Common causes of false positive F18 FDG PET/CT scans in oncology

Carter, Kevin R.; Kotlyarov, Eduard V.

doi:10.1590/s1516-89132007000600004

Cited by 33 publications

(28 citation statements)

References 13 publications

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“…PET-CT is known to be less specific as inflammatory cells will also cause increased FDG avidity, most commonly in the context of infection. However, increased uptake has also been reported in postischemic or infarcted tissue [27][28][29], atherosclerosis [30], physiological papillary muscle [31], hypertrophied papillary muscle [32], and postoperative contexts [32]. To our knowledge, there are no reported cases of chronic mitral regurgitation due to prolapse being a cause of increased FDG avidity.…”

Section: Discussionmentioning

confidence: 89%

A Multimodal Approach to Evaluate for Cardiac Metastasis in a Case of Non-Small Cell Lung Cancer

et al. 2020

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Malignancies have demonstrated the ability to metastasize to cardiac tissue. However, an optimal diagnostic algorithm for cardiac tumors has not yet been established, due at least in part to the scarcity of symptomatic cases. Several case reports describe how the usage of 18 F-labeled fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) incidentally revealed cardiac neoplasia. This modality, which indicates uptake sites of the radioisotope 18 F-FDG, allows for whole-body imaging and is often used for preoperative determination of malignant metastasis or for assessing response to therapy over time. However, findings of false positivity are often reported due to increased FDG avidity caused by a range of other, nonmetastatic processes, most notably inflammation and infection. In this case report, an 84-year-old male with stage IV non-small cell lung cancer presented a clinical course, echocardiogram, and 18 F-FDG PET-CT findings that were suggestive of endocardial metastasis. Nine months into therapy, after extensive consultation, the patient finally consented to a more complete workup using cardiac MRI (CMRI), which showed no evidence of cardiac metastasis. This case report supports the utility of CMRI as a means of further interpreting intracardiac, localized FDG uptake foci in PET-CT findings, in order to avoid false positivity and further refine proposed cardiac differential diagnoses in cancer patients.

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Section: Discussionmentioning

confidence: 89%

A Multimodal Approach to Evaluate for Cardiac Metastasis in a Case of Non-Small Cell Lung Cancer

et al. 2020

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“…These conditions include noninfectious inflammatory granulomatous processes and disseminated inflammatory processes like, sarcoidosis, atherosclerosis, and pneumoconiosis, diffuse muscular uptake following administration of insulin and diffuse increased bone uptake following the administration of colony stimulating factors prior to the injection of FDG, prior biopsies, sites of catheter insertions, and sites of other drainage tube insertions, radiation therapy induced pneumonitis/fibrosis, as well as talc pleurodesis, benign tumors such as fibrous mesothelioma, schwannoma, aggressive neurofibromas and enchondromas and metallic or otherwise dense foreign bodies on the surface of the body or implanted (pace-maker, stimulators, leads, prosthetics, bullet fragments, brachytherapy) bodies. 29,30 In addition, 18 F FDG PET/CT scan include high radiation doses, relatively high cost and limited availability. Considering these limitations, the future research should identify at which stage of FUO work up, 18 F FDG PET/CT scan should be used.…”

Section: Discussionmentioning

confidence: 99%

Utility of 18 F‐FDG PET/CT scan to diagnose the etiology of fever of unknown origin in patients on dialysis

Chand

Chennu

Yadagiri

et al. 2016

Hemodialysis International

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“…Images of metabolic activity in space are then reconstructed by computer analysis, often in modern scanners, alowing to visualize the radiotracer distribution in the body, and subtle changes in physiological performance in vivo (Ribeiro et al, 2007). PET is common imaging modality for clinical use in oncology and in many neurological diseases (Wiebe, 2007;Carter and Kotlyarov, 2007;Lomena and Soler, 2005). A new application for the nuclear imaging techniques is the study of psychological and physiological responses to stress.…”

Section: Introductionmentioning

confidence: 99%

Psycological and physiological responses to stress: a review based on results from PET and MRI studies

Cortez

Cruz

Silva

2008

Braz. arch. biol. technol.

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A new application for the nuclear imaging techniques is the study of organic responses to stress. Neuroimaging techniques allow the assessment of brain activation changes in association with the metabolic responses to stress. In this paper, a review of general effects of the stress on organic activity is made, emphasizing important advances introduced by studies using PET and fMRI. The importance of the hypothalamus-pituitary-adrenal axis to onset the adequate psychical and organic responses to sustain the homeostasis during the stress is discussed, as well as the possibility of traumatic stressing experiences have negative effects on the brain.

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Common causes of false positive F18 FDG PET/CT scans in oncology

Abstract: PET/CT is a common imaging modality used in the evaluation

Cited by 33 publications

References 13 publications

A Multimodal Approach to Evaluate for Cardiac Metastasis in a Case of Non-Small Cell Lung Cancer

A Multimodal Approach to Evaluate for Cardiac Metastasis in a Case of Non-Small Cell Lung Cancer

Utility of 18 F‐FDG PET/CT scan to diagnose the etiology of fever of unknown origin in patients on dialysis

Psycological and physiological responses to stress: a review based on results from PET and MRI studies

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