Common and divergent neural correlates of anomia in amnestic and logopenic presentations of Alzheimer's disease

Leyton, Cristian E.; Hodges, John R.; Piguet, Olivier; Ballard, Kirrie J.

doi:10.1016/j.cortex.2016.10.019

Cited by 39 publications

(22 citation statements)

References 52 publications

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“…While these patients have some difficulty with visual confrontation naming, a particularly marked deficit has been observed in lexical retrieval during the course of conversational speech (Leyton et al 2017). Indeed, deficits with lexical retrieval are fairly ubiquitous among all progressive aphasics; thus, criteria incorporating this impairment as a defining feature are less helpful.…”

Section: Logopenic Variant Primary Progressive Aphasiamentioning

confidence: 99%

Linguistic Aspects of Primary Progressive Aphasia

Grossman

2018

Annu. Rev. Linguist.

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Primary progressive aphasia (PPA) refers to a disorder of declining language associated with neurodegenerative diseases such as frontotemporal degeneration and Alzheimer disease. Variants of PPA are important to recognize from a medical perspective because these syndromes are clinical markers suggesting specific underlying pathology. In this review, I discuss linguistic aspects of PPA syndromes that may prove informative for parsing our language mechanism and identifying the neural representation of fundamental elements of language. I focus on the representation of word meaning in a discussion of semantic variant PPA, grammatical comprehension and expression in a discussion of nonfluent/agrammatic variant PPA, the supporting role of short-term memory in a discussion of logopenic variant PPA, and components of language associated with discourse in a discussion of behavioral variant frontotemporal dementia. PPA provides a novel perspective that uniquely addresses facets of language and its disorders while complementing traditional aphasia syndromes that follow stroke.

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Section: Logopenic Variant Primary Progressive Aphasiamentioning

confidence: 99%

Linguistic Aspects of Primary Progressive Aphasia

Grossman

2018

Annu. Rev. Linguist.

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“…For this study, we were interested in analysing the types of errors. Therefore, error production was classified as one of the following subtypes: pure semantic errors – ‘substituted nouns that related to the target either taxonomically or associatively, and that were not also phonologically related’; and omissions, including no response, unrelated responses (e.g., ‘I've seen it before’, ‘I know it’), or partial description without providing a name (Dell, Lawler, Harris, & Gordon, ; Kittredge, Dell, Verkuilen, & Schwartz, ; Lambon Ralph, Cipolotti, Manes, & Patterson, ; Leyton, Hodges, Piguet, & Ballard, ; Rohrer et al ., ).…”

Section: Methodsmentioning

confidence: 99%

Morphometric correlates of anomia in patients with small left temporopolar lesions

Alemán‐Gómez

Poch

Toledano

et al. 2019

Journal of Neuropsychology

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Visual object naming is a complex cognitive process that engages an interconnected network of cortical regions moving from occipitotemporal to anterior-inferior temporal cortices, and extending into the inferior frontal cortex. Naming can fail for diverse reasons, and different stages of the naming multi-step process appear to be reliant upon the integrity of different neuroanatomical locations. While the neural correlates of semantic errors have been extensively studied, the neural basis of omission errors remains relatively unspecified. Although a strong line of evidence supports an association between anterior temporal lobe damage and semantic errors, there are some studies suggesting that the anterior temporal lobe could be also associated with omissions. However, support for this hypothesis comes from studies with patients in whom damage affected extensive brain regions, sometimes bilaterally. Here, we availed of a group of 12 patients with epilepsy associated with a small lesion at the tip of the left temporal pole. Using an unbiased surface-based morphometry methodology, we correlated two morphological features with errors observed during visual naming. Analyses revealed a correlation between omission errors and reduced local gyrification index in three cortical clusters: one in the left anteromedial temporal lobe region (AMTL) and two in the left

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“…Frente a la anomia propia del envejecimiento no patológico, la anomia debida a la demencia tipo Alzheimer interfiere de forma dramática en la comunicación del hablante, dando lugar a una discapacidad comunicativa funcional (Kempler & Zalinski, 1994). En los casos de EA más castigados desde el punto de vista del lenguaje -aquellos que van acompañados por la variante logopénica de la afasia progresiva primaria-la anomia se presenta asociada a sustituciones fonológicas, parafasias semánticas, repetición anormal de palabras sueltas (Leyton, Hodges, Piguet & Ballard, 2017) y la aparición de circunloquios, o frases sustitutorias para expresar el significado de la palabra que no se consigue recuperar (Cuetos, 2012). Las personas con EA acceden ante todo a la forma fonológica de la palabra y, en consecuencia, producen numerosas respuestas falsas a estímulos conceptuales (Moayedfar, Purmohammad, Shafa, Shafa & Ghasisin, 2019).…”

Section: Marco Teóricounclassified

“…Estudios recientes (Leyton et al, 2017) han revelado que la anomia de EA correlaciona primariamente con la degeneración del giro temporal superior izquierdo, área cortical responsable de numerosos procesos lingüísticos (procesamiento fonológico, procesos gramaticales), entre los que destacan los procesos semánticos (Friederici, 2017). Una lesión o alteración en esta área cortical da lugar a la anomia pura, bajo cuyos efectos el hablante puede activar el significado que quiere transmitir, pero no puede acceder a las palabras para expresarlo (Cuetos, 2012).…”

Section: Marco Teóricounclassified

La habilidad léxico-semántica en la Enfermedad de Alzheimer: Un estudio de la fluidez verbal con categorías semánticas

Ivanova

Meilán²,

Martínez-Nicolás

et al. 2020

Rev. signos

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Language impairments in Alzheimer's disease (AD) primarily affect lexical and semantic levels, which significantly depend on the speaker's memory state. Qualitative shifts in semantic memory are due to neurodegenerative processes underlying dementia and give rise to anomia, or the speaker's inability to access and retrieve lexical units and their conceptual backgrounds. In this paper we aim at studying cognitive and semantic features of anomic deficit in AD and exploring the possibility to apply them in tests for early detection of dementia. For that purpose, we analyze the results from our experimental version of a classical test on semantic verbal fluency (SemVF) with nonpathological aged persons, persons with Mild Cognitive Impairment and persons with AD. The experimental version of the test introduces a division into four 15-minute intervals, in order to find out which processes of semantic access, either automatic or controlled, are impaired in different cognitive states of the elderly. Our results show a correlation between the cognitive state and the lexical-semantic ability of the speaker. Furthermore, they highlight, on the one hand, that the duration of the SemVF test should not be less than 60 seconds, with internal division into 4 15-second intervals, and, on the other hand, that some semantic categories-colours and fruit in particularare more prone to be affected by cognitive retrogenesis, which caracterizes AD dementia.

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Common and divergent neural correlates of anomia in amnestic and logopenic presentations of Alzheimer's disease

Cited by 39 publications

References 52 publications

Linguistic Aspects of Primary Progressive Aphasia

Linguistic Aspects of Primary Progressive Aphasia

Morphometric correlates of anomia in patients with small left temporopolar lesions

La habilidad léxico-semántica en la Enfermedad de Alzheimer: Un estudio de la fluidez verbal con categorías semánticas

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