Common and differential electrophysiological mechanisms underlying semantic object memory retrieval probed by features presented in different stimulus types

Chiang, Hsueh-Sheng; Eroh, Justin; Spence, Jeffrey S.; Motes, Michael A.; Maguire, Mandy J.; Krawczyk, Daniél C.; Brier, Matthew R.; Hart, John; Kraut, Michael A.

doi:10.1016/j.ijpsycho.2016.06.011

Cited by 9 publications

(15 citation statements)

References 66 publications

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“…In contrast to HA, the YA group showed differences across conditions after 500 ms post-stimulus onset in theta and alpha frequency power. In particular, consistent with our prior findings within similar time windows (Chiang et al, 2016;Ferree et al, 2009;Hart et al, 2013), YA demonstrated increased alpha ERD during retrieval compared to non-retrieval conditions, which might be linked to semantic integration of features which lead to object memory activation. In the subsequent time window (628 to 701 ms post-stimulus onset), YA had higher theta ERS during non-retrieval compared to retrieval conditions, which might be related to enhanced search for potential feature integration prior to making a final judgment (Yes/No response on button push).…”

Section: Discussionsupporting

confidence: 91%

“…These tests were performed to assess (1) normal aging effects by comparing YA to HA groups and (2) pathological aging effects by comparing HA to MCI groups, for all electrodes (N = 62) and all windows (N = 26) spanning from 188 to 1105 ms post stimulus onset. We chose this time window given that prior studies have shown effects within this time window on the SORT task (Chiang et al, 2014(Chiang et al, , 2015(Chiang et al, , 2016(Chiang et al, , 2020. A False Discovery Rate (FDR) < 0.05 from permutation tests was considered significant, which is a robust statistical approach commonly adopted in functional imaging studies to avoid excessive false negative results, so further corrections for multiple comparisons were not applied.…”

Section: Discussionmentioning

confidence: 99%

“…Electroencephalogram (EEG), with its millisecond temporal resolution and direct measure of post-synaptic neuronal activity, is a useful tool to study neural dynamics associated with semantic memory (Chiang et al, 2016(Chiang et al, , 2020. Previously, on EEG-based semantic object memory retrieval test (SORT), we observed differences in event-related potentials (ERPs) between (1) cognitively normal younger and older adults, and (2) individuals with MCI and cognitively normal older controls.…”

Section: Introductionmentioning

confidence: 99%

“…Prior EEG studies using time-frequency analysis have suggested functional roles of low and high beta (12-20 and 20-30 Hz, respectively) in lexical semantic retrieval (Bakker et al, 2015;Bastiaansen and Hagoort, 2006;Slotnick et al, 2002;Lewis & Bastiaansen, 2015;Weiss & Mueller, 2012). While theta (4-8 Hz) and alpha (8-12 Hz) oscillations have been linked to word or sentence processing (Bakker et al, 2015;Bastiaansen and Hagoort, 2006;Li & Yang, 2013;Shahin et al, 2009;Chiang et al, 2016). Also, the slower frequency bands (theta, alpha) are thought to be associated with domain-general processes such as cognitive control and attentional demands during semantic processing (Cavanagh & Frank, 2014;Klimesch, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Differences in EEG oscillations between normal aging and mild cognitive impairment during semantic memory retrieval

Chiang

Lydon

Kraut

et al. 2022

Preprint

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Semantic memory remains relatively stable with normal cognitive aging and declines in early stages of neurodegenerative disease. We measured electroencephalography (EEG) oscillatory correlates of semantic memory retrieval to examine the effects of normal and pathological aging. Twenty-nine cognitively healthy young adults (YA), 22 cognitively healthy aging adults (HA), and 20 patients with mild cognitive impairment (MCI) completed a semantic memory retrieval task with concurrent EEG recording in which they judged whether two words (features of objects) led to retrieval of an object (retrieval) or not (non-retrieval). Event-related power changes contrasting the two conditions (retrieval vs. non-retrieval) within theta, alpha, low-beta, and high-beta EEG frequency bands were analyzed across time to examine normal aging (YA versus HA) and pathological aging effects (HA versus MCI). Though no behavioral differences between the cognitively healthy groups were observed, we found later theta and alpha power differences between conditions only in YA, and a high-beta power difference between conditions only in HA. For pathological aging effects, we found reduced accuracy in MCI. While we found different EEG patterns of early beta power differences between conditions in MCI compared to HA, a low-beta power difference between conditions was found only in HA. We conclude that the aging brain relies on faster (beta) oscillations during the semantic memory task. With pathological aging, retrieval accuracy declines and patterns of beta oscillation changes. The findings improve understanding on age-related neural mechanisms underlying semantic memory and have implications for early detection of pathological aging.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Differences in EEG oscillations between normal aging and mild cognitive impairment during semantic memory retrieval

Chiang

Lydon

Kraut

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Electroencephalogram (EEG), with its millisecond temporal resolution and direct measure of post-synaptic neuronal activity, is a useful tool to study neural dynamics associated with semantic memory (Chiang et al, 2016(Chiang et al, , 2020. Previously, on the EEG-based SORT, we observed differences in event-related potentials (ERPs) between (1) cognitively normal younger and older adults and (2) individuals with MCI and cognitively normal older controls.…”

Section: Introductionmentioning

confidence: 99%

Differences in electroencephalography oscillations between normal aging and mild cognitive impairment during semantic memory retrieval

Chiang

Lydon

Kraut

et al. 2023

Eur J of Neuroscience

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Semantic memory remains relatively stable with normal cognitive aging and declines in early stages of neurodegenerative disease. We measured electroencephalography (EEG) oscillatory correlates of semantic memory retrieval to examine the effects of normal and pathological aging. Twenty‐nine cognitively healthy young adults (YA), 22 cognitively healthy aging adults (HA) and 20 patients with mild cognitive impairment (MCI) completed a semantic memory retrieval task with concurrent EEG recording in which they judged whether two words (features of objects) led to retrieval of an object (retrieval) or not (non‐retrieval). Event‐related power changes contrasting the two conditions (retrieval vs. non‐retrieval) within theta, alpha, low‐beta and high‐beta EEG frequency bands were examined for normal aging (YA vs. HA) and pathological aging effects (HA vs. MCI). With no behavioural differences between the two normal age groups, we found later theta and alpha event‐related power differences between conditions only in YA and a high‐beta event‐related power difference only in HA. For pathological aging effects, with reduced accuracy in MCI, we found different EEG patterns of early event‐related beta power differences between conditions in MCI compared with HA and an event‐related low‐beta power difference only in HA. Beta oscillations were correlated with behavioural performance only in HA. We conclude that the aging brain relies on faster (beta) oscillations during the semantic memory task. With pathological aging, retrieval accuracy declines and pattern of beta oscillation changes. The findings provide insights about age‐related neural mechanisms underlying semantic memory and have implications for early detection of pathological aging.

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A modified neural circuit framework for semantic memory retrieval with implications for circuit modulation to treat verbal retrieval deficits

Chiang,

Mudar,

Dugas

et al. 2024

Brain and Behavior

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Word finding difficulty is a frequent complaint in older age and disease states, but treatment options are lacking for such verbal retrieval deficits. Better understanding of the neurophysiological and neuroanatomical basis of verbal retrieval function may inform effective interventions. In this article, we review the current evidence of a neural retrieval circuit central to verbal production, including words and semantic memory, that involves the pre‐supplementary motor area (pre‐SMA), striatum (particularly caudate nucleus), and thalamus. We aim to offer a modified neural circuit framework expanded upon a memory retrieval model proposed in 2013 by Hart et al., as evidence from electrophysiological, functional brain imaging, and noninvasive electrical brain stimulation studies have provided additional pieces of information that converge on a shared neural circuit for retrieval of memory and words. We propose that both the left inferior frontal gyrus and fronto‐polar regions should be included in the expanded circuit. All these regions have their respective functional roles during verbal retrieval, such as selection and inhibition during search, initiation and termination of search, maintenance of co‐activation across cortical regions, as well as final activation of the retrieved information. We will also highlight the structural connectivity from and to the pre‐SMA (e.g., frontal aslant tract and fronto‐striatal tract) that facilitates communication between the regions within this circuit. Finally, we will discuss how this circuit and its correlated activity may be affected by disease states and how this circuit may serve as a novel target engagement for neuromodulatory treatment of verbal retrieval deficits.

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Common and differential electrophysiological mechanisms underlying semantic object memory retrieval probed by features presented in different stimulus types

Cited by 9 publications

References 66 publications

Differences in EEG oscillations between normal aging and mild cognitive impairment during semantic memory retrieval

Differences in EEG oscillations between normal aging and mild cognitive impairment during semantic memory retrieval

Differences in electroencephalography oscillations between normal aging and mild cognitive impairment during semantic memory retrieval

A modified neural circuit framework for semantic memory retrieval with implications for circuit modulation to treat verbal retrieval deficits

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