Common Drug Pathways and Interactions

Kroner, Beverly A.

doi:10.2337/diaspect.15.4.249

Cited by 12 publications

(8 citation statements)

References 39 publications

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“…Fluconazole, a CYP3A enzyme inhibitor, causes inhibition of amlodipine metabolism leading to increased risk of hypotension. [ 18 ] ACE inhibitors administered along with the sulfonylureas may increase the insulin sensitivity through vasodilatation and potentiate the risk of hypoglycemia. [ 19 ]…”

Section: Discussionmentioning

confidence: 99%

Study of drug–Drug interactions among the hypertensive patients in a tertiary care teaching hospital

2018

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Aim:Drug–drug interactions (DDIs) are one of the major but preventable cause of adverse drug reaction. Study of prevalence and prediction of DDIs will make the physician easier to provide better patient care and mitigate patient's harm. Hence, the study was planned to evaluate the potential DDIs among medication prescribed to hypertensive patients in our hospital.Materials and Methods:A prospective, cross-sectional study was conducted among the hypertensive patients in medicine (outpatient/inpatient) department over the period of three months in a tertiary care hospital. Adult hypertensive patients of either sex with comorbidities were included in the study. The prescriptions were collected and analyzed for DDI using Medscape interaction checker. Data were analyzed using SPSS (version 16.0) software and expressed in percentage. Pearson's correlation and regression analysis were done.Results:Among 125 patients, 48% were exposed to at least one DDI. Totally 123 DDI were identified and majority of them were significant (85.36%). No serious interactions were identified. Pharmacodynamic and pharmacokinetic drug interactions were found to be 37.39% and 28.76%, respectively. Logistic regression analysis showed advanced male gender and polypharmacy was associated with increased risk of DDI. About 51 interacting pairs of DDI were identified and most frequently occurring pair was amlodipine with atenolol. Aspirin was found to have commonly involved in DDI with enalapril, atenolol, frusemide, spironolactone, carvedilol, and metoprolol.Conclusion:The study highlighted that patients with hypertension are particularly vulnerable to DDI. The comorbidities, advanced age, and polypharmacy are the important factors associated with the occurrence of DDI.

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Section: Discussionmentioning

confidence: 99%

Study of drug–Drug interactions among the hypertensive patients in a tertiary care teaching hospital

2018

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“…Poucas IMP encontradas eram farmacocinéticas, corroborando assim com os dados encontrados na literatura que demonstram que interações farmacocinéticas são menos frequentes em pacientes que usam medicamentos para tratamento da DM, já que esses geralmente não são substratos, indutores ou inibidores de enzimas frequentemente envolvidas no metabolismo de medicamentos (29,30). Em populações ditas gerais, esse tipo de interação é mais frequente, como evidenciado por Leão e cols.…”

Section: Discussionunclassified

“…Ainda no contexto das IMP risco C, vale ressaltar a considerável frequência de interações envolvendo beta -bloqueadores e ADO, especialmente as sulfonilureias. Estudos demonstram o benefício dos beta-bloqueadores em diabéticos, mas recomendam evitar os agentes não cardiosseletivos, como o propranolol, pois podem mascarar sinais fisiológicos importantes dos estados hipoglicêmicos, como a taquicardia (29,34). Apesar da frequência de IMP risco C ter sido 11 vezes maior do que as de risco D, cuja frequência foi semelhante à encontrada por Amaral & Perassolo (2012) (31), vale considerar a importância dessa última, devido as suas potenciais consequências clínicas que estão associadas ao aumento do risco de reações adversas (11).…”

Section: Discussionunclassified

Interações Medicamentosas Potenciais Em Diabéticos Tipo 2 Participantes De Um Programa De Educação Em Saúde

Lima

Machado²,

Rebelo³

et al. 2015

Infarma

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Estudo transversal com objetivo de identificar frequência, impacto clínico e fatores associados a Interações Medicamentosas Potenciais (IMP) em portadores de diabetes mellitus tipo 2 (DM2) participantes de um programa de educação em saúde. O estudo envolveu 71 diabéticos e as IMP foram classificadas utilizando a base UpToDate®. Os participantes com e sem IMP foram comparados considerando variáveis sócio-demográficas e clínicas através dos testes qui-quadrado e t student. Foram utilizados 4,6 medicamentos em média e mais de 70% apresentaram alguma IMP (total de 140 interações). Mais de 70% requeriam monitoramento da farmacoterapia e em 6,4% havia necessidade de considerar alteração da prescrição. As IMP aumentaram conforme número de medicamentos prescritos (p<0,001) e não variou quanto ao gênero, idade e tempo de diagnóstico.

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“…Significant drug interactions and patient harm that results from them are common concerns in clinical practice. One study showed that although drug interactions account for only 3.8% of emergency room visits, the patients affected by them usually have to be admitted to the hospital 15 . However it is not only the drug-drug interactions; the drugdisease interactions are also very common in diabetics 16 .…”

Section: Discussionmentioning

confidence: 99%

An Experimental Study of Drug Interactions of Diclofenac with Commonly Used Drugs for Diabetes Mellitus in Rabbits

Yadav

Sharma

Puri

et al. 2013

IJMDS

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Common Drug Pathways and Interactions

Cited by 12 publications

References 39 publications

Study of drug–Drug interactions among the hypertensive patients in a tertiary care teaching hospital

Study of drug–Drug interactions among the hypertensive patients in a tertiary care teaching hospital

Interações Medicamentosas Potenciais Em Diabéticos Tipo 2 Participantes De Um Programa De Educação Em Saúde

An Experimental Study of Drug Interactions of Diclofenac with Commonly Used Drugs for Diabetes Mellitus in Rabbits

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