Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy

Zhou, Bin; Li, Rao; Peng, Ying; Wang, Yanyun; Chen, Yu; Song, Yaping; Zhang, Lin

doi:10.1016/j.cca.2010.05.010

Cited by 57 publications

(44 citation statements)

References 42 publications

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“…Xu et al [23] found that hsa-mir-196a2 rs11614913 CC was not only associated with a significantly increased risk of congenital heart disease but also associated with significantly increased mature miR-196a expression. Zhou et al [24] also demonstrated that significantly increased dilated cardiomyopathy risks were found to be associated with hsa-mir-196a2 rs11614913 CC genotype. Our hsa-mir-196a2 rs11614913 T ?…”

Section: Discussionmentioning

confidence: 94%

“…This SNP was also shown to affect the binding of mir-196a2 to its target mRNA and resulted in a significant increase in mature miR-196a2 levels with no changes in the precursor miRNA, suggesting that the mature miRNA is directly processed from the premiRNA [15]. More recent follow-up case-control studies, identified the two SNPs (rs11614913 and rs3746444) in hsamir-196a2 and hsa-mir-499 were associated with the increased risk for cancers [20][21][22], congenital heart disease [23] and dilated cardiomyopathy [24], so we hypothesized that SNPs in these miRNAs also may contribute to a susceptibility and unfavorable prognosis of CAD. To test this hypothesis, we genotyped and analyzed associations of two previously described common polymorphisms in pre-miRNAs [15] with the risk and prognosis of CAD in a Chinese population.…”

Section: Introductionmentioning

confidence: 95%

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Polymorphisms of miRNAs genes are associated with the risk and prognosis of coronary artery disease

Huang

Wang

et al. 2011

Clin Res Cardiol

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 95%

Polymorphisms of miRNAs genes are associated with the risk and prognosis of coronary artery disease

Huang

Wang

et al. 2011

Clin Res Cardiol

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“…11 Polymorphisms of pre-miRNAs were first reported in 2005 and since then several miRNA polymorphism-association studies have been reported. 12,13 Some pre-miRNA polymorphisms have negative effect on mature miRNA expression, 14,15 showing that premiRNA sequences are important for miRNA processing.…”

Section: Introductionmentioning

confidence: 99%

Recurrent Miscarriage and Micro-RNA Among North Indian Women

Parveen

Agrawal

2015

Reprod. Sci.

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Micro-RNAs (miRNAs) regulate diverse cellular processes such as cell differentiation, proliferation and apoptosis. Mutation in miRNAs results in various pathological conditions such as inflammation, viral infections, neurodegeneration, autoimmunity, and so on. We have evaluated the association of miR-146aC > G (rs2910164), miR-149T > C (rs2292832), miR-196a2T > C (rs11614913), and miR-499A > G (rs3746444) among patients with recurrent miscarriage (RM) and controls from North India. All the 200 patients with RM reported to experience at least 3 unexplained miscarriages before 20th week of gestation. Three hundred fertile women with no history of RMs were taken as controls. Both patients and controls were genotyped by the polymerase chain reaction amplification followed by restriction fragment length polymorphism. Variant alleles and genotypes of miR-499 A > G (Single Nucleotide Polymorphism Database [dbSNP] ID rs3746444) were found to be significant risks associated with patients having RM (odds ratio [OR] ¼ 1.98; 95% confidence interval [CI] ¼ 1.40-2.81; P value ¼ .0001) and controls (OR ¼ 3.64; 95% CI ¼ 1.33-9.94; P value ¼ .0109). A significant susceptible effect was found at allelic level in miR-196aT > C (dbSNP ID rs11614913) and miR-499 A > G (dbSNP ID rs3746444).

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“…Levels of α-heavy chain myosin messenger RNA were lower in DCM patients, whereas the β-heavy chains levels were higher and were associated with greater volumes of collagen in the myocardium (SATOH et al, 2010). In other research, ZHOU et al (2010) observed a significant increase in the risk of dilated cardiomyopathy in people with overexpression of some pre-microRNAs, as a consequence of common polymorphism of a single nucleotide, including miR196a2 and HSA-miR-499, which influenced several genes with different functions.…”

Section: Cardiomyopathies In Dogsmentioning

confidence: 74%

MicroRNAs in veterinary cardiology

2017

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The use of biomarkers is an important recent development in veterinary medicine. Biomarkers allow non-invasive quantification of substances with diagnostic and prognostic potential in several diseases. The microRNAs are small, non-coding RNAs that regulate gene expression and are expressed in different forms in many diseases. Reduced or over-expression of microRNAs showed to be part of the pathogenesis of some heart diseases in humans and animals. Diagnostic and therapeutic value of measuring microRNAs in veterinary cardiology is increased because abnormal expression can be managed by the use of antagonists (in the case of overexpression) and mimicking (in the case of underexpression). Thus, this literature review aimed to compile scientific evidence of dysregulation of microRNAs expression in different cardiac diseases being one of the promises in the therapeutic field and diagnosis of veterinary cardiology. MicroRNAs not only have potential as a biomarker but may also help in elucidation of aspects of the pathogenesis of a variety of diseases.

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Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy

Cited by 57 publications

References 42 publications

Polymorphisms of miRNAs genes are associated with the risk and prognosis of coronary artery disease

Polymorphisms of miRNAs genes are associated with the risk and prognosis of coronary artery disease

Recurrent Miscarriage and Micro-RNA Among North Indian Women

MicroRNAs in veterinary cardiology

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