Common behavioral problems among children wıth asthma: Is there a role of asthma treatment?

Impact of asthma medication and familial factors on the association between childhood asthma and attention‐deficit/hyperactivity disorder: a combined twin‐ and register‐based study

“…Asthma severity and medication are however tightly linked, and it is possible that medication rather than asthma is the explanation for the association. Treatment with β 2 ‐agonists and inhaled corticosteroids (ICS) has been reported to cause behavioural side effects . However, we did not find any significant difference in hyperactivity–impulsivity between asthmatic children with or without asthma medication .…”

Preschool children with high adherence to inhaled corticosteroids for asthma do not show behavioural problems

“…This is illustrated by the recent finding that more than 20% of reported side effects of ICS in a national Dutch pharmacovigilance database concerned behavioural problems (5). Our study, together with two recently published case–control studies (8,9), however, did not find any association between ICS use and behavioural problems in children. Although this does not exclude behavioural side effect in isolated cases, these findings argue against behavioural problems as a relevant and common side effect of ICS therapy in young children.…”

“…In a case control study of teenagers, anxiety and depression were more common in asthmatics than in controls (7). In two case-control studies of school-aged children, there was no significant association between ICS use and behavioural abnormalities (8,9). In none of these studies, however, was adherence to ICS taken into account, so the dose of ICS that these children were exposed to was unknown.…”

Risk Factors for Attention and Behavioral Issues in Pediatric Sickle Cell Disease

“…15 Children with asthma are also thought to be at higher risk for ADHD in the general pediatric population, though the evidence is conflicting. 16-20 In addition, both disorders are quite common in this group; 30% to 70% of patients with SCD have asthma, while one study found that 51% of children with SCD had behavioral and emotional issues per parental and teacher report. 13,21 The relationship between asthma and behavioral issues in our study is also confounded by gender and SCD type, as it is no longer a significant association when these factors are not adjusted for in a model.…”