Common lupus anti-DNA antibody idiotypes in chronic liver diseases

Konikoff, Fred M.; Isenberg, David; Kooperman, O.; Kennedy, Ronald C.; Rauch, Joyce; Theodor, E; Shoenfeld, Yehuda

doi:10.1016/0090-1229(87)90134-6

Cited by 24 publications

(11 citation statements)

References 18 publications

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“…Anti-DNA has been previously associated with chronic liver diseases [26]. Elevated AST relative to ALT has been associated with alcoholic hepatitis as well as progression of chronic viral hepatitis to cirrhosis [8,27].…”

Section: Discussionmentioning

confidence: 99%

Liver injury correlates with biomarkers of autoimmunity and disease activity and represents an organ system involvement in patients with systemic lupus erythematosus

Liu

Oaks

et al. 2015

Clinical Immunology

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Liver disease (LD), defined as ≥2-fold elevation of aspartate aminotransferase (AST) or alanine aminotransferase (ALT), was examined in a longitudinal study of systemic lupus erythematosus (SLE) patients. Among 435 patients, 90 (20.7%) had LD with a greater prevalence in males (15/39; 38.5%) than females (75/396; 18.9%; p = 0.01). SLE disease activity index (SLEDAI) was greater in LD patients (7.8 ± 0.7) relative to those without (5.8 ± 0.3; p = 0.0025). Anti-smooth muscle antibodies, anti-DNA antibodies, hypocomplementemia, proteinuria, leucopenia, thrombocytopenia, and anti-phospholipid syndrome were increased in LD. An absence of LD was noted in patients receiving rapamycin relative to azathioprine, cyclosporine A, or cyclophosphamide. An absence of LD was also noted in patients treated with N-acetylcysteine. LFTs were normalized and SLEDAI was diminished with increased prednisone use in 76/90 LD patients over 12.1 ± 2.6 months. Thus, LD is attributed to autoimmunity and disease activity, it responds to prednisone, and it is potentially preventable by rapamycin or N-acetylcysteine treatment.

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Section: Discussionmentioning

confidence: 99%

Liver injury correlates with biomarkers of autoimmunity and disease activity and represents an organ system involvement in patients with systemic lupus erythematosus

Liu

Oaks

et al. 2015

Clinical Immunology

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“…An association of ENA response with liver disease has been described in children with autoimmune hepatitis, where anti-ENA-positive patients demonstrated more severe liver test abnormalities than those who were anti-ENA-negative [32]. In another study, a 15 % of patients with various chronic liver diseases were found to be anti-RNP positive [33]. …”

Section: Discussionmentioning

confidence: 99%

The liver is a common non-exocrine target in primary Sjögren's syndrome: A retrospective review

Kaplan

Ike

2002

BMC Gastroenterol

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“…Three weeks later, a booster injection of I /Lg of SA-I in phosphate buffered saline (PBS) was administered to the hind footpads (8). The presence of autoantibodies against single-stranded DNA, dsDNA, poly(l), poly(G), histones (subfractions Hl-H5), cardiolipin, Sm, RNP, SS-A/Ro, SS-B/La, and 16/6 Id idiotype in the serum was determined by enzyme-linked immunosorbent assay (ELISA) (5,6,8,20,21). The mice were bled through their orbits, with 300 /Ll of serum obtained from each animal.…”

Section: Methodsmentioning

confidence: 99%

The effect of cyclosporin a on early and late stages of experimental lupus

Blank

Ben-Bassat

Shoenfeld

1992

Arthritis & Rheumatism

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Objective. To investigate the effect of cyclosporin A (CSA) on the development of lupus in an experimental model.Methods. Lupus was induced in naive mice following injection of a human anti-double-stranded DNA (anti-dsDNA) monoclonal antibody carrying the 16/6 idiotype (Id). CSA was injected into the mice at an early stage of the disease (2 months after immunization) and at a late stage (4 months after immunization).Results. CSA was found to have a suppressive effect on autoantibody production, as well as on the appearance of other disease manifestations, in the mice with lupus. The effects of the drug were more prominent when the mice were treated at an early stage. This was reflected by a dramatic decrease, to normal levels, in autoantibodies to dsDNA, histones, cardiolipin, Sm, RNP, SS-A/Ro, SS-B/La, and anti-DNA 16/6 Id. Similar effects on the erythrocyte sedimentation rate, white blood cell count, and urinary protein levels were noted.

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Common lupus anti-DNA antibody idiotypes in chronic liver diseases

Cited by 24 publications

References 18 publications

Liver injury correlates with biomarkers of autoimmunity and disease activity and represents an organ system involvement in patients with systemic lupus erythematosus

Liver injury correlates with biomarkers of autoimmunity and disease activity and represents an organ system involvement in patients with systemic lupus erythematosus

The liver is a common non-exocrine target in primary Sjögren's syndrome: A retrospective review

The effect of cyclosporin a on early and late stages of experimental lupus

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