Common Genetic Variants on 6q24 Associated With Exceptional Episodic Memory Performance in the Elderly

Barral, Sandra; Cosentino, Stephanie; Christensen, Kaare; Newman, Anne B.; Perls, Thomas T.; Province, Michael A.; Mayeux, Richard

doi:10.1001/jamaneurol.2014.1663

Cited by 14 publications

(11 citation statements)

References 22 publications

(24 reference statements)

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“…Moreover, the increased prevalence of APOE E2 in the cluster of slowest changers of DSST is consistent with the growing evidence of a neuroprotective role of APOE E2 (Kim et al 2017) that could be linked to the longevity-associated mechanism of E2 (Sebastiani et al 2018). A comprehensive analysis of genetic variants associated with patterns of change of various cognitive functions is beyond the scope of this manuscript, but consistently with the large heritability of results on neuropsychological tests found by us and other investigators (Barral et al 2014;Matteini et al 2010), we expect that genetic factors in addition to APOE may be an important determinants of these changes.…”

Section: Risk Factorssupporting

confidence: 87%

Patterns of multi-domain cognitive aging in participants of the Long Life Family Study

et al. 2020

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Maintaining good cognitive function at older age is important, but our knowledge of patterns and predictors of cognitive aging is still limited. We used Bayesian model-based clustering to group 5064 participants of the Long Life Family Study (ages 49-110 years) into clusters characterized by distinct trajectories of cognitive change in the domains of episodic memory, attention, processing speed, and verbal

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Section: Risk Factorssupporting

confidence: 87%

Patterns of multi-domain cognitive aging in participants of the Long Life Family Study

et al. 2020

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“…111), biosynthesis of neurotransmitters (Ref. 112), ubiquitin metabolism and immune system (Ref. 113).…”

Section: Brain Genetic Resistance Factors: Studies In Healthy Peoplementioning

confidence: 99%

Genome research in pre-dementia stages of Alzheimer's disease

Moreno‐Grau

Ruiz

2016

Expert Rev. Mol. Med.

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Genetic characterization of individuals at risk of Alzheimer's disease (AD), i.e. people having amyloid deposits in the brain without symptoms, people suffering from subjective cognitive decline (SCD) or mild cognitive impairment (MCI), has spurred the interests of researchers. However, their pre-dementia genetic profile remains mostly unexplored. In this study, we reviewed the loci related to phenotypes of AD, MCI and SCD from literature and performed the first meta-analyses evaluating the role of apolipoprotein E (APOE) in the risk of conversion from a healthy status to MCI and SCD. For AD dementia risk, an increased number of loci have been identified; to date, 28 genes have been associated with Late Onset AD. In MCI syndrome, APOE is confirmed as a pheno-conversion factor leading from MCI to AD, and clusterin is a promising candidate. Additionally, our meta-analyses revealed APOE as genetic risk factor to convert from a healthy status to MCI [OR = 1.849 (1.587-2.153); P = 2.80 × 10-15] and to a lesser extent from healthy status to SCD [OR = 1.151 (1.015-1.304); P = 0.028]. Thus, we believe that genetic studies in longitudinal SCD and MCI series may provide new therapeutic targets and improve the existing knowledge of AD. This type of studies must be completed on healthy subjects to better understand the natural disease resistance to brain insults and neurodegeneration.

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“…This approach was deliberately chosen to identify the most extreme families for genetic analysis. Consistent with these findings, linkage signals for phenotypes in LLFS have been shown to be driven by a very small number of families (Barral et al 2014;Lee et al 2014). It is quite possible that not all longlived individuals make it to extreme ages in the same way (Evert et al 2003;Perls 2006;Ukraintseva et al 2016).…”

Section: Discussionmentioning

confidence: 61%

Heterogeneity of healthy aging: comparing long-lived families across five healthy aging phenotypes of blood pressure, memory, pulmonary function, grip strength, and metabolism

Marron

Wojczynski²,

Minster³

et al. 2019

GeroScience

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Five healthy aging phenotypes were developed in the Long Life Family Study to uncover longevity pathways and determine if healthy aging across multiple systems clustered in a subset of long-lived families. Using blood pressure, memory, pulmonary function, grip strength, and metabolic measures (body mass index, waist circumference and fasting levels of glucose, insulin, triglycerides, lipids, and inflammatory markers), offspring were ranked according to relative health using gender-, age-, and relevant confounder-adjusted z-scores. Based on our prior work, families met a healthy aging phenotype if ≥ 2 and ≥ 50% of their offspring were exceptionally healthy for that respective phenotype. Among 426 families, only two families met criteria for three healthy aging phenotypes and none met criteria for four or more healthy aging phenotypes. Using Spearman correlation, the

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Common Genetic Variants on 6q24 Associated With Exceptional Episodic Memory Performance in the Elderly

Cited by 14 publications

References 22 publications

Patterns of multi-domain cognitive aging in participants of the Long Life Family Study

Patterns of multi-domain cognitive aging in participants of the Long Life Family Study

Genome research in pre-dementia stages of Alzheimer's disease

Heterogeneity of healthy aging: comparing long-lived families across five healthy aging phenotypes of blood pressure, memory, pulmonary function, grip strength, and metabolism

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