Common data elements (CDEs) for preclinical epilepsy research: Introduction to CDEs and description of core CDEs. A TASK3 report of the ILAE/AES joint translational task force

Harte‐Hargrove, Lauren C.; Galanopoulou, Aristea S.; French, Jacqueline; Pitkänen, Asla; Whittemore, Vicky; Scharfman, Helen E.

doi:10.1002/epi4.12234

Cited by 24 publications

(35 citation statements)

References 42 publications

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“…Table provides a nonexhaustive list of preclinical Common Data Elements (CDEs) for reporting general experimental settings, common to all neurobehavioral tests. These CDEs are invariably used in conjunction with Core CDEs, which include individual animal data (e.g., species, strain, date of birth, sex, and source), and on demand, with other relevant CDEs (e.g., Pharmacology, Physiology, and EEG), depending on the experimental goals.…”

Section: General Experimental Settingsmentioning

confidence: 99%

A companion to the preclinical common data elements on neurobehavioral comorbidities of epilepsy: a report of the TASK3 behavior working group of the ILAE/AES Joint Translational Task Force

et al. 2018

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SummaryThe provided companion has been developed by the Behavioral Working Group of the Joint Translational Task Force of the International League Against Epilepsy (ILAE) and the American Epilepsy Society (AES) with the purpose of assisting the implementation of Preclinical Common Data Elements (CDE) for studying and for reporting neurobehavioral comorbidities in rodent models of epilepsy. Case Report Forms (CRFs) are provided, which should be completed on a per animal/per test basis, whereas the CDEs are a compiled list of the elements that should be reported. This companion is not designed as a list of recommendations, or guidelines for how the tests should be run—rather, it describes the different types of assessments, and highlights the importance of rigorous data collection and transparency in this regard. The tests are divided into 7 categories for examining behavioral dysfunction on the syndrome level: deficits in learning and memory; depression; anxiety; autism; attention deficit/hyperactivity disorder; psychosis; and aggression. Correspondence and integration of these categories into the National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) is introduced. Developmental aspects are addressed through the introduction of developmental milestones. Discussion includes complexities, limitations, and biases associated with neurobehavioral testing, especially when performed in animals with epilepsy, as well as the importance of rigorous data collection and of transparent reporting. This represents, to our knowledge, the first such resource dedicated to preclinical CDEs for behavioral testing of rodents.

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Section: General Experimental Settingsmentioning

confidence: 99%

A companion to the preclinical common data elements on neurobehavioral comorbidities of epilepsy: a report of the TASK3 behavior working group of the ILAE/AES Joint Translational Task Force

et al. 2018

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“…For other information except EEG recording and scoring, such as rodent species, animal characteristics, model type, physiologic monitoring, pharmacologic study design, and behavioral scoring other than seizures, the TASK3 group has created separate sets of CDEs and CRFs that investigators may use as needed based on the study design. For example, to describe the animal characteristics, one may use the core CDEs …”

Section: Structure Of Cde Charts/crf Modules For Eeg Studiesmentioning

confidence: 99%

A companion to the preclinical common data elements and case report forms for rodent EEG studies. A report of the TASK3 EEG Working Group of the ILAE/AES Joint Translational Task Force

et al. 2018

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SummaryElectroencephalography (EEG) is commonly used in epilepsy and neuroscience research to study brain activity. The principles of EEG recording such as signal acquisition, digitization, and conditioning share similarities between animal and clinical EEG systems. In contrast, preclinical EEG studies demonstrate more variability and diversity than clinical studies in the types and locations of EEG electrodes, methods of data analysis, and scoring of EEG patterns and associated behaviors. The TASK3 EEG working group of the International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force has developed a set of preclinical common data elements (CDEs) and case report forms (CRFs) for recording, analysis, and scoring of animal EEG studies. This companion document accompanies the first set of proposed preclinical EEG CRFs and is intended to clarify the CDEs included in these worksheets. We provide 7 CRF and accompanying CDE modules for use by the research community, covering video acquisition, electrode information, experimental scheduling, and scoring of EEG activity. For ease of use, all data elements and input ranges are defined in supporting Excel charts (Appendix S1).

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“… Core CDEs: Harte‐Hargrove et al . Common Data Elements (CDEs) for Preclinical Epilepsy Research: Introduction to the Special Issue and Description of Core CDEs.…”

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confidence: 99%

“…The Core CDEs refer to data that are collected for virtually all experiments in preclinical epilepsy. In contrast, for any given study, the CDEs for Behavior, for example, may not be used because behavioral assays might not be part of the specific study.…”

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Preclinical common data elements (CDEs) for epilepsy: A joint ILAE/AES and NINDS translational initiative

et al. 2018

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Common data elements (CDEs) for preclinical epilepsy research: Introduction to CDEs and description of core CDEs. A TASK3 report of the ILAE/AES joint translational task force

Cited by 24 publications

References 42 publications

A companion to the preclinical common data elements on neurobehavioral comorbidities of epilepsy: a report of the TASK3 behavior working group of the ILAE/AES Joint Translational Task Force

A companion to the preclinical common data elements on neurobehavioral comorbidities of epilepsy: a report of the TASK3 behavior working group of the ILAE/AES Joint Translational Task Force

A companion to the preclinical common data elements and case report forms for rodent EEG studies. A report of the TASK3 EEG Working Group of the ILAE/AES Joint Translational Task Force

Preclinical common data elements (CDEs) for epilepsy: A joint ILAE/AES and NINDS translational initiative

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