Common fragile site expression and genetic predisposition to breast cancer

Çeçener, Gülşah; Egelí, Ünal; Taşdelen, İsmet; Tunca, Berrin; Duman, Hakan; Kizil, Ayhan

doi:10.1002/(sici)1520-6866(1998)18:6<279::aid-tcm2>3.0.co;2-u

Cited by 18 publications

(4 citation statements)

References 20 publications

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“…For this reason, their baseline DNA damage was higher than in healthy participants. Other investigators also reported the probability that the neoplastic disease itself is associated with increased DNA damage, as well as that cancer patients have a more fragile DNA than healthy individuals (24,25). The background levels of DNA damage in leukocytes are mostly influenced by reactive oxygen species that are continuously generated under physiological conditions as an outcome of cellular metabolism, personal life-style, age, and daily environmental exposure to different mutagens (26).…”

Section: Discussionmentioning

confidence: 99%

Genome Damage in Oropharyngeal Cancer Patients Treated by Radiotherapy

Gamulin

Kopjar²,

Grgić³

et al. 2008

Croat Med J

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Oropharyngeal cancer patients had relatively high levels of primary DNA damage in their peripheral blood lymphocytes even before therapy. The frequency of complex structural chromosome aberrations and the frequency of micronuclei increased with the progression of the radiation cycle and the doses delivered. As the frequency of chromosomal aberrations a year after radiotherapy mostly did not return to pre-therapy values, it represents an important risk factor related to the onset of second cancer.

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Section: Discussionmentioning

confidence: 99%

Genome Damage in Oropharyngeal Cancer Patients Treated by Radiotherapy

Gamulin

Kopjar²,

Grgić³

et al. 2008

Croat Med J

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“…We observed, especially, more frequent fragile sites in FRA3B. Expression of the FRA3B-localized FHIT tumor suppressor gene was observed at very high levels in breast cancer patients and their relatives compared with controls 3 .…”

Section: Introductionmentioning

confidence: 62%

Importance of Novel Sequence Alterations in the FHIT Gene on Formation of Breast Cancer

Çeçener

Egelí

Tunca

et al. 2007

Tumori

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“…DNA-repair ability among cancer patients, the probability is that the neoplastic disease itself is associated with increased DNA damage or that these patients have a more fragile DNA than healthy individuals (Çeçener et al, 1998;Kopjar et al, 2006;Ursini et al, 2006).…”

Section: Table )2(: Comet Assay Results For Patients and Controlmentioning

confidence: 99%