Common Hematological Abnormalities in patients with Malaria presenting at Saidu Teaching Hospital, Swat Pakistan

Ahad, Abdul; Qadir, Saima Yasmin; Rashid, Aleem ur; Swati, Amir Zeb

doi:10.53350/pjmhs22164298

Cited by 3 publications

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“…This can be explained by the invasion of hepatic cells by the parasite and the leakage of liver enzymes into the circulation. The increase in liver enzyme levels is also proportional to the severity of the malaria infection ( Megabiaw et al, 2022 ; Ahad et al, 2022 ). Liver dysfunction in malaria cases results from congestion, cellular inflammation, and sinusoidal blockage caused by the parasite ( Auta, Zakariyya & Everest, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

Malaria: biochemical, physiological, diagnostic, and therapeutic updates

El Saftawy,

Farag,

Gebreil

et al. 2024

PeerJ

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Background Malaria has been appraised as a significant vector-borne parasitic disease with grave morbidity and high-rate mortality. Several challenges have been confronting the efficient diagnosis and treatment of malaria. Method Google Scholar, PubMed, Web of Science, and the Egyptian Knowledge Bank (EKB) were all used to gather articles. Results Diverse biochemical and physiological indices can mirror complicated malaria e.g., hypoglycemia, dyslipidemia, elevated renal and hepatic functions in addition to the lower antioxidant capacity that does not only destroy the parasite but also induces endothelial damage. Multiple trials have been conducted to improve recent points of care in malaria involving biosensors, lap on-chip, and microdevices technology. Regarding recent therapeutic trials, chemical falcipain inhibitors and plant extracts with anti-plasmodial activities are presented. Moreover, antimalaria nano-medicine and the emergence of nanocarrier (either active or passive) in drug transportation are promising. The combination therapeutic trials e.g., amodiaquine + artemether + lumefantrine are presented to safely counterbalance the emerging drug resistance in addition to the Tafenoquine as a new anti-relapse therapy. Conclusion Recognizing the pathophysiology indices potentiate diagnosis of malaria. The new points of care can smartly manipulate the biochemical and hematological alterations for a more sensitive and specific diagnosis of malaria. Nano-medicine appeared promising. Chemical and plant extracts remain points of research.

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Section: Resultsmentioning

confidence: 99%

Malaria: biochemical, physiological, diagnostic, and therapeutic updates

El Saftawy,

Farag,

Gebreil

et al. 2024

PeerJ

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“…The remaining 70 articles were further examined for eligibility, and 34 articles were excluded for the following reasons: no full-texts (n = 13), no records of articles (n = 8), unable to extract data (n = 6), non-English articles (n = 3), poster or conference abstracts (n = 2), reviews (n = 1), and an animal study (n = 1). A total of 37 studies [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ] met the criteria and were included in the study. Another study [ 62 ] was identified from searches on Google Scholar.…”

Section: Resultsmentioning

confidence: 99%

“…Another study [ 62 ] was identified from searches on Google Scholar. Finally, 38 studies [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ] were included in the study for final analysis ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Half of the studies were published between 2010 and 2022 (50%). Studies were conducted in six countries in Asia (71.1%) [ 25 , 26 , 28 , 29 , 31 , 32 , 33 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 43 , 45 , 46 , 48 , 49 , 50 , 51 , 54 , 58 , 59 , 60 , 61 , 62 ], four countries in Europe (10.5%) [ 34 , 42 , 52 , 56 ], two countries in Africa (7.89%) [ 27 , 44 , 47 ], North America (the United States) [ 30 , 55 , 57 ], and South America and Asia (Brazil and India) [ 53 ]. Most studies enrolled patients infected with P. falciparum (44.7%) and more than half of them in adult participants (60.5%).…”

Section: Resultsmentioning

confidence: 99%

“…According to the STROBE criteria that assessed the study’s quality with an overall score of 22 items, two studies received high scores [ 47 , 53 ]. The remaining 22 studies had moderate scores [ 25 , 26 , 28 , 32 , 35 , 36 , 37 , 39 , 40 , 42 , 43 , 44 , 48 , 49 , 50 , 51 , 52 , 55 , 57 , 58 , 59 , 61 ], and 14 studies had low scores [ 27 , 29 , 30 , 31 , 33 , 34 , 38 , 41 , 45 , 46 , 54 , 56 , 60 , 62 ], respectively. All studies were included in the meta-analysis of the proportion.…”

Section: Resultsmentioning

confidence: 99%

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A Systematic Review and Meta-Analysis of the Proportion Estimates of Disseminated Intravascular Coagulation (DIC) in Malaria

et al. 2023

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Disseminated intravascular coagulation (DIC) is a potentially life-threatening condition that causes systemic coagulation to be turned on and coagulation factors to be used up. However, the evidence for DIC in malaria patients is still not clear, and small case series and retrospective studies have shown varying results. This meta-analysis was intended for the evaluation of the evidence of DIC among malaria patients using a meta-analysis approach. The protocol for the systematic review was registered at PROSPERO as CRD42023392194. Studies that investigated DIC in patients with malaria were searched in Ovid, Scopus, Embase, PubMed, and MEDLINE. The pooled proportion with 95% confidence intervals (CI) of DIC among malaria patients was estimated using a random-effects model. A total of 1837 articles were identified, and 38 articles were included in the meta-analysis. The overall proportion of DIC in malaria was 11.6% (95% CI: 8.9%–14.3%, I2: 93.2%, 38 studies). DIC in severe falciparum malaria and fatal malaria was 14.6% (95% CI: 5.0–24.3%, I2: 95.5%, 11 studies) and 82.2% (95% CI: 56.2–100%, I2: 87.3, 4 studies). The estimates of DIC among severe malaria patients who had multi-organ dysfunction with bleeding, cerebral malaria, acute renal failure, and ≥2 complications were 79.6% (95% CI: 67.1–88.2%, one study), 11.9% (95% CI: 7.9–17.6%, one study), 16.7% (95% CI: 10.2–23.3%, ten studies), and 4.8% (95% CI: 1.9–7.7%, nine studies), respectively. The proportion estimates of DIC among the patients with malaria depended on the Plasmodium species, clinical severity, and types of severe complications. The information from this study provided useful information to guide the management of malaria patients. Future studies are needed to investigate the association between Plasmodium infection and DIC and to understand the mechanism of malaria-induced DIC.

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Severity of Plasmodium vivax Malaria among Patients Presenting at Tertiary Care Hospital after Flood in Sindh – Pakistan

Humaira,

Memon,

Abro

et al. 2023

PJHS

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Malaria is one of the widely spread vector bond infectious disease responsible for grave health issues. Pakistan is one of the adversely hit country by malaria. We conducted this study to access whether there was only increase in no of malaria patients after flood in Sindh patients or clinical variance is also there. Objective: To assess the severity of Plasmodium vivax infection at a tertiary care hospital, after flood situation in Sindh. Methods: This cross-sectional study was conducted at LUMHS, Jamshoro from November 2022 to April 2023. After taking inform written consent, adult patients of age 13 to 60 years, irrespective of gender, with positive report of P. vivax malaria were included in the study. Data were recorded on predesigned proforma. Severity of malaria was determined according to the classification criteria. Data were analyzed with the help of SPSS version 23. Results: Out of total 170 patients, 52.4% female, mean age was 26.6 year. 50.6% patients of Plasmodium vivax found to suffer from severe malaria. Severe anemia, ALOC and jaundice were present in 28.2%, 21.2% and 11.2% of patients respectively. Conclusions: Enormous number of severe malaria cases due to of P. vivax was detected after floods in Sindh. Young age people were affected more, irrespective of gender. Severe anemia was the most common complication of malaria. Thrombocytopenia found frequently in patients infected with P. vivax.

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Common Hematological Abnormalities in patients with Malaria presenting at Saidu Teaching Hospital, Swat Pakistan

Cited by 3 publications

References 0 publications

Malaria: biochemical, physiological, diagnostic, and therapeutic updates

Malaria: biochemical, physiological, diagnostic, and therapeutic updates

A Systematic Review and Meta-Analysis of the Proportion Estimates of Disseminated Intravascular Coagulation (DIC) in Malaria

Severity of Plasmodium vivax Malaria among Patients Presenting at Tertiary Care Hospital after Flood in Sindh – Pakistan

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