Common mental disorders and association with telomere length (Review)

Vakonaki, Elena; Tsiminikaki, Konstantina; Plaitis, Stavros; Fragkiadaki, Persefoni; Tsoukalas, Dimitris; Katsikantami, Ioanna; Vaki, Georgia; Tzatzarakis, Manolis; Spandidos, Demetrios Α.; Tsatsakis, Aristidis

doi:10.3892/br.2018.1040

Cited by 31 publications

(35 citation statements)

References 82 publications

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“…A growing body of literature links short TL from peripheral proxy tissues, such as leukocytes, with the onset and progression of neurodegenerative and psychiatric disorders, and chronic stress (27,55,(64)(65)(66). However, in the present study stress reactivity, although influential in heart telomere length, did not affect the rate of telomere attrition in the brain.…”

Section: Discussioncontrasting

confidence: 74%

“…Interestingly, the likelihood of onset and progression of age-related diseases is associated with an anxious personality (19)(20)(21) and HPA axis dysfunction (22,23). It is therefore thought that an exacerbated stress response may contribute to telomere shortening, accelerated ageing and, in turn, age-related disease (24)(25)(26)(27)(28). Additionally, telomere shortening can influence replicative senescence indirectly via downstream regulators such as SMAD specific E3 ubiquitin-ligase 3 (Smurf2) (29,30) thus telomere length might be mediating other physiological aspects associated with ageing.…”

Section: Introductionmentioning

confidence: 99%

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Stress reactivity elicits a tissue-specific reduction in telomere length in ageing zebrafish (Danio rerio)

Evans

Torres-Pérez

Petrazzini

et al. 2020

Preprint

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Telomere length reflects cellular ageing. Increased telomere shortening in leukocytes is associated with a range of neurodegenerative and cardiovascular diseases, the onset and progression of which may be mediated by behavioural traits such as anxiety and stress reactivity. However, the effects of the hypothalamus-pituitary-adrenal axis stress response are shown to be tissue specific. As such, leukocyte telomere length may not give an accurate measure of the relationship between stress-reactivity and telomere length in disease relevant tissues. To test the hypothesis that stress-reactivity contributes to age-related telomere shortening in a tissue specific manner, we examined the correlation between telomere length in heart and brain tissue and stress-reactivity in a population of young (6-9 month) and ageing (18 month) zebrafish. Stress-reactivity was assessed by tank diving, a zebrafish version of the rodent open-field test, and through gene expression. Telomere length was assessed using quantitative polymerase chain reaction. We show that ageing zebrafish have shorter telomeres in both heart and brain. Telomere length is inversely related to stress-reactivity in heart but not brain of ageing individuals. These data support the hypotheses that an anxious predisposition contributes to telomere shortening in heart tissue, and by extension age-related heart disease, and that stress-reactivity contributes to age-related telomere shortening in a tissue-specific manner.

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Section: Discussioncontrasting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Stress reactivity elicits a tissue-specific reduction in telomere length in ageing zebrafish (Danio rerio)

Evans

Torres-Pérez

Petrazzini

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…TL and telomerase activity are strongly associated with human health as they have been linked to several age-related diseases, such as cancer, cardiovascular disease (CAD), diabetes, rheumatoid arthritis and psychiatric disorders (34)(35)(36)(37)(38). Moreover, previous studies have suggested that female human fertility decreases with an increased maternal age and that various adverse factors, including reduced telomerase activity, can contribute to age-associated infertility in women (39,40).…”

Section: Role Of Telomeres and Telomerase In Agingmentioning

confidence: 99%

Telomere length and telomerase activity in osteoporosis and osteoarthritis (Review)

et al. 2019

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Osteoarthritis (OA) and osteoporosis (OP) are associated skeletal pathologies and have as a distinct feature the abnormal reconstruction of the subchondral bone. OA and OP have been characterized as age-related diseases and have been associated with telomere shortening and altered telomerase activity (TA). This review discusses the role of telomeres and telomerase in OA and OP pathologies and focuses on the usability of telomere length (TL) and the rate of telomere shortening as potential disease biomarkers. A number of studies have demonstrated that telomere shortening may contribute to OA and OP as an epigenetic factor. Therefore, it has been claimed that the measurement of TL of chondrocytes and/or peripheral blood cells may be an appropriate marker for the evaluation of the progression of these diseases. However, there is a need to be perform further studies with larger cohorts, with the aim of obtaining objective results and a better understanding of the association between TL, inflammation and aging, in order to provide further insight into the pathophysiology of degenerative joint diseases.

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“…Telomeres are highly conserved non-coding tandem repeats (5'-TTAGGG-3') located at the extreme end of chromosomes, coated by a complex of 6 proteins, termed the 'shelterin complex' and they are essential for genomic stability and integrity. The telomeric length of human germ cells (10-20 kb) is longer compared to that of human somatic cells (5-10 kb) (1). Telomeric length is heritable and varies with sex, as females have longer telomeres due to the presence of estrogen (2).…”

Section: Introductionmentioning

confidence: 99%

Sperm telomere length: Diagnostic and prognostic biomarker in male infertility (Review)

et al. 2020

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Telomere length is an important biomarker in a number of diseases, including male infertility. A decreased telomere length has been reported in several diseases and telomere shortening may occur due to aging, decreased telomerase activity, oxidative stress or cell division. In recent years, several studies have indicated that males with infertility have a shorter sperm telomere length than fertile males. Sperm telomere shortening is associated with male infertility through several mechanisms, including the apoptosis of spermatozoa, decreased motility, low sperm count, incorrect chromosomal pairing and movement during meiosis, and failed fertilization. The aim of this review was to compile current findings on sperm telomere length and discuss findings to compare sperm from infertile males with that of fertile males. Several studies reported shortening of sperm telomeres associated with infertility. Thus, sperm telomere length can be used as biomarker for the diagnosis and prognosis of male infertility, since fertile males have longer telomeres and the length decreases with age. However, there is no specific telomere length that is set as standard/recommended length. Contents 1. Introduction 2. Telomere length in sperm cells 3. Telomere length and male infertility 4. Role of sperm telomere in diagnosis and prognosis of male infertility 5. Conclusions

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Common mental disorders and association with telomere length (Review)

Cited by 31 publications

References 82 publications

Stress reactivity elicits a tissue-specific reduction in telomere length in ageing zebrafish (Danio rerio)

Stress reactivity elicits a tissue-specific reduction in telomere length in ageing zebrafish (Danio rerio)

Telomere length and telomerase activity in osteoporosis and osteoarthritis (Review)

Sperm telomere length: Diagnostic and prognostic biomarker in male infertility (Review)

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