Common carotid intima-media thickness in patients with peripheral arterial disease or abdominal aortic aneurysm: the SMART study

Simons, Petra C. G.; Algra, Ale; Bots, Michiel L.; Jd, Banga; Grobbee, Diederick E.; Graaf, Yolanda van der

doi:10.1016/s0021-9150(99)00142-2

Cited by 38 publications

(26 citation statements)

References 40 publications

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“…Despite such heterogeneity between these observational cross -sectional studies, one can fairly say that AAA prevalence among CAD patients exceeds that observed in population -based studies. It is also of interest that the prevalence of AAA in CAD patients was comparable to that reported in AAA screening studies of patients with peripheral vascular disease (7% -17%) and cerebrovascular disease (8.4% -20.2%) (Bentgsson et al, 1996;Kurvers et al, 2003;Palazzuoli et al, 2008;Simons et al, 1999).…”

Section: High Heterogeneity Of Studiesmentioning

confidence: 59%

Abdominal Aortic Aneurysm in Patients with Coronary Artery Disease: A Review Article

Elkalioubie¹,

Jude²,

Dupont³

2011

Diagnosis and Treatment of Abdominal and Thoracic Aortic Aneurysms Including the Ascending Aorta and the Aortic Arch

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Section: High Heterogeneity Of Studiesmentioning

confidence: 59%

Abdominal Aortic Aneurysm in Patients with Coronary Artery Disease: A Review Article

Elkalioubie¹,

Jude²,

Dupont³

2011

Diagnosis and Treatment of Abdominal and Thoracic Aortic Aneurysms Including the Ascending Aorta and the Aortic Arch

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“…These results can be explained by the severity of inflammation contributing to both disease states. For instance, a study by Simons and associates measured carotid intima media thickness (IMT), an indicator of atherosclerosis, between PVD and AAA patients and found that PVD patients had a greater carotid IMT thickening compared to AAA patients (18). These results, like our own, support the hypothesis that inflammation plays a more critical role in the pathogenesis of PVD, while only partially contributing to the development of AAA.…”

Section: Discussionmentioning

confidence: 99%

Monocytic adhesion molecule expression and monocyte–endothelial cell dysfunction are increased in patients with peripheral vascular disease versus patients with abdominal aortic aneurysms

Lee

Spyk

Chun

et al. 2012

Journal of Surgical Research

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Objective Statin therapy is utilized in the medical management of patients with peripheral vascular disease (PVD) and abdominal aortic aneurysm (AAA) for the pleiotropic and anti-inflammatory benefits. We hypothesize that the inflammatory mechanisms of monocyte-endothelial cell interactions in endothelial barrier dysfunction is more significant in patients with PVD compared to AAA. The purpose of this study is to assess patient peripheral blood monocyte adhesion molecules by flow cytometry and monocyte-induced endothelial barrier dysfunction by using an in vitro endothelial cell layer and electric cell-substrate impedance sensing system (ECIS). Methods Peripheral blood was collected from patients with either PVD (ABI<0.9, toe-arm index <0.8, or required lower extremity vascular intervention) or AAA (aortic diameter >3.0 cm). Monocytes were isolated from fresh whole blood using an accuspin-histopaque technique. The separated monocytes underwent flow cytometry analysis to evaluate expression levels of the cell membrane adhesion molecules: CD18, CD11a/b/c, and VLA-4. Endothelial cell function was assessed by adding monocytes to an endothelial monolayer on ECIS arrays and co-culturing overnight. Peak changes in trans-endothelial resistance were measured and compared between patient groups. Results Twenty-eight monocyte samples were analyzed for adhesion molecules (PVD: 19, AAA: 9) via flow cytometry and 11 patients were evaluated for endothelial dysfunction (PVD: 7, AAA: 4) via ECIS. There was no significant difference between risk factors among PVD and AAA patients except for age, where AAA patients were significantly older than PVD patients in both flow cytometry and ECIS groups (P=0.02, 0.01 respectively). There were significantly higher levels of adhesion molecules CD11a, CD18, and CD11c (averaged MFI P-values: 0.047, 0.038, 0.014, respectively) in PVD patients compared to AAA patients. No significant difference was found for CD11b and VLA-4 expression (P=0.21, 0.15 respectively). There was significantly more monocyte-endothelial cell dysfunction as a result of monocytes obtained from patients with PVD than from AAA, with a maximal effect seen at 15 hours after monocyte addition (P=0.032). Conclusions Patients with PVD have increased expression levels of certain monocyte adhesion molecules and greater monocyte-induced endothelial layer dysfunction when compared to patients with AAA. This may lead to other methods of targeted therapy to improve outcomes of these vascular patients.

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“…Higher values in PAD patients are associated with manifest atherosclerosis [9,13]. Within the PAD group, the mIMT in patients with isolated PAD at the stage of mild intermittent claudication (mean ABPI 0.67) is not different from the mIMT in PAD patients with systemic atherosclerosis at the stage of severe intermittent claudication or critical limb ischemia (mean ABPI 0.47).…”

Section: Discussionmentioning

confidence: 93%

“…IMT is regarded to be a surrogate marker of generalized atherosclerosis and therefore a reliable indicator of cardiovascular risk [8]. High IMT values have been reported in patients with PAD [9][10][11][12][13]. This patient group has a very high risk of experiencing a future coronary or cerebrovascular event (fatal or nonfatal) [14].…”

Section: Introductionmentioning

confidence: 99%

Common carotid intima-media thickness in peripheral arterial disease

et al. 2011

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The common carotid intima-media thickness (IMT) is regarded as a reliable predictor of cardiovascular morbidity. Patients with peripheral arterial disease (PAD) have an increased risk of cardiovascular morbidity and mortality, and PAD is associated with increases in IMT. The aim of this study was to establish whether IMT would be a suitable parameter for predicting cardiovascular risk in individual patients with PAD and the factors involved in determining IMT in these patients. This prospective study included 314 subjects: 112 patients with isolated PAD, 85 patients with PAD and additional coronary and/or cerebrovascular atherosclerosis, and 117 subjects without atherosclerotic disease. Maximum IMT (mIMT) was measured using high-resolution B-mode ultrasonography. Patients with isolated PAD were examined for influencing factors on mIMT. The mIMT in patients with isolated PAD (1.01 ± 0.2 mm) was not significantly different from that of patients with PAD and additional systemic atherosclerosis (1.01 ± 0.17 mm). Controls showed a significantly lower mIMT (0.71 ± 0.15 mm). In multivariate stepwise regression analysis, the chief influencing factors on mIMT in patients with isolated PAD included age as well as fasting insulin and plasminogen activator inhibitor-1 (PAI-1). We found significant correlations between mIMT and the presence of microalbuminuria in nondiabetics with PAD. The highly increased mIMT values of patients with isolated PAD reflect the elevated cardiovascular risk which is already present in the early clinical stages of PAD. The links between fasting insulin, PAI-1, microalbuminuria, and older age with mIMT in isolated PAD are at the same time important predictors of the development of systemic atherosclerosis in PAD.

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Common carotid intima-media thickness in patients with peripheral arterial disease or abdominal aortic aneurysm: the SMART study

Cited by 38 publications

References 40 publications

Abdominal Aortic Aneurysm in Patients with Coronary Artery Disease: A Review Article

Abdominal Aortic Aneurysm in Patients with Coronary Artery Disease: A Review Article

Monocytic adhesion molecule expression and monocyte–endothelial cell dysfunction are increased in patients with peripheral vascular disease versus patients with abdominal aortic aneurysms

Common carotid intima-media thickness in peripheral arterial disease

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