Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells

Shin, Jae Young; Nchang, Denis; Cho, Byoung Ok; Kang, Hyun Ju; Kim, Jisu; Jang, Seon Il

doi:10.3892/etm.2019.7721

Cited by 7 publications

(3 citation statements)

References 41 publications

(39 reference statements)

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“…ex Colebr., antibacterial, antifungal, anti-inflammatory, antioxidant, antimicrobial, asthma, skin wounds, sedative [114][115][116]; Bryonia spp., anti-inflammatory [117]; Carum carvi L., diuretic, dyspepsia, emmenagogue, gastrointestinal disorders [118,119]; Capparis spinosa L., antimicrobial, anti-inflammatory, hepatoprotector (aerial parts), hypocholesterolemic (fruit), hypoglycaemic (fruit), hypolipidemic (fruit) [120][121][122]; Centaurium erythraea Rafn., antipyretic, hepatoprotector [123,124]; Centaurea benedicta (L.) L., antischistosomiasis, wounds, antiulcer [125,126]; Ceterach officinarum Willd., antioxidant [127,128]; Cichorium endivia L., antioxidant (hypogeal parts), hepatoprotector [129,130]; Citrus medica L., antibacterial [131]; Cinnamomum camphora (L.) J. Presl, antifungal, anti-inflammatory, antiparasitic [132][133][134]; Cinnamomum verum J. Presl, airways, gastrointestinal disorders, strengthens the nervous system [135][136][137]; Citrullus colocynthis (L.) Schrad., anti-inflammatory [138]; Commiphora gileadensis (L.) C. Chr., antibacterial [139]; Commiphora myrrha (Nees) Engl., antibacterial, antifungal, anti-inflammatory, antioxidant, antiseptic, antihistamine, di-gestive, emmenagogue, stimulates the urinary tract, gingivitis, airways [140][141][142]; Crocus spp., gastrointestinal disorders, airways, sedative [143][144][145][146]; Cucumis melo L., antiinflammatory [147]; Cuminum cynumum L., emmenagogue, gastrointestinal disorders [118]; Curcuma longa L., gastrointest...…”

Section: Category Of Pathologymentioning

confidence: 99%

Ca’ Granda, Hortus simplicium: Restoring an Ancient Medicinal Garden of XV–XIX Century in Milan (Italy)

et al. 2021

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This work is based on the study of 150 majolica vases dated back to the mid XVII century that once preserved medicinal remedies prepared in the ancient Pharmacy annexed to the Ospedale Maggiore Ca’ Granda in Milan (Lombardy, Italy). The Hortus simplicium was created in 1641 as a source of plant-based ingredients for those remedies. The main objective of the present work is to lay the knowledge base for the restoration of the ancient Garden for educational and informative purposes. Therefore, the following complementary phases were carried out: (i) the analysis of the inscriptions on the jars, along with the survey on historical medical texts, allowing for the positive identification of the plant ingredients of the remedies and their ancient use as medicines; (ii) the bibliographic research in modern pharmacological literature in order to validate or refute the historical uses; (iii) the realization of the checklist of plants potentially present in cultivation at the ancient Garden, concurrently with the comparison with the results of a previous in situ archaeobotanical study concerning pollen grains. For the species selection, considerations were made also regarding drug amounts in the remedies and pedoclimatic conditions of the study area. Out of the 150 vases, 108 contained plant-based remedies, corresponding to 148 taxa. The remedies mainly treated gastrointestinal and respiratory disorders. At least one of the medicinal uses was validated in scientific literature for 112 out of the 148 examined species. Finally, a checklist of 40 taxa, presumably hosted in the Hortus simplicium, was assembled.

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Section: Category Of Pathologymentioning

confidence: 99%

Ca’ Granda, Hortus simplicium: Restoring an Ancient Medicinal Garden of XV–XIX Century in Milan (Italy)

et al. 2021

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“…In addition, the antimicrobial activity of the formulation M9 was higher than those of two commercial mouthwashes and one oral antifungal suspension [14]. Myrrh has also an antimicrobial activity; It is used for treatment of oral ulcers, gingivitis, sinusitis, glomerulonephritis, brucellosis and a variety of skin disorders [15]. Myrrh has a known anti-inflammatory effect proved by it is ability to supress interleukin 31 (IL-31) mRNA and IL-31 protein expressions, production of IL-31cytokine and inhibits histamine production.…”

Section: Introductionmentioning

confidence: 99%

In vitro Antibacterial effect ofCommiphora myrrhaOil against Dental Pathogens

Izzeldien

Abdulaziz

Ahmed

et al. 2020

Preprint

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Dental caries is a chronic contagious disease caused by the interaction of oral microorganisms, diet and host factors over time. Streptococcus mutans is considered as the main bacteria involvs in dental decay, while the level of Lactobacillus spp. is directly related to the presence or onset of caries. Commiphora myrrh is an ancient plant which extracts are used as antiseptic and anti-inflammatory for mouth and throat due to it is antimicrobial activity. This study assessed the impact of Commiphora myrrha on two bacteria Streptococcus mutans and Lactobacillus spp. involved in dental caries. Three samples of Streptococcus mutans bacteria were collected randomly from patients with dental caries in Khartoum dental teaching hospital, while Lactobacillus spp. were obtained from fermented milk. Disk and well diffusion methods were used to test the effect of four concentration (100,50,25 and 12.5 mg/ml) of Myrrh volatile oil, extracted by hydro-distillation technique. The biochemical analysis of Commiphora myrrha oil was carried out using Gas Chromatography/Mass Spectrophotometric technique. The finding revealed that the four concentrations of oil were effective on Streptococcus mutans with the largest inhibition zone (18.7± 0.6 mm) through the well diffusion method and inhibition zone of(14.00 mm) with disc diffusion method regardless the two methods this inhibition zones were recorded at 100 mg/ml, with Minimum Bactericidal Concentration (MBC) at 3.125 mg/ml. While Lactobacillus spp. bacteria sensitive to three concentrations (100,50 and 25 mg/ml) and resistance to concentration 12.5 mg/ml, it is MBC found to be 25 mg/ml. In conclusion, this research revealed that Myrrh oil is effective on both S.mutans and Lactobacillus spp. Hence, Myrryh oil is a potential antibacterial product of interest in dental caries.

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“…Myrrh is a yellow fragrant oleo-gum resin exuded from the bark of trees belonging to the Commiphora species. Commiphora resin has long been used as a traditional medicine in various societies to treat different diseases such as tumors, fever, and stomach complaints [2][3][4]. It contains many active ingredients, which have the potential for the treatment of various diseases.…”

Section: Introductionmentioning

confidence: 99%

Potential Anti-Inflammatory Properties Effect of Myrrh

2020

Lett Appl NanoBioSci

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The natural gum Myrrh, a resinous extrude of genus Commiphora species, has found several applications, especially in traditional medicine. Myrrh has been used for treating different diseases, including inflammatory diseases, in diverse communities across the world. Allopathic usage of Myrrh, however, is limited by knowledge deficits regarding pharmacological mechanisms underlying these clinical effects, in particular, its anti-inflammatory role. This review aims to provide up-to-date information on the effect of myrrh extracts as well as its bioactive compounds on the functions of white blood cells and inflammatory mediators. Relevant information about the impact of Myrrh on the functions of white blood cells and inflammatory mediators was collected from established scientific databases such as NCBI, Web of Science, and Google Scholar. A few books were also referred to as obtaining important information. Myrrh and its bioactive molecules have been shown to have potential effects on the functions of white blood cells and immunomodulatory activities. However, few studies have reported these effects. In-depth studies are necessary to determine the effect of Myrrh and its bioactive molecules on immune cells and inflammatory mediators.

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Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells

Cited by 7 publications

References 41 publications

Ca’ Granda, Hortus simplicium: Restoring an Ancient Medicinal Garden of XV–XIX Century in Milan (Italy)

Ca’ Granda, Hortus simplicium: Restoring an Ancient Medicinal Garden of XV–XIX Century in Milan (Italy)

In vitro Antibacterial effect ofCommiphora myrrhaOil against Dental Pathogens

Potential Anti-Inflammatory Properties Effect of Myrrh

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