate, such as electrical stimulation and drug administration. However, these methods may be invasive or affect other organs. Recently, an optogenetic-based cardiac pacing method has enabled us to stimulate the cardiac muscle in non-contact. In many previous studies, the pacing was applied ex vivo or in anesthetized animals. Therefore, the physiologic response of animals during optogenetic pacing remains unclear. Here, we established a method of optogenetic-based cardiac pacing in awake, freely moving mice and simultaneously measured electrocardiogram, blood pressure, and respiration. As a result, light-induced myocardial contraction produces blood flow and indirectly affects the respiration rhythm. Additionally, light illumination enabled heart rate recovery in bradycardic mice. These findings may be employed for further research that relates a heartbeat state to animal behavior. Together, this method may drive the development of less invasive pacemakers without pacing leads.

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Section: Discussionmentioning

confidence: 99%

The physiological response during optogenetic-based cardiac pacing in awake freely moving mice

Kaminosono,

Kambe,

Tanimoto

et al. 2023

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…3 Other complications associated with pacemaker leads include lead dislodgement, phlebitis, myocardial perforation, and complete fragmentation of the pacemaker lead. [4][5][6] These complications can cause significant morbidity and mortality, and it is crucial for clinicians to be aware of these potential complications to diagnose and treat them promptly.…”

Section: Introductionmentioning

confidence: 99%