Common herbs, essential oils, and monoterpenes potently modulate bone metabolism

Mühlbauer, R. C.; Lozano, Annemarie; Palacio, S; Reinli, Andreas; Félix, R.

doi:10.1016/s8756-3282(03)00027-9

Cited by 123 publications

(98 citation statements)

References 30 publications

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“…Interestingly, essential oils and monoterpenes present in common herbs have been shown to inhibit bone resorption when added to the food of rats (Muhlbauer et al, 2003), but this is the first report that a low concentration of 3-carene, a monoterpene, stimulates the mineralization in osteoblastic cells and its activity could result from its potential to promote the activation of MAP kinase signaling pathways.…”

Section: Discussionmentioning

confidence: 93%

Low concentration of 3‐carene stimulates the differentiation of mouse osteoblastic MC3T3‐E1 subclone 4 cells

Jeong

Kim

Min

et al. 2007

Phytotherapy Research

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Recently, natural products have gained more interest as alternative treatments for metabolic bone disorders and for the maintenance of bone health. In this study, the anabolic activities of 89 natural compounds were evaluated by measuring the amount of newly synthesized calcium in the differentiation process of mouse osteoblastic MC3T3-E1 subclone 4 cells. Of these compounds, a low concentration (up to 5 μ μ μ μ μM) of 3-carene, which is a bicyclic monoterpene in essential oils extracted from pine trees, was shown to stimulate significantly the activity and expression of alkaline phosphatase, an early phase marker of osteoblastic differentiation, on differentiation day 9. On day 15, it dramatically promoted the induction of calcium in a dose-dependent manner. The stimulatory effect of 3-carene on mineralization might be associated with its potential to induce the protein expression/activation of the mitogen-activated protein kinases and the transcript levels of osteoblast mineralization-related genes such as osteopontin and type I collagen. Further studies are needed to determine the precise mechanism, but the anabolic activity of 3-carene in bone metabolism suggested that the use of natural additives to the diet including essential oils could have a beneficial effect on bone health.

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Section: Discussionmentioning

confidence: 93%

Low concentration of 3‐carene stimulates the differentiation of mouse osteoblastic MC3T3‐E1 subclone 4 cells

Jeong

Kim

Min

et al. 2007

Phytotherapy Research

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“…Quercetin from onion extract inhibits the differentiation of osteoclast progenitor into pre-osteoclasts and actin ring formation (24). Essential oils derived from rosemary, thyme and other herbs inhibit osteoclast activity in vitro (25). Ethanol extract from the Formosan orchid Anoectochilus formosanus suppressed bone loss caused by estrogen deficiency through the suppression of RANKL expression that is required for osteoclast formation (26).…”

Section: Discussionmentioning

confidence: 99%

Suppressive Effects of the Leaf of Terminalia catappa L. on Osteoclast Differentiation In Vitro and Bone Weight Loss In Vivo

Koyama

Nakajima

Nishimoto

et al. 2012

J Nutr Sci Vitaminol

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Summary Oral administration of Terminalia catappa extract (TCE; 1,000 mg/kg) for 5 wk suppressed bone weight loss and trabecular bone loss in ovariectomized mice. An in vitro experiment showed that TCE (1.3-20 g/mL) did not increase alkaline phosphatase activity, which would indicate osteoclast formation, in osteoblast-like 3T3-L1 cells. On the other hand, TCE (12.5 g/mL) markedly decreased the number of tartrate resistant acid phosphatase (TRAP)-positive multinucleated cells, which would indicate osteoclast formation, in a co-culture system (bone marrow cells/osteoblastic UAMS-32 cells). A detailed analysis of the stages of osteoclast differentiation revealed that TCE mainly suppressed the differentiation of bone marrow mononuclear cells into osteoclast progenitor cells in the presence of M-CSF and TGF-␤ . An additional experiment using fractionated TCE revealed that the watersoluble fraction suppressed the bone weight loss in OVX-mice and osteoclast differentiation in vitro. Therefore, the suppressive effects of TCE on bone weight loss in mice might be due to the suppressive effects of highly polar components on the early stage of osteoclast differentiation.

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“…Among those, borneol is a bicyclic monoterpene present in several medicinal plants (91)(92)(93)(94). Previous studies showed that borneol has free radical scavenging activity (95) and is a major component of essential oil of SuHeXiang Wan (92) whose neuroprotective function has been reported in in vivo and in vitro models of Alzheimer's disease (AD) (96)(97)(98)(99).…”

Section: Terpenes and Neuronal Healthmentioning

confidence: 99%

Terpenes from Forests and Human Health

et al. 2017

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Forest bathing has beneficial effects on human health via showering of forest aerosols as well as physical relaxation. Terpenes that consist of multiple isoprene units are the largest class of organic compounds produced by various plants, and one of the major components of forest aerosols. Traditionally, terpene-containing plant oil has been used to treat various diseases without knowing the exact functions or the mechanisms of action of the individual bioactive compounds. This review categorizes various terpenes easily obtained from forests according to their anti-inflammatory, anti-tumorigenic, or neuroprotective activities. Moreover, potential action mechanisms of the individual terpenes and their effects on such processes, which are described in various in vivo and in vitro systems, are discussed. In conclusion, the studies that show the biological effectiveness of terpenes support the benefits of forest bathing and propose a potential use of terpenes as chemotherapeutic agents for treating various human diseases.

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Common herbs, essential oils, and monoterpenes potently modulate bone metabolism

Cited by 123 publications

References 30 publications

Low concentration of 3‐carene stimulates the differentiation of mouse osteoblastic MC3T3‐E1 subclone 4 cells

Low concentration of 3‐carene stimulates the differentiation of mouse osteoblastic MC3T3‐E1 subclone 4 cells

Suppressive Effects of the Leaf of Terminalia catappa L. on Osteoclast Differentiation In Vitro and Bone Weight Loss In Vivo

Terpenes from Forests and Human Health

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