Common gene polymorphisms, cancer progression and prognosis

Loktionov, Alexandre

doi:10.1016/j.canlet.2004.02.009

Cited by 91 publications

(62 citation statements)

References 146 publications

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“…Furthermore, the presence of C homozygous allele for TP53 gene also increases by more than three times the susceptibility to s-MTC. Cell cycle and apoptosis regulators directly involved in the initiation of malignant cell proliferation have long been preferred targets as cancer risk markers (19). The Pro allele was also associated with an increased risk of differentiated thyroid cancer in previous reports (10).…”

Section: Discussionmentioning

confidence: 98%

Evidence that polymorphisms in detoxification genes modulate the susceptibility for sporadic medullary thyroid carcinoma

Barbieri

Bufalo

Secolin

et al. 2012

European Journal of Endocrinology

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Aim: Polymorphic low-penetrance genes have been consistently associated with the susceptibility to a series of human tumors, including differentiated thyroid cancer. Methods: To determine their role in medullary thyroid cancer (MTC), we used TaqMan SNP method to genotype 47 sporadic MTC (s-MTC) and a control group of 578 healthy individuals for CYP1A2*F, CYP1A1m1, GSTP1, NAT2 and 72TP53. A logistic regression analysis showed that NAT2C/C (ORZ3.87; 95% CIZ2.11-7.10; PZ2.2!10 K5) and TP53C/C genotypes (ORZ3.87; 95% CIZ1.78-6.10; PZ2.8!10 K4) inheritance increased the risk of s-MTC. A stepwise regression analysis indicated that TP53C/C genotype contributes with 8.07% of the s-MTC risk. Results: We were unable to identify any relationship between NAT2 and TP53 polymorphisms suggesting they are independent factors of risk to s-MTC. In addition, there was no association between the investigated genes and clinical or pathological features of aggressiveness of the tumors or the outcome of MTC patients. Conclusion:In conclusion, we demonstrated that detoxification genes and apoptotic and cell cycle control genes are involved in the susceptibility of s-MTC and may modulate the susceptibility to the disease.

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Section: Discussionmentioning

confidence: 98%

Evidence that polymorphisms in detoxification genes modulate the susceptibility for sporadic medullary thyroid carcinoma

Barbieri

Bufalo

Secolin

et al. 2012

European Journal of Endocrinology

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“…Many studies in humans have provided evidence that the presence of single nucleotide polymorphisms (SNPs) in miRNAs can alter miRNA processing, expression, and/or binding to target mRNAs, thereby representing another type of genetic variability that can contribute to susceptibility to cancer development (Zeng and Cullen, 2003;Loktionov, 2004;Duan et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

An A/G polymorphism rs3746444 in miR-499 is associated with increased cancer risk: a meta-analysis

Wang¹,

Tian²,

Li³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. An A/G polymorphism (rs3746444) has been identified in the miR-499 gene that can change the conformation of the secondary gene structure and thereby directly affect binding to target mRNAs and the microRNA (miRNA) maturation process, thus altering protein expression and potentially contributing to cancer susceptibility. Numerous studies investigating the association between the rs3746444 polymorphism and cancers have been published; however, results are inconsistent and inconclusive. To clarify the relationship between the miR-499 rs3746444 polymorphism and cancer, we conducted a comprehensive meta-analysis on 14 case-control studies comprising 7189 cases and 8577 controls. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by using dominant, recessive, and co-dominant genetic models. A publication bias test and subgroup analysis were also performed. Results showed that the G allele was associated with a significantly increased cancer risk compared to the A allele (OR = 1.09; 95%CI = 1.00-1.18). Similarly, moderately elevated risks were also observed in overall analyses in the dominant model (OR = 1.13; 95%CI = 1.01-1.26). Moreover, significantly increased risks were observed in Asian populations (G allele vs A allele: OR = 1.18; 95%CI = 1.01-1.37; GG vs AA: OR = 1.36; 95%CI = 1.07-1.73; dominant model: OR = 1.19; 95%CI = 1.00-1.41; recessive model: OR = 1.31; 95%CI = 1.03-1.66), but not in European populations. These findings indicate that the miR-499 rs3746444 polymorphism is associated with an increased cancer risk.

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“…But, many researchers suggest that larger studies will be needed also to investigate the effect of specific treatment modalities in cancer. While investigating the post-initiation stages of cancer, four basic parts can be dedicated to gene polymorphisms affecting: (a)growth control of cell (cell proliferation, differentiation and death); (b)factors involved in tumour invasion and metastasis (immune and inflammatory responses, extracellular matrix remodelling, angiogenesis and cell adhesion); (c)effects of hormones and vitamins on growing tumours; (d)outcome of cancer therapy (cancer pharmacogenetics) (Loktionov, 2004). Quantitation of gene expression in tumor or host cells has another an enormous importance for investigating the gene patterns responsible for cancer development, progression and response or resistance to therapy.…”

Section: Pcr-based Studies In Cancer Researchmentioning

confidence: 99%