Common electrocardiogram measures are not associated with telomere length

Abstract

Aims: Aging is accompanied by telomere shortening. Increased telomere shortening is considered a marker of premature aging. Cardiac aging results in the development of cardiac pathologies. Electrocardiogram (ECG) measures reflect cardiac excitation, conduction, and repolarization. ECG measures also prolong with aging and are associated with cardiac pathologies including atrial fibrillation. As premature prolongation of ECG measures is observed, we hypothesized that such prolongation may be associated with telomere length. Methods and Results: We studied the large, community-based KORA F4 Study. Of 3,080 participants enrolled between 2006 and 2007 with detailed information on demographic, anthropometric, clinical, and ECG characteristics, 2,575 presented with available data on leukocyte telomere length. Telomere length was determined by real-time quantitative PCR and expressed relative to a single copy gene. We fitted multivariable adjusted linear regression models to associate the ECG measures RR-interval, PR-interval, QRS-duration, and heart rate corrected QTc with telomere length. In our cohort, the mean age was 54.9±12.9 years and 46.6% were men. Increased age was associated with shorter telomere length (p<0.01), and men had shorter telomere length than women (p<0.05). In unadjusted models, heart rate (p=0.023), PR-interval (p<0.01), and QTc-interval (p<0.01) were significantly associated with shorter telomere length. However, no significant associations remained after accounting for age, sex, and covariates. Conclusions: ECG measures are age-dependent, but not associated with shortened telomere length as a marker of biological aging. Further research is warranted to clarify if shortened telomeres are associated with clinical cardiac pathologies including atrial fibrillation.

DNA Methylation and Telomeres—Their Impact on the Occurrence of Atrial Fibrillation during Cardiac Aging

“…This relates to younger people's greater exposure to occupational hazards, stress, or higher alcohol consumption [108][109][110]. In addition, when analyzing studies of cardiac electrical activity, there is no correlation between electrocardiographic features on the ECG and rTL [111]. However, those with a history of AF were significantly older than those free of arrhythmia and had shorter telomeres [62,[111][112][113].…”

“…In addition, when analyzing studies of cardiac electrical activity, there is no correlation between electrocardiographic features on the ECG and rTL [111]. However, those with a history of AF were significantly older than those free of arrhythmia and had shorter telomeres [62,[111][112][113]. Therefore, to show a trend between the association of AF and rTL, age stratification is used (the entire study group was divided into quartiles-Q1-Q4) [112].…”