Common and uncommon manifestations of wegener's granulomatosis

Travis, William D.

doi:10.1016/1054-8807(94)90032-9

Cited by 19 publications

(8 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was understandable, given the broad spectrum of "typical" and "atypical" histological lung injury patterns that may occur in WG or MPA (Table 2; [17][18][19][20][21][22][23][24][25][26][27][28][29][30]. Some of these "atypical" patterns (i.e., NSIP, BOOP, DAD, or pleuritis) overlapped with the findings that were seen in our patients, but no vasculitic changes were evident.…”

Section: Discussionmentioning

confidence: 99%

Antineutrophil Cytoplasmic Autoantibody in the Absence of Wegener's Granulomatosis or Microscopic Polyangiitis: Implications for the Surgical Pathologist

Gal

Velasquez

2002

Modern Pathology

View full text Add to dashboard Cite

Antineutrophil cytoplasmic antibodies (ANCA) are useful serologic markers for the diagnosis and management of patients with Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA). However, problems in diagnosis and classification may occur when patients with other disorders develop ANCA. A 7-year review (1993-1999) disclosed 247 patients whose sera tested positively for ANCA by an indirect immunofluorescence method: 166 patients for cytoplasmic-ANCA (C-ANCA) and 81 patients for perinuclear-ANCA (P-ANCA) Twenty-seven patients had active pulmonary disease and underwent openlung biopsy or transbronchial biopsy. Eight patients (30%) had a disease other than WG or MPA, and their clinical, pathological, and serological findings were reviewed. The patients, all women, ranged in age from 28 to 77 years (median, 37 y). Dyspnea (n ‫؍‬ 6), cough (n ‫؍‬ 6), chest pain (n ‫؍‬ 2), and/or hemoptysis (n ‫؍‬ 2) were present. The duration of symptoms lasted from 3 weeks to 6 years (median, 6 mo). ANCA titers were C-ANCA (n ‫؍‬ 4; range, 1:40 -1280) or P-ANCA (n ‫؍‬ 4; range, 1:40 -640). The lung biopsies disclosed nonspecific interstitial pneumonia (n ‫؍‬ 4), bronchiolitis obliterans organizing pneumonia (n ‫؍‬ 1), diffuse alveolar damage (n ‫؍‬ 1), organizing diffuse alveolar hemorrhage without capillaritis (n ‫؍‬ 1), and necrotic granuloma (n ‫؍‬ 1). No cases showed characteristic histology for WG or MPA. The final diagnoses were various connective tissue disorders (n ‫؍‬ 5), chronic hypersensitivity pneumonia (n ‫؍‬ 1), postinfectious bronchitis/bronchiectasis (n ‫؍‬ 1), and ulcerative colitis-related lung disease (n ‫؍‬ 1). Surgical pathologists should be aware that significantly elevated ANCA titers may be associated with diverse forms of pulmonary disease. ANCA positivity alone, in the absence of appropriate clinical or pathologic findings, should not be used to substantiate a diagnosis of WG or MPA.

show abstract

Section: Discussionmentioning

confidence: 99%

Antineutrophil Cytoplasmic Autoantibody in the Absence of Wegener's Granulomatosis or Microscopic Polyangiitis: Implications for the Surgical Pathologist

Gal

Velasquez

2002

Modern Pathology

View full text Add to dashboard Cite

show abstract

“…(7). Xanthogranulomatous lesions, which may be seen in lung biopsies diagnostic of WG (34), may also occur in salivary WG (18).…”

Section: Histopathological Findingsmentioning

confidence: 99%

Wegener’s granulomatosis of the major salivary glands

Barrett

2012

J Oral Pathology Medicine

View full text Add to dashboard Cite

Wegener's granulomatosis is one of the anti-cytoplasmic autoantibodies (ANCA)-associated vasculitides. Although it typically affects the lungs and kidneys, the head and neck are also involved in most cases but the site usually affected is the upper airway. However, there are 35 cases with well-documented clinicopathological data in which Wegener's granulomatosis manifested in the major salivary glands, most commonly the parotid. Twenty-four patients presented with salivary signs and symptoms, in eight of whom there was no other presenting manifestation. These signs and symptoms may mimic infection or neoplasia and laboratory investigations, including ANCA serology and histopathology, may be non-specific; thus, in 21 of the 35 patients (60%) there was a delay in diagnosis. Amongst the 21 were 11 of the 14 (78.6%) patients who presented with unilateral parotid disease and three of the five who died. Three other patients suffered permanent pulmonary, two renal and five facial nerve damage. This article reviews the literature on major salivary gland involvement in Wegener's granulomatosis, which should be considered in the differential diagnosis of major salivary gland disease particularly if commoner causes have been excluded. A detailed medical history, and persistently inconclusive laboratory tests, could provide the clues that enable prompt diagnosis.

show abstract

“…The disease primarily involves the lungs, upper respiratory tract and kidneys, although it can develop in practically any organ system [1][2][3][4]. In 1990, the American College of Rheumatology (ACR) defined four criteria for classification of WG to distinguish patients with WG from those with other forms of vasculitis [1]: abnormal urinary sediment, abnormal findings on chest radiograph, oral ulcers and nasal discharge, and granulomatous inflammation on biopsy.…”

Section: Introductionmentioning

confidence: 99%

Wegener's granulomatosis of the breast

Neralić-Meniga

Ivanovi-Herceg

Mažuranić

et al. 2006

Wien Klin Wochenschr

View full text Add to dashboard Cite

Wegener's granulomatosis is a multisystem disorder characterized by necrotizing granulomatous inflammation and vasculitis of small vessels and can affect any organ system. The most common sites of involvement are upper and lower respiratory tracts, and kidneys. Breast involvement is unusual and very rare. We report a case of breast Wegener's granulomatosis in a 32-year-old woman who presented with pulmonary lesions and palpable masses in the left breast. Mammography showed multiple, sharply delineated nodules without microcalcifications. Ultrasonography revealed multiple hypoechoic solid lesions, some of them with anechoic areas of necrosis. Computed tomography showed multiple nodules. Histopathology of excision biopsy specimens of breast lesions revealed necrotizing granulomatous material consistent with Wegener's granulomatosis. Twenty reports of breast involvement in this rare disease were found in the literature; however, the respective ultrasonographic and computed tomography findings have not hitherto been described.

show abstract

Common and uncommon manifestations of wegener's granulomatosis

Cited by 19 publications

References 87 publications

Antineutrophil Cytoplasmic Autoantibody in the Absence of Wegener's Granulomatosis or Microscopic Polyangiitis: Implications for the Surgical Pathologist

Antineutrophil Cytoplasmic Autoantibody in the Absence of Wegener's Granulomatosis or Microscopic Polyangiitis: Implications for the Surgical Pathologist

Wegener’s granulomatosis of the major salivary glands

Wegener's granulomatosis of the breast

Contact Info

Product

Resources

About