Commercially Available Probiotics and Prebiotics Used in Human and Animal Nutrition

Muzaffar, Khalid; Jan, Romee; Bhat, Naseer Ahmad; Gani, Adil; Shagoo, Mudasir Ahmed

doi:10.1016/b978-0-12-822909-5.00025-3

Cited by 5 publications

(6 citation statements)

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“…Probiotics are becoming increasingly popular and recognized as generally recognized as safe (GRAS) strains for humans and animals, mostly including species of Bacillus, Bifidobacterium, Lactobacillus, Streptococcus, and the yeast Saccharomyces boulardii 46,47 . Even though it is classified as a GRAS strain, it is not exempt from acquiring antimicrobial resistance (AMR) genes following the FDA regulation 48 .…”

Section: Discussionmentioning

confidence: 99%

Nanopore Sequencing Discloses Compositional Quality of Commercial Probiotic Feed Supplements

Kruasuwan

Jenjaroenpun

Arigul

et al. 2023

Sci Rep

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The market for the application of probiotics as a livestock health improvement supplement has increased in recent years. However, most of the available products are quality-controlled using low-resolution techniques and un-curated databases, resulting in misidentification and incorrect product labels. In this work, we deployed two workflows and compared results obtained by full-length 16S rRNA genes (16S) and metagenomic (Meta) data to investigate their reliability for the microbial composition of both liquid and solid forms of animal probiotic products using Oxford Nanopore long-read-only (without short-read). Our result revealed that 16S amplicon data permits to detect the bacterial microbiota even with the low abundance in the samples. Moreover, the 16S approach has the potential to provide species-level resolution for prokaryotes but not for assessing yeast communities. Whereas, Meta data has more power to recover of high-quality metagenome-assembled genomes that enables detailed exploration of both bacterial and yeast populations, as well as antimicrobial resistance genes, and functional genes in the population. Our findings clearly demonstrate that implementing these workflows with long-read-only monitoring could be applied to assessing the quality and safety of probiotic products for animals and evaluating the quality of probiotic products on the market. This would benefit the sustained growth of the livestock probiotic industry.

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Section: Discussionmentioning

confidence: 99%

Nanopore Sequencing Discloses Compositional Quality of Commercial Probiotic Feed Supplements

Kruasuwan

Jenjaroenpun

Arigul

et al. 2023

Sci Rep

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“…Such mixtures consist of "good" bacteria (probiotics) and a nondigestible carbohydrate source (prebiotics) that encourage the growth of beneficial bacteria by favorably modifying the intestinal microflora and metabolism (Awad et al, 2009;El-Banna et al, 2010;Koyun et al, 2022;Melara et al, 2022). Benefits of regular consumption of probiotics and prebiotics include enhanced immune function, improved colonic integrity, decreased incidence and duration of intestinal infections, downregulated allergic responses, and improved digestion (Muzaffar et al, 2021). It is assumed that the individual properties of pre-and probiotics may complement each other or act synergistically (Markowiak and Śliżewska, 2018;Muzaffar et al, 2021;Reehana et al, 2021).Studies have suggested that prebiotics may increase the survival of probiotic bacteria that pass through the upper GI tract and thus enhance their activity in the large intestine (Fooks et al, 1999;Roberfroid, 2000;Yan and Polk, 2020;Da Silva et al, 2021).…”

Section: Synbioticsmentioning

confidence: 99%

“…Benefits of regular consumption of probiotics and prebiotics include enhanced immune function, improved colonic integrity, decreased incidence and duration of intestinal infections, downregulated allergic responses, and improved digestion (Muzaffar et al, 2021). It is assumed that the individual properties of pre-and probiotics may complement each other or act synergistically (Markowiak and Śliżewska, 2018;Muzaffar et al, 2021;Reehana et al, 2021).Studies have suggested that prebiotics may increase the survival of probiotic bacteria that pass through the upper GI tract and thus enhance their activity in the large intestine (Fooks et al, 1999;Roberfroid, 2000;Yan and Polk, 2020;Da Silva et al, 2021). It is also understood that the individual properties of pre-and probiotics may be complementary or they may act synergistically (Bielecka et al, 2002;Muzaffar et al, 2021;Reehana et al, 2021).…”

Section: Synbioticsmentioning

confidence: 99%

“…It is assumed that the individual properties of pre-and probiotics may complement each other or act synergistically (Markowiak and Śliżewska, 2018;Muzaffar et al, 2021;Reehana et al, 2021).Studies have suggested that prebiotics may increase the survival of probiotic bacteria that pass through the upper GI tract and thus enhance their activity in the large intestine (Fooks et al, 1999;Roberfroid, 2000;Yan and Polk, 2020;Da Silva et al, 2021). It is also understood that the individual properties of pre-and probiotics may be complementary or they may act synergistically (Bielecka et al, 2002;Muzaffar et al, 2021;Reehana et al, 2021). Complementary synbiotics are comprised of a probiotic and a prebiotic that work independently to achieve one or more health benefits.…”

Section: Synbioticsmentioning

confidence: 99%

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Feed Additives of Bacterial Origin as an Immunoprotective or Immunostimulating Factor – A Review

Szuba-Trznadel

Rząsa

2023

Annals of Animal Science

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Since January 2006 when using antibiotics as growth promoters in animal feed have been banned scientists are looking for the best resolution to apply alternative substances. Extensive research into the health-promoting properties of probiotics and prebiotics has led to significant interest in the mechanisms of action of the combined administration of these feed additives as a synbiotic. Subsequent research has led to the development of new products. Among the most important health benefits of additives are, inhibiting the growth of pathogenic bacteria in the GI tract, maintenance of homeostasis, treatment of inflammatory bowel diseases, and increase in immunity. Specific immunomodulatory mechanisms of action are not well understood and the effect is not always positive, though there are no reports of adverse effects of these substances found in the literature. For this reason, research is still being conducted on their proper application. However, due to the difficulties of carrying out research on humans, evidence of the beneficial effect of these additives comes mainly from experiments on animals. The objective of the present work was to assess the effect of probiotics, prebiotics, and synbiotics, as well as new additives including postbiotics, proteobiotics, nutribiotics, and pharmabiotics, on specific immunomodulatory mechanisms of action, increase in immunity, the reduction of a broad spectrum of diseases.

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“…The second kind of lactase deficit is a birth defect in lactase production, which is brought on by a genetic defect and is defined by patients having either little or nonexistent lactase enzyme at all. The third kind, sometimes referred to as secondary lactase deficit, is when there are inadequate levels of this enzyme as a result of a GI tract issue ( Paulo, 2018 ; Szilagyi et al, 2019 ; Muzaffar et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Characterization of an isolated lactase enzyme produced by Bacillus licheniformis ALSZ2 as a potential pharmaceutical supplement for lactose intolerance

Amin,

Olama,

Ali

2023

Front. Microbiol.

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IntroductionLactose intolerance is a widespread problem that affects people of many different races all over the world. The following pharmacological supplements can improve the lives of those who suffer from this issue.MethodsThis work focused on lactase producer isolation and statistical design (Plackett–Burman, and BOX–Behnken) to maximize the effectiveness of environmental factors. A lactase-producing bacterium was chosen from a discovery of 100 strains in soil that had previously been polluted with dairy products. Plackett-Burman investigated fifteen variables.ResultsThe most critical variables that lead to increased lactase synthesis are glucose, peptone, and magnesium sulfate (MgSO4). The ideal process conditions for the creation of lactase yield among the stated variables were then determined using a BOX-Benken design. To establish a polynomial quadratic relationship between the three variables and lactase activity, the Box–Behnken design level was used. The EXCEL-solver nonlinear optimization technique was used to predict the best form for lactase production. The ideal temperature and pH levels have been determined, both before and after the lactase purification process, to achieve the highest performance of isolated lactase.ConclusionAccording to this study, Bacillus licheniformis is a perfect supply of the lactase enzyme (β -Galactosidase), It can be used as a product to assist people who have health issues due to lactose intolerance.

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Commercially Available Probiotics and Prebiotics Used in Human and Animal Nutrition

Cited by 5 publications

References 125 publications

Nanopore Sequencing Discloses Compositional Quality of Commercial Probiotic Feed Supplements

Nanopore Sequencing Discloses Compositional Quality of Commercial Probiotic Feed Supplements

Feed Additives of Bacterial Origin as an Immunoprotective or Immunostimulating Factor – A Review

Characterization of an isolated lactase enzyme produced by Bacillus licheniformis ALSZ2 as a potential pharmaceutical supplement for lactose intolerance

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