Commercial sunscreen formulations: UVB irradiation stability and effect on UVB irradiation-induced skin oxidative stress and inflammation

Vilela, Fernanda Maria Pinto; Oliveira, Franciane Mendes de; Vicentini, Fabiana T. M. C.; Casagrande, Rúbia; Verri, Waldiceu A.; Cunha, Thiago Mattar; Fonseca, Maria José Vieira

doi:10.1016/j.jphotobiol.2016.09.007

Cited by 20 publications

(8 citation statements)

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“…In addition, the phytochemicals present in C. verbenacea have demonstrated anti-inflammatory and antioxidant activities in various evaluation models and different types of treatments, as priorly exposed in this text [4,46,47,73,121,122]. In addition, finally, commercial sunscreens without antioxidants do not fully mimic the antioxidant activity observed with the current topical formulation [123] thus, suggesting that C. verbenacea photochemoprotective activity is tightly related to its biological antioxidant properties.…”

Section: Discussionmentioning

confidence: 85%

Protection against UVB deleterious skin effects in a mouse model: effect of a topical emulsion containing Cordia verbenacea extract

Melo

Saito

Vale

et al. 2021

Photochem Photobiol Sci

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Cordia verbenacea DC (Boraginaceae) is a flowering shrub found along the Brazilian Atlantic Forest, Brazilian coast, and low areas of the Amazon. The crude extract of its leaves is widely used in Brazilian folk medicine as an anti-inflammatory, both topically and orally. The aim of this study is to evaluate the activity of C. verbenacea ethanolic leaves extract (CVE) against UVB-triggered cutaneous inflammation and oxidative damage in hairless mice. CVE treatment recovered cutaneous antioxidant capacity demonstrated by scavenging ABTS + free radical and iron-reducing antioxidant potential evaluated by FRAP. CVE also controlled the following UV-triggered events in the skin: reduced glutathione (GSH) depletion, catalase activity decrease, and superoxide anion (O ⋅-) build-up. Furthermore, mice treated with CVE exhibited less inflammation, shown by the reduction in COX-2 expression, TNF-α, IL-1β, IL-6, edema, and neutrophil infiltration. CVE also regulated epidermal thickening and sunburn cells, reduced dermal mast cells, and preserved collagen integrity. The best results were obtained using 5% CVE-added emulsion. The present data demonstrate that topical administration of CVE presents photochemoprotective activity in a mouse model of UVB inflammation and oxidative stress. Because of the intricate network linking inflammation, oxidative stress, and skin cancer, these results also indicate the importance of further studies elucidating a possible role of C. verbenacea in the prevention of UVB-induced skin cancer and evaluating a potential synergy between CVE and sunscreens in topical products against UVB damaging effects to the skin.

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Section: Discussionmentioning

confidence: 85%

Protection against UVB deleterious skin effects in a mouse model: effect of a topical emulsion containing Cordia verbenacea extract

Melo

Saito

Vale

et al. 2021

Photochem Photobiol Sci

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“…The cis isomer has a lower capacity to absorb UV irradiation and a consequent reduction in its photo-protective activity. 39,[48][49][50] The reduction of the photoprotection presented by the photounstable formulations, in addition to compromising the effectiveness of the protectors, not conferring adequate protection to the skin can also trigger the formation of degradation products potentially harmful to the skin, which can interact with skin components, mediating phototoxic and/or photoallergic processes. 28, 51,52 It is worth considering that even if the product were reapplied to the skin at time intervals to ensure photoprotection, the problem of skin contact with the toxic degradation products would not be eliminated, since the sunscreen would be applied on the skin layer already containing the filters products of degradation.…”

Section: Area Under De Curve Index (Auci)mentioning

confidence: 99%

Photostability of commercial sunscreens upon sunlight exposure

Prado

Bertges

Figueiredo³

et al. 2020

hu rev

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Introduction: The use of sunscreens is recommended to reduce skin damage and prevent skin cancer. However, evidence has shown that sunscreen can undergo degradation processes induced by ultraviolet (UV) radiation which can lead to reduction or loss of photoprotective capacity, generation of free radicals and toxic intermediates which react with skin structures generating biological damage. Objective: To evaluate the photostability of four sunscreen formulations with Sun Protection Factor (SPF) 30 added by different chemical and physical UV filters. Material and Methods: Each product was exposed to solar radiation from 10 a.m. to 15 p.m. (UV index: 6.0). The areas under the curves (AUC) of the absorbance spectrum of the formulations before and after radiation exposure were used to calculate the ratio between the AUC before and after the solar radiation (AUCI). Results: Only two formulations, which presented the AUCI higher than 0.8, were considered photostable. Despite having the same SPF 30, formulations showed different absorption spectrum in regions of UVA1, UVA2 and UVB and the photostability of the products tested varied considerably. Conclusion: The development of photostable formulations is critical because degradation products of UV filters can act as photo-oxidants. Furthermore, increased exposure to UV radiation due to the reduction of the photoprotective capacity of unstable products increases the risk of burns and skin cancer.

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“…Vilela et al [22] present an analytical process for sunscreen formulations. In this process, the authors used the substances Benzophenone-3, octyl methoxycinnamate and octyl salicylate.…”

Section: Literature Reviewmentioning

confidence: 99%

IoT System for Ultraviolet Ray Index Monitoring

Almeida

Barreto²,

Souto³

et al. 2019

Int J Innov Educ Res

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Este artigo apresenta um sistema de monitoramento de índice ultravioleta usando aplicativos de IoT. O objetivo é auxiliar na prevenção de doenças causadas pela radiação solar ultravioleta por meio de mensagens de aviso com medidas preventivas a cada alteração no nível do índice ultravioleta ao longo do tempo. O monitoramento do índice de UV é de fundamental importância para a prevenção de várias doenças, como câncer de pele, doenças cardiovasculares, falta de cálcio e outras. O sistema apresentou bons resultados no monitoramento do índice UV, apresentando valores medidos dos índices UV de acordo com a radiação solar observada durante os experimentos, classificados de acordo com a Organização Mundial de Saúde (OMS).

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Commercial sunscreen formulations: UVB irradiation stability and effect on UVB irradiation-induced skin oxidative stress and inflammation

Cited by 20 publications

References 50 publications

Protection against UVB deleterious skin effects in a mouse model: effect of a topical emulsion containing Cordia verbenacea extract

Protection against UVB deleterious skin effects in a mouse model: effect of a topical emulsion containing Cordia verbenacea extract

Photostability of commercial sunscreens upon sunlight exposure

IoT System for Ultraviolet Ray Index Monitoring

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