Common fragile sites in chromosomes of bone marrow cells and peripheral blood lymphocytes from healthy persons and leukemia patients

Furuya, Takashi; Ochi, Hisako; Watanabe, Shaw

doi:10.1016/0165-4608(89)90136-2

Cited by 14 publications

(9 citation statements)

References 15 publications

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“…Furuya et al (1989) described a CFS that accounts for 13.4% of the total BCG scored in human bone marrow cells of healthy persons at 4q21-25 (the most expressed in these cells). Recurrent BCG were also localized at 4q21 or 4q23 in other types of cells (Murano et al, 1989;Caporossi et al, 1995;Gericke et al, 1996;Simonic et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer

et al. 2004

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Fragile sites are classified as common or rare depending on their occurrence in the populations. While rare sites are mainly associated with inherited diseases, common sites have been involved in somatic rearrangements found in the chromosomes of cancer cells. Here we study a mouse locus containing the ionotropic glutamate receptor delta 2 (grid2) gene in which spontaneous chromosome rearrangements occur frequently, giving rise to mutant animals in inbred populations. We identify and clone common fragile sites overlapping the mouse grid2 gene and its human ortholog GRID2, lying respectively at bands 6C1 and 4q22 in a 7-Mb-long region of synteny. These results show a third example of orthologous common sites conserved at the molecular level, and reveal an unexpected link between an inherited disease and an aphidicolin-sensitive region. Recurrent deletions of subregions of band 4q22 have been previously described in human hepatocellular carcinomas. This 15-Mb-long region appears precisely centered on the site described here, which strongly suggests that it also plays a specific role in hepatic carcinogenesis.

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Section: Discussionmentioning

confidence: 99%

Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer

et al. 2004

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“…8q22 is a common site of chromosome fragility (Furuya et al, 1989). The translocation t(8 : 21) (q22;q22) is a typical chromosomal abnormality associated with acute myeloid leukemia (Rabbitts, 1994).…”

Section: Discussionmentioning

confidence: 99%

Cloning and characterization of a novel gene encoding a putative transmembrane protein with altered expression in some human transformed and tumor-derived cell lines

Jiang¹,

Wang²,

Maher³

et al. 1999

Oncogene

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“…Evidence, both positive (Tedeschi et aI., 1987;Furuya et al, 1989) and negative (Rao et al, 1988;Green et al, 1988;Porfirio et al, 1989;Kampmann et al, 1990), with respect to association of the expressivity of common fragile site with cancer has been reported with but a small number of subjects. In the present study, we tested the expression of fra(3)(pl4.2) in a large number of unselected hospital patients, including cancers of the various organs.…”

Section: Discussionmentioning

confidence: 99%

“…The present study con-ducted a similar survey on patients of various diseases. Whereas there have been a few papers which showed a positive correlation with some cancers (Tedeschi et al, 1987;Furuya et al, 1989), the common fragile sites are not generally considered as having any biological significance.…”

Section: Introductionmentioning

confidence: 99%

Expressivity of a common fragile site, fra(3)(p14.2), in patients with cancer and other diseases

et al. 1992

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SummaryA population survey of a common folate-sensitive fragile site, fra(3)(pl4.2), has been carried out on PHA-stimulated peripheral lymphocytes of patients with cancer and other diseases, under both culture conditions of folate deprivation and aphidicolin treatment. Overall findings regarding variability of expressivity due to age and sex were very similar to those obtained in a healthy population. The expression of fra(3)(pl4.2) by folate deficient condition appeared hardly influenced by such exogenous factors as tobacco smoking habit, past histories of radiotherapy and chemotherapy, while it was associated with the unfavorable prognosis of cancers. Furthermore, proportion of those with higher expression was slightly but significantly larger in both lung and breast cancer patients. These findings suggest that some factors relevant to the expression of fra(3)(pl4.2) may be associated with development and progression of certain kinds of cancer.

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Common fragile sites in chromosomes of bone marrow cells and peripheral blood lymphocytes from healthy persons and leukemia patients

Cited by 14 publications

References 15 publications

Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer

Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer

Cloning and characterization of a novel gene encoding a putative transmembrane protein with altered expression in some human transformed and tumor-derived cell lines

Expressivity of a common fragile site, fra(3)(p14.2), in patients with cancer and other diseases

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