Common genetic markers and prediction of recurrent events after ischemic stroke in young adults

Abstract

Addition of common genetic variants to traditional risk factors may be an effective method for discriminating young stroke patients at different risk of future ischemic events.

The Role of Classic Risk Factors and Prothrombotic Factor Gene Mutations in Ischemic Stroke Risk Development in Young and Middle-Aged Individuals

“…A very similar profile of classic vascular risk factors in young ischemic stroke patients has also been reported elsewhere, however, differing in the order of frequency [3][4][5][6][7][15][16][17][18][19]. These results show that conventional vascular risk factors are significant risk factors for ischemic stroke not only in the >55 age group, but also in younger population.…”

“…Research results suggest that the genetic predisposition might primarily influence the etiopathogenesis of premature ischemic stroke in young and middle-aged individuals [6][7][8].…”

“…Among them, the G20210A polymorphism of the prothrombin gene, the G1691A polymorphism of the factor V gene, the C677T polymorphism of the methylentetrahydrofolate reductase (MTHDR) gene and the 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) are the most frequently studied. Some studies failed, but others did demonstrate the association of these polymorphisms with the risk of ischemic stroke [6][7][8][9][10][11][12]. Results from these studies address the weak effect of single genetic marker on the stroke risk development; it might be stronger in younger individuals and in mutually cumulative interactions of different polymorphisms.…”

Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack

“…676 For patients with 1 mutation, the OR was 2.01 (95% CI, 1.38-2.93), and for patients with 2 mutations, the OR was 4.05 (95% CI, 1. 91-8.57).…”

How Does Number of Risk Factors Affect Prognosis in Young Patients With Ischemic Stroke?

“…4 However, it remains poorly studied how patients stratified by burden of risk factors differ from each other and whether number of risk factors could serve as an independent indicator of better or worse prognosis when accounting for demographic factors and stroke subtype. 5 We studied how the young patient with ischemic stroke free of well-documented risk factors 6 differs-in terms of demographics, clinical stroke features, underlying etiology, and long-term outcome-from those having at least 1 risk factor. We investigated further what number of these vascular risk factors and additive information from less welldocumented risk factors would add on prognostic models regarding functional outcome, recurrent ischemic stroke, new cardiovascular events, or death from any cause.…”