Commercializing nanotechnology

Mazzola, Laura T

doi:10.1038/nbt1003-1137

Cited by 273 publications

(163 citation statements)

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“…In the past decade, there has been a drastic increase in the use of nanoparticles (NPs) in a diverse array of industrial and medical applications, ranging from biomedicine, nano-electronics to mechanical engineering (Mazzola, 2003;Paull et al, 2003). However, with the increase in large scale production of manufactured nanoparticles, and intentional (McCarthy and Weissleder, 2008;Pons et al, 2010) or unintentional (Lee et al, 2010) exposure to NPs, the potential toxicity of such materials due to their large surface area and the potential to accumulate in the body has raised concern (Lewinski et al, 2008;Meng et al, 2009;Oberdörster et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

In vitro cytotoxicity and genotoxicity studies of titanium dioxide (TiO2) nanoparticles in Chinese hamster lung fibroblast cells

Hamzeh

Sunahara

2013

Toxicology in Vitro

119

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/npsi/ctrl?lang=en http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/ctrl?lang=fr Access and use of this website and the material on it are subject to the Terms and Conditions set forth at http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/jsp/nparc_cp.jsp?lang=en NRC Publications Archive Archives des publications du CNRCThis publication could be one of several versions: author's original, accepted manuscript or the publisher's version. / La version de cette publication peut être l'une des suivantes : la version prépublication de l'auteur, la version acceptée du manuscrit ou la version de l'éditeur. For the publisher's version, please access the DOI link below./ Pour consulter la version de l'éditeur, utilisez le lien DOI ci-dessous.http://dx.doi.org/10. 1016/j.tiv.2012.12.018 Toxicology in Vitro, 27, 2, pp. 864-873, 2012-12-28 In vitro cytotoxicity and genotoxicity studies of titanium dioxide (TiO2) nanoparticles in Chinese hamster lung fibroblast cells Hamzeh, Mahsa; Sunahara, Geoffrey I. Therefore, our objective was to investigate the cytotoxicity and genotoxicity of commercially available TiO 2 nanoparticles with respect to their selected physicochemical properties, as well as the role of surface coating of these nanoparticles. While all types of tested TiO 2 samples decrease cell viability in a mass-based concentration-and size-dependent manner, the polyacrylate-coated nano-TiO 2 product was only cytotoxic at higher concentrations. A similar pattern of response was observed for induction of apoptosis/necrosis, and no DNA damage was detected in the polyacrylate-coated nano-TiO 2 model. Given the increasing production of TiO 2 nanoparticles, toxicological studies should take into account the physiochemical properties of these nanoparticles that may help researchers to develop new nanoparticles with minimum toxicity.

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Section: Introductionmentioning

confidence: 99%

In vitro cytotoxicity and genotoxicity studies of titanium dioxide (TiO2) nanoparticles in Chinese hamster lung fibroblast cells

Hamzeh

Sunahara

2013

Toxicology in Vitro

119

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“…Based on the unique properties of nanoparticles different from bulk material, 1,2 nanometer-sized structures have shown potential applications in microfabrication, 3 information technology, 4 and new laser technology. 5 Letokhov predicted that the combination of multiple scattering and light amplification would lead to a form of laser action called random lasing.…”

Section: Two-photon Pumped Random Laser In Nanocrystalline Znomentioning

confidence: 99%

Two-photon pumped random laser in nanocrystalline ZnO

Chelnokov

Bityurin

Ozerov

et al. 2006

Applied Physics Letters

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International audienceThin film of ZnO nanoparticles with dimension of about 5–10 nm were fabricated by the pulsed laser ablation method. By using a femtosecond laser beam at 700 nm to pump micrometer-thick films the authors observed two-photon-induced lasing at 385 nm. Experimentally obtained dependence of the threshold on the excitation spot radius r0 is closer to (1/r_0^2) than to (1/r_0), thus suggesting efficiency of the feedback by scattering-random lasing. The experimental data on nonlinear transmission of the film at the wavelength of pumping are presented

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“…(v) Bureaucratic delays: Patent policies take up to thirty-six months to respond to a single application, a serious problem when even a slight delay can be detrimental. Due to lack of a coherent policy on technology transfer from universities to start-up businesses and a considerable red tape must be dealt with for any such transfer using black ocean strategy [6]. (vi) Dearth of funding: Since the research in nanotechnology is capital intensive due to the state-of-the-art instruments requirement, firms faces challenges in obtaining funding.…”

Section: Challenges For Nanotechnology Commercializationmentioning

confidence: 99%

“…The objective of the firm is to identify a market for its new products [6]. From a business perspective, the steps to be followed for the successful commercialization of a nanotechnology based product include market size, market potential, and the economic scenario of the countries and the people who use such products [7].…”

Section: Challenges For Nanotechnology Commercializationmentioning

confidence: 99%

Nanotechnology Innovations and Commercialization-Opportunities, Challenges & Reasons for Delay

Aithal¹,

Aithal²

2016

IJEM

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Innovations in nanotechnology are making a revolution in manufacturing and production, creating new materials and products through novel processes for commercial applications. New products based on nanotechnology with novel characteristics are continued to grow and benefit the society. Being general purpose technology, nanotechnology is expected to support all fields of the society, but some fields like medicine, energy, environmental remediation, robotics, manufacturing, commerce, and space exploration are expected to undergo explosive developments. In this paper, we made a detailed analysis of advantages, benefits, constraints, and disadvantages of progress in nanotechnology for the society and discussed the reason for the failure of estimated timeline for realizing various generations of progress and proposed a modified timeframe for anticipated nanotechnology innovations. Based on the business perspective, we have developed a nanotechnology products/services commercialization model and discussed the opportunities for nanotechnology commercialization. The paper also contains a detailed analysis of common commercialization challenges faced by nanotechnology firms including time lag, valley of death, lack of infrastructure, lack of standard for evaluation, bureaucratic delays, dearth of funding, and lack of trained professionals, brand image, and public support. Finally, we have mentioned how the various corporate business strategies can be used in the successful business of nanotechnology products and services.Index Terms: Commercialisations of nanotech products, Challenges in commercialization of new products, Nanotechnology commercialization model.

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Commercializing nanotechnology

Cited by 273 publications

References 5 publications

In vitro cytotoxicity and genotoxicity studies of titanium dioxide (TiO2) nanoparticles in Chinese hamster lung fibroblast cells

In vitro cytotoxicity and genotoxicity studies of titanium dioxide (TiO2) nanoparticles in Chinese hamster lung fibroblast cells

Two-photon pumped random laser in nanocrystalline ZnO

Nanotechnology Innovations and Commercialization-Opportunities, Challenges & Reasons for Delay

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