Common connections among identified cells in the central ganglia of the snail, Helix

Judge, Susan E.; Kerkut, G.A.; Walker, Robert

doi:10.1016/0300-9629(76)90140-7

Cited by 11 publications

(3 citation statements)

References 15 publications

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“…The outer connective tissue sheath was dissected away with fine forceps to expose the cell bodies. Cells D1 and D2 in the left parietal ganglion were used for this study (Judge, Kerkut & Walker, 1976). The preparation was then placed in a 'Perspex bath' (volume 2 ml) where it was perfused continuously at a constant rate of 60 ml/h with Ringer solution (composition mM: NaCl 80, KCl 4, CaCl2 8, MgCl2 5 and Tris buffer 5; pH = 7.8).…”

Section: Specimens Of Helix Aspersa (From Gerrard and Haigmentioning

confidence: 99%

“…Sodium thiopentone (May & Baker Ltd), etomidate (Janssen), minaxolone (Glax4 ketamine hydrochloride (Parke-Davis) were Results Cells Dl and D2 are large, silent neurones in the caudal region of the left parietal ganglion of Helix aspersa (Judge et al, 1976). Iontophoretic application of ACh (20-100 nA current, is duration) evoked inhibitory responses in the cells.…”

Section: Methodsmentioning

confidence: 99%

“…The outer connective tissue sheath was dissected away with fine forceps to expose the cell bodies. Cells D1 and D2 in the left parietal ganglion were used for this study (Judge, Kerkut & Walker, 1976 Acetylcholine (ACh) was applied iontophoretically (20-100 nA; 1 s) onto the cells through a microelectrode containing a 1 M solution of ACh bromide (pH 5) using a microiontophoresis programmer (WP Instruments). Application was programmed using a Digitimer (D4050).…”

Section: Methodsmentioning

confidence: 99%

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THE ACTION OF GENERAL ANAESTHETICS ON ACETYLCHOLINE‐INDUCED INHIBITION IN THE CENTRAL NERVOUS SYSTEM OF Helix

Judge

Norman

1982

British J Pharmacology

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1 The effects of general anaesthetics, thiopentone, etomidate, minaxolone and ketamine were studied on identified voltage-clamped neurones of Helix aspersa. 2 At concentrations of 0.1-0.5 mM, thiopentone, etomidate and minaxolone had no effect on the resting conductance of identified cells, D1 and D2. Ketamine at a concentration of 0.1-0.5 mM depolarized and excited the cells. 3 All four anaesthetics tested depressed a chloride-dependent inhibitory response to acetylcholine (ACh) in cells D1 and D2 at concentrations of 0. 1-0.5 mM in a dose-dependent and reversible manner with no change in the reversal potential of the response. 4 These results show that general anaesthetics can block the transmitter-evoked chloridemediated increases in membrane conductance in Helix neurones.

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Section: Specimens Of Helix Aspersa (From Gerrard and Haigmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The outer connective tissue sheath was dissected away with fine forceps to expose the cell bodies. Cells D1 and D2 in the left parietal ganglion were used for this study (Judge, Kerkut & Walker, 1976 Acetylcholine (ACh) was applied iontophoretically (20-100 nA; 1 s) onto the cells through a microelectrode containing a 1 M solution of ACh bromide (pH 5) using a microiontophoresis programmer (WP Instruments). Application was programmed using a Digitimer (D4050).…”

Section: Methodsmentioning

confidence: 99%

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