Common antigens between hydatid cyst and cancers

Daneshpour, Shima; Bahadoran, Mehran; Hejazi, Seyed Hossein; Eskandarian, Abas Ali; Mahmoudzadeh, Mehdi; Darani, Hossein Yousofi

doi:10.4103/2277-9175.175242

Cited by 18 publications

(2 citation statements)

References 34 publications

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“…Cancer cells can be induced to undergo apoptosis by AgB, the growth of tumors can be slowed down, and immune cells attack tumors more effectively by AgB (Noya et al, 2013;Zheng, 2013). Antigen 1 (Ag1) and Antigen 5 (Ag5) from E. granulosus have also been investigated concerning their anticancer capabilities (Daneshpour et al, 2016;Darani et al, 2016;Sharafi et al, 2018;Bo et al, 2020).…”

Section: Echinococcus Granulosusmentioning

confidence: 99%

“…DOI: https://dx.doi.org/10.54203/scil. 2023.wvj65 There is significant evidence that helminth infestation improves survival rates, inhibits tumor growth, and minimizes metastasis in animal infestation models (Daneshpour et al, 2016;Berriel et al, 2021). Some preliminary clinical trials conducted with helminths showed promising results, such as tumor regression, immune activation, and improved overall survival in patients treated with helminths (Aref et al, 2013;Daneshpour et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Using Helminths to Fight Cancer: An Innovative Approach

Ameli,

Masoumi,

Kerachi

et al. 2023

WVJ

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As an alternative treatment in cancer therapy, there has been a growing interest in using helminths, such as Trichinella spiralis (T. spiralis), Echinococcus granulosus (E. granulosus), Toxocara canis (T. canis), and Taenia solium (T. solium). This study aimed to investigate the antigens and mechanisms that contribute to the anticancer properties of helminths, providing insights into how helminths may be used as a new and innovative treatment modality for cancer. The current review analyzed preclinical and clinical studies published between 2000 and 2023. The present study sought to obtain information on helminths, such as E. granulosus, T. spiralis, T. canis, and T. solium, to treat cancers of the breast, pancreas, melanoma, and leukemia by exploring databases, such as PubMed, Google Scholar, and Scopus. Studies focusing on helminth therapy against particular cancer types for in vitro and animal models were included. Several studies have shown the possibility of inhibiting breast, colon, melanoma, and leukemia tumor growth, inducing apoptosis, and modulating the tumor microenvironment with E. granulosus, T. spiralis, T. canis, and T. solium based on in vitro and animal models studies. Some studies have indicated that helminth therapy can improve survival rates, reduce tumor growth, and stimulate the immune system in cancer patients. A potential improvement in treatment outcomes can be used for combination therapies, such as antigen selection, immune profiling, and individualized approaches based on helminth therapy. Helminth therapy is an additional option for cancer treatment, emphasizing T. spiralis, E. granulosus, T. canis, and T. solium. These helminth antigens could modulate immune responses and directly cause cytotoxicity in cancer cells.

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Section: Echinococcus Granulosusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Using Helminths to Fight Cancer: An Innovative Approach

Ameli,

Masoumi,

Kerachi

et al. 2023

WVJ

View full text Add to dashboard Cite

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Copper(I)‐Thiosemicarbazone Complexes with Dual Anticancer and Antiparasitic Activity

et al. 2023

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Four new Cu(I) complexes of the general formula [Cu-(PP)(LL)][BF 4 ], in which PP is a phosphane ligand (triphenylphosphane or 1,2-bis(diphenylphosphano)ethane (dppe)) and LL is a bioactive thiosemicarbazone ligand (4-(methyl)-1-(5nitrofurfurylidene)thiosemicarbazone) or 4-(ethyl)-1-(5nitrofurfurylidene)thiosemicarbazone) were synthesized and fully characterized by classical analytical and spectroscopic methods. The anti-trypanosome and anticancer activities were investigated in vitro on Trypanosoma cruzi and in two human cancer cell lines (ovarian OVCAR3 and prostate PC3). To test the selectivity toward parasites and cancer cells, the cytotoxicity on normal monkey kidney VERO and human dermal fibroblasts HDF cells was also evaluated. The new heteroleptic complexes were more cytotoxic on T. cruzi and chemoresistant prostate PC3 cells than the benchmark drugs nifurtimox and cisplatin. The compounds also showed a high level of cellular internalization by the OVCAR3 cells and, in particular, those containing the dppe phosphane showed activation of the cell death mechanism via apoptosis. On the other hand, the production of reactive oxygen species induced by these complexes was not evident.

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