Common genetic polymorphisms in pre‐microRNAs and risk of cervical squamous cell carcinoma

Zhou, Bin; Wang, Kana; Wang, Yanyun; Xi, Mingrong; Zhu, Zhou; Song, Yaping; Zhang, Lin

doi:10.1002/mc.20740

Cited by 83 publications

(79 citation statements)

References 32 publications

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“…These results are in agreement with those reported for breast cancer, since the authors had shown that the variant A > G of miR-499 is associated with a significantly increased risk of developing this cancer, with a 1.75 odd risk [38]. Similarly, the G allele was found to be significantly associated with an increased risk of cervical squamous cell carcinoma [42]. Even if both these two published studies suggested a role for the G allele in determining an increased incidence for respective cancers, no functional connection was previously demonstrated to support the relationship between genotype and cancer risk.…”

Section: Discussionsupporting

confidence: 92%

Genetic and epigenetic factors in regulation of microRNA in colorectal cancers

Vinci

Gelmini

Mancini

et al. 2013

Methods

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a b s t r a c tStudies on miRNA profiling revealed that a large number of them are significantly deregulated in human cancers. The molecular mechanisms of this deregulation are not totally clarified, even if genetics and epigenetics are frequently involved.Single nucleotide polymorphisms (SNPs) are the most common type of genetic variation in the human genome. A SNP into miRNA gene might affect the transcription of primary miRNA, its processing and miRNA-mRNA interaction. We investigated the distribution of sequence variants of miR-146a, miR-196a2, miR-499 and miR-149 in colorectal cancer (CRC) and their effect on miRNA expression. Each variant was identified with HRM. For miR-499 we demonstrated a significant reduction of its expression in CRC connected to a specific genotype.To evaluate the epigenetic effects on miRNA genes in CRC, we investigated the influence of DNA methylation on miR-34b, miR-34c and miR-9-1 expression. We aimed to verify the relationship between the methylation status of these miRNA genes and their relative expression in tumor samples. For the quantification of DNA methylation we adopted a method based on Differential High Resolution Melting (D-HRM).

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Section: Discussionsupporting

confidence: 92%

Genetic and epigenetic factors in regulation of microRNA in colorectal cancers

Vinci

Gelmini

Mancini

et al. 2013

Methods

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“…There were fifteen studies of caucasian descent and twenty-four studies of Asian descent. The genotype distributions in the controls of fourteen studies were not conforming to HWE (p<0.05) (Okubo et al, 2010;Akkiz et al, 2011;Ling et al, 2011;Mittal et al, 2011;Zhou et al, 2011;Xiang et al, 2012;Shan et al, 2013;Vinci et al, 2013;Wei et al, 2013;Zou and Zhao, 2013;Bansal et al, 2014;Ma et al, 2014;Omrani et al, 2014;Wang et al, 2014).…”

Section: Methodsmentioning

confidence: 99%

“…One study was excluded as it was not associated with hsa-mir-499 rs3746444 A>G (Kupcinskas et al, 2012). After further excluding two abstracts (Hu et al, 2009;Hwang et al, 2010), thirty-nine case-control studies involving 14,136 cases and 16,937 controls were selected for meta-analysis (Hu et al, 2009;Tian et al, 2009;Catucci et al, 2010;Liu et al, 2010;Okubo et al, 2010;Srivastava et al, 2010;Akkiz et al, 2011;George et al, 2011;Ling et al, 2011;Mittal et al, 2011;Vinci et al, 2011;Zhou et al, 2011;Alshatwi et al, 2012;Chu et al, 2012;Kim et al, 2012;Min et al, 2012;Xiang et al, 2012;Zhou et al, 2012;Ahn et al, 2013;Lv et al, 2013;Shan et al, 2013;Song et al, 2013;Umar et al, 2013;Vinci et al, 2013;Wei et al, 2013;Wu et al, 2013;Zou and Zhao, 2013;Bansal et al, 2014;Chu et al, 2014;Du et al, 2014;Gutierrez-Camino et al, 2014;Hasani et al, 2014;Hou et al, 2014;Hu et al, 2014;Ma et al, 2014;Omrani et al, 2014;Pu et ...…”

Section: Methodsmentioning

confidence: 99%

Lack of Association between Hsa-Mir-499 rs3746444 Polymorphism and Cancer Risk: Meta-analysis Findings

Jiang

Chen²,

Tang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Epidemiologic findings concerning the association between the hsa-mir-499 rs3746444 A>G polymorphism and cancer risk have yielded mixed results. We aimed to investigate the association by performing a meta-analysis of all available studies. We searched PubMed and EMBASE for studies published up to November 2014, using odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of any association. The BenjaminiHochberg (BH) method was used to correct the p values for multiple comparisons. We included 39 studies, including 14,136 cases and 16,937 controls. The results of overall meta-analysis suggested a borderline association between hsa-mir-499 rs3746444 polymorphism and cancer susceptibility (AG+GG vs. AA: OR=1.15, 95% CI= 1.04-1.26, corrected p value=0.04). After removing studies not conforming to Hardy-Weinberg equilibrium (HWE), however, this association disappeared (AG+GG vs AA: OR=1.18, 95% CI=1.03-1.34, corrected p value=0.21). When stratified analysis by ethnicity, cancer type or HWE in controls, although some associations between hsa-mir-499 rs3746444 polymorphism and cancer susceptibility were detected, these associations no longer existed after adjustment using BH method. In conclusion, our meta-analysis suggests that hsa-mir-499 rs3746444 A>G polymorphism is not associated with risk of cancer based on current evidence. conclusive. Many meta-analyses have examined the association of the polymorphism with cancer risk and the lasted one suggested that hsa-mir-499 rs3746444 polymorphism was a risk factor for cancer development. Since the latest meta-analysis had been performed, nineteen case-control studies (Ling

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“…The study selection process is shown in Figure 1. Finally, 22 articles (Jazdzewski et al, 2008;Xu et al, 2008;Hoffman et al, 2009;Hu et al, 2009;Tian et al, 2009;Catucci et al, 2010;Guo et al, 2010;Liu et al, 2010;Okubo et al, 2010;Pastrello et al, 2010;Srivastava et al, 2010;Xu et al, 2010;Zeng et al, 2010;Garcia et al, 2011;George et al, 2011;Akkiz et al, 2011;Hishida et al, 2011;Mittal et al, 2011;Permuth-Wey et al, 2011;Yue et al, 2011;Zhou et al, 2011;Zhou et al, 2012) with 11,901 cases and 14,200 controls were included in the present meta-analysis. An article by Catucci et al (2010) reported a case-control study of a German population and an Italian population separately, and one by Jazdzewski et al (2008) reported studies on populations of Finland, Poland, and USA separately.…”

Section: Selection Of Studiesmentioning

confidence: 99%

Meta-analysis confirms that a common G/C variant in the pre-miR-146a gene contributes to cancer susceptibility and that ethnicity, gender and smoking status are risk factors

Wang¹,

Xu²,

Tong³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. Evidence has shown that miR-146a is involved in carcinogenesis, and a common G/C variant (rs2910164) in the premiR-146a gene has been associated with various types of cancer. We summarized the data from 22 published case-control studies on the association between rs2910164 and cancer risk and performed subgroup analyses by ethnicity, gender and smoking status. We found a significant association between the pre-miR-146a polymorphism and cancer risk in Caucasian populations (odds ratio (OR) = 0.93, 95% confidence interval (CI) = 0.88-0.99 for G-vs C-allele), while the significance was borderline in Asian populations (OR = 1.11, 95%CI = 1.00-1.23 for G-vs C-allele). A significantly increased risk of cancer was found in males with GG/GC genotypes (OR = 1.23, 95%CI = 1.10-1.37), and the significance was more pronounced in smokers (OR = 1.82, 95%CI = 1.32-2.51) than in non-smokers (OR = 1.24, 95%CI = 1.01-1.53). We conclude that there is evidence that the pre-miR-146a polymorphism contributes to cancer susceptibilities and that gender and smoking status affect the probability of cancer in individuals with this polymorphism.

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Common genetic polymorphisms in pre‐microRNAs and risk of cervical squamous cell carcinoma

Cited by 83 publications

References 32 publications

Genetic and epigenetic factors in regulation of microRNA in colorectal cancers

Genetic and epigenetic factors in regulation of microRNA in colorectal cancers

Lack of Association between Hsa-Mir-499 rs3746444 Polymorphism and Cancer Risk: Meta-analysis Findings

Meta-analysis confirms that a common G/C variant in the pre-miR-146a gene contributes to cancer susceptibility and that ethnicity, gender and smoking status are risk factors

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