Commercial quartz crystal microbalances – theory and applications

O’Sullivan, Ciara K.; Guilbault, George G.

doi:10.1016/s0956-5663(99)00040-8

Cited by 599 publications

(313 citation statements)

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“…[15][16][17][18][19][20][21][22][23] Among these methods, the quartz crystal microbalance (QCM) biosensor format is being increasingly adopted due to its convenient means of operation coupled with high performance. [24][25][26][27][28][29][30][31][32][33] Measurements can also be performed in real time using native analytes without the need of any labeling procedures.Efficient carbohydrate immobilization techniques to the sensor surface are a prerequisite for the preparation of biosensor systems. In principle, three general strategies can be used to enable carbohydrate presentation at sensor surfaces: direct covalent conjugation of carbohydrate structures to the gold electrode, noncovalent adsorption of carbohydrates on a modified surface, and covalent conjugation of carbohydrate-derivatives to a modified surface.…”

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confidence: 99%

Photoderivatized Polymer Thin Films at Quartz Crystal Microbalance Surfaces: Sensors for Carbohydrate−Protein Interactions

Pei

et al. 2007

Anal. Chem.

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Photoderivatized polymer-coated gold surfaces have been developed following a perfluorophenylazide-based double ligation strategy. Gold-plated quartz crystal microbalance (QCM) crystals were initially covalently functionalized with a monolayer of poly(ethylene glycol) (PEG), using photo-or thermolytic nitrene formation and insertion. The polymer surfaces were subsequently used as substrates for photoinsertion of carbohydrate-derivatized photoprobes, yielding different recognition motifs for selective protein binding. The resulting robust and biocompatible sensor surfaces were applied to a flow-through QCM instrument for monitoring lectin-carbohydrate interactions in real time. The results clearly show the predicted lectin selectivity, demonstrating the applicability of the approach.Selective surface generation and functionalization form the basis for intense research in a number of diverse areas such as chemical sensors, interface engineering, and nanotechnology. A versatile method to covalent derivatization is based on the specific chemistry of arylazides. Upon thermal activation or light irradiation, the azide functionality in these structures becomes converted to a highly reactive nitrene species that readily inserts into CH and NH bonds. 1 Especially perfluorophenylazides (PFPAs), 2 which produce markedly enhanced insertion yields, have thus been used to thermo-and photochemically introduce functional groups in a range of entities, including proteins, nanostructures, and synthetic polymers. [3][4][5][6][7][8][9] The versatility of the PFPA chemistry makes it an attractive choice for surface modification. Surfaces can either be globally modified by the technique, or discrete areas can be addressed by arraying techniques such as photomasking and conventional printing devices. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptThe surface presentation of recognition motifs based on bioactive compounds is central for many applications in bioanalytical and biomaterials science, and carbohydrates and glycomimetic structures are in this context attracting increasing interest. [10][11][12][13][14] Interactions between cellular glycans and proteins have been found to be of special importance in many biological processes, being involved in cell-cell interactions, cell communication, cell proliferation, and cell death. This emerging significance prompts for new means to analytically study these interactions. To date, various methods have been developed to analyze interactions of carbohydrates and proteins, including biosensors, enzyme-linked lectin assays (ELLAs) and cell assays, nuclear magnetic resonance, calorimetric techniques, and, more recently, microarray technologies. [15][16][17][18][19][20][21][22][23] Among these methods, the quartz crystal microbalance (QCM) biosensor format is being increasingly adopted due to its convenient means of operation coupled with high performance. [24][25][26][27][28][29][30][31][32][33] Measurements can also be performed in real tim...

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confidence: 99%

Photoderivatized Polymer Thin Films at Quartz Crystal Microbalance Surfaces: Sensors for Carbohydrate−Protein Interactions

Pei

et al. 2007

Anal. Chem.

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“…[29][30][31]37 As for the measuring techniques, the quartz crystal microbalance (QCM) is a very powerful microsensor to characterize film properties. 38,39 Its main component is a Y-cut piezoelectric quartz crystal plate. An external alternating electric field is applied to the plate through the gold electrodes in order to generate an acoustic wave.…”

Section: Introductionmentioning

confidence: 99%

Theoretical and experimental study of the porous film using quartz crystal microbalance

Zhang

Tian

et al. 2016

Biomicrofluidics

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The self-assembled multilayers have been studied by many researchers to modify the surfaces of artificial implants for increasing biocompatibility. The accurate mechanical properties of the film can only be obtained from the experimental results using appropriate theoretical models. As the film is composed of both solid polymers and fluid, this paper proposes a two-phase model. Based on the volume average method, the momentum equations are derived for both solid and liquid phases. In order to test our model, we built the porous film on the gold chip of the quartz crystal microbalance using the layer-by-layer method. The buildup process is based on the electrostatic interactions between anionic sodium hyaluronate and cationic chitosan by imitating the endothelial surface layer. By fitting our model to the experimental changes of the resonant frequency and dissipation factor, we get reasonable values of the film thickness, the porosity, the shear modulus of the solid phase, and the permeability. Compared with the existing models, the newly introduced permeability is an important property of the porous layer affecting the values of other parameters. Our model can provide more intrinsic properties of the selfassembled polymeric network and explain its interaction with the permeating fluid. Published by AIP Publishing. [http://dx

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“…It has been applied in many areas such as analysis of glucose [8], 8-hydroxy-2-deoxyguanosine [9], lysozyme [10], etc. QCM utilizes the piezoelectric properties of quartz crystals to measure changes in the attached surface mass [11] and usually based on a sensor that can be developed by immobilizing a novel material selective to the template. This selective material that has had much attention is Molecular Imprinted Polymer (MIP).…”

Section: Introductionmentioning

confidence: 99%

“…Then the template is removed after polymerization resulting in the polymer with cavity that has the ability to recognize the template with a high degree of selectivity. To produce MIP of capsaicin, we should apply capsaicin in a system of precomplexation between capsaicin, monomer, crosslinker and solvent, then adding by radical donor agent to initiate polymerization [11]. However, in the aliphatic chain of capsaicin structure (Fig.…”

Section: Introductionmentioning

confidence: 99%

Computer Aided Design of Molecular Imprinted Polymer for Selective Recognition of Capsaicin

Tahir¹,

Wijaya²,

Islam³

et al. 2014

Indones. J. Chem.

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Commercial quartz crystal microbalances – theory and applications

Cited by 599 publications

References 50 publications

Photoderivatized Polymer Thin Films at Quartz Crystal Microbalance Surfaces: Sensors for Carbohydrate−Protein Interactions

Photoderivatized Polymer Thin Films at Quartz Crystal Microbalance Surfaces: Sensors for Carbohydrate−Protein Interactions

Theoretical and experimental study of the porous film using quartz crystal microbalance

Computer Aided Design of Molecular Imprinted Polymer for Selective Recognition of Capsaicin

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